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Jim H's avatar

Continuing my rant... if you have got your worry window exposition out of your system Brian.. I wish you could refocus your copius neurons on questions of immunology. What questions? Maybe you saw this piece; https://www.eugyppius.com/p/the-history-of-failed-hiv-vaccine

Title: The history of failed HIV vaccine trials confirms that overvaccination causes class-switching towards non-inflammatory IgG4 antibodies, reducing the effectiveness of the immune response

My sense is that there is something we are missing when it comes to the conditions that invoke IgG4. The Eugyppius post shows that we should have known, in some sense, that injecting epitopes isolated away from the viral whole was somehow a bad idea... and these (HIV gp120-related) proteins weren't even self-replicating.

Since the substack post is paywalled, the paper of interest is here;

https://www.researchgate.net/publication/260950633_Polyfunctional_Fc-Effector_Profiles_Mediated_by_IgG_Subclass_Selection_Distinguish_RV144_and_VAX003_Vaccines

These folks dance around the question, and basically admit we don't know why our immune systems treat "allergy" antigens differently (eventually invoking IgG4) vs. viral antigens.

"The uncharacteristic induction of high levels of IgG4 in the alum based VAX003 regimen may be related to the repeated administration of seven large doses of vaccine antigens in the absence of sufficiently potent adjuvant signals that may have driven excessive B cell receptor triggering. Allergy studies have similarly observed that continuous exposure to high doses of antigen can result in suppressed inflammatory responses through elevated levels of antigen-specific IgG4 (28). However, little is known about the mechanism by which vaccines tune Ab subclass selection."

Little is known indeed.

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Kirsten's avatar

I never heard of the worry window. I always did think it was strange that they didn't count people as vaccinated until after 2 weeks. Looking at the UK waves, respiratory infections are seasonal. I think that's why they released the vaccine in November and December, because respiratory infections were likely to go down in the coming months.

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