Thank you! Hence the giant table in my OAS lit review https://unglossed.substack.com/p/oas-review-timeline-2 - when evaluating the function, or not, of a "learning machine," it matters that the test conditions are apples to apples. Very few of the studies behind imprinting / OAS have bothered.
If the triple-shot group was infected on average one month after their third shot, this creates a cohort of people *for whom the booster failed to prevent Omicron infection at the peak of antibody levels.*
That could be due to individual-level variation in immune responses and antibody epitopes, but it would not be surprising if the folks who were able to be infected one month after injection are, on average, producing a less optimal immune response to spike protein and thereby more vulnerable to reinfection.
That's a good one. The exclusion of pre-December-19 positives might be a counter-argument. However, just like with the false positives it only requires a tiny minority to skew the whole "group's" reinfection rate!
Nice breakdown of that study, thank you. Jeez, every single study needs to be gone through with a fine tooth comb to make sure it's valid.
Thank you! Hence the giant table in my OAS lit review https://unglossed.substack.com/p/oas-review-timeline-2 - when evaluating the function, or not, of a "learning machine," it matters that the test conditions are apples to apples. Very few of the studies behind imprinting / OAS have bothered.
I got some mainstream media immune imprinting for you.
Miami Herald
COVID booster may lower protection against omicron reinfection, study finds. Here’s why
https://www.yahoo.com/news/covid-booster-may-lower-protection-161839527.html
"“If you got infected with Omicron at any time, a third vaccine dose actually doubles your risk of reinfection compared to 2 doses only,” "
Ahh! Doubles! Ahhh! We're doomed!
A possible fourth bullet point:
If the triple-shot group was infected on average one month after their third shot, this creates a cohort of people *for whom the booster failed to prevent Omicron infection at the peak of antibody levels.*
That could be due to individual-level variation in immune responses and antibody epitopes, but it would not be surprising if the folks who were able to be infected one month after injection are, on average, producing a less optimal immune response to spike protein and thereby more vulnerable to reinfection.
That's a good one. The exclusion of pre-December-19 positives might be a counter-argument. However, just like with the false positives it only requires a tiny minority to skew the whole "group's" reinfection rate!