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Jim H's avatar

There is a new twist to the story in the case of those >/= 2X transfected with mRNA.. and that is IgG class switching toward "non-inflammatory" IgG4 antibodies. This is discussed in a new paper out of

Germany that I feel has gotten too little attention by those oriented toward immunology;

https://www.medrxiv.org/content/10.1101/2022.07.05.22277189v1.full.pdf

IgG4 antibodies no longer fight the infection - rather they are a sign that the immune system is tapping out due to overstimulation by an antigen. "Vaccines" are not supposed to do this. The mRNA is clearly hanging around way too long..................

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Modern Discontent's avatar

I was a little concerned when you actually prefaced this post with a "nitty & gritty" remark. I thought we were going to be taken through an entire year of medical school!

I ended up looking up Frances' OAS argument, which appeared in early 1960s (possibly 1960 itself? Although your post of 1953 likely aligns with his initial research timeline). Much of the B-cell research appear to have happened a few years after, with many research coming about during the late 1960s to the 1990s (and onward, really) if the timeline from this article is to be believed.

https://www.nature.com/articles/nri3801

And so that would really line up with the notion that antibodies and OAS were decided before much was known about B and T cells as we do today, and why there are many issues with what we are having right now.

I wonder if much of the talk of OAS has overridden people's conceptions about the adaptive immunity. It is, in essence, a requirement that the adaptive immune system rely on recall in order to tackle a pathogen that shares some similarities to prior ones. So now we have prior immunity recalling a response, and it's assumed to be immediately bad. I even remember reading a part of one of the first mouse studies on OAS where the researchers even commented that the recall would have been a good thing.

I also guess this is all a consequence of everyone just focusing on antibodies and nothing else. The whole immune system is complex and can't be boiled down to the antibodies sticking once, and if they continue to stick again.

I look forward to the Frances portion and see what you write about that!

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