Discussion about this post

User's avatar
Igor Chudov's avatar

Fantastic post! Thank you for directing your attention and competence to this. I believe that we are just getting started really looking at paxlovid.

If I recall correctly, paxlovid was tested on unvaccinated people. If vaccinated people are disproportionally getting viral resurgence, this could be due to the following:

- The 5 day PAUSE button that is called Paxlovid, leads to mostly satisfactory results in UNvaccinated people, whose immune system can mount vigorous response during those 5 days, leading to only 20% viral resurgence

- If vaccinated people, due to immune system damage/tolerance to the spike antigen, are unable to create durable immune response during the same 5 day pause, it could explain resurgence in them.

In addition, it may be that Omicron, despite appearing mild, takes more time to clear and a five day PAUSE is not enough. As you or maybe Modern Discontent alluded to, it may be that the protease inhibitor needs to be given for longer (but hopefully not forever as you mentioned)

In addition, it may be that paxlovid trial was rigged, and resurgences were somehow masked by trial protocol.

Expand full comment
Igor Chudov's avatar
29 more comments...

No posts