They should really make a vaccine against crushed fingers! I accidentally smashed mine in a door last year and it took months to go away (the bruise under the nail). Yeah and a couple months ago I dropped my phone on my toe and now there's a bruise under the nail there. The nail has to grow the entire length for it to disappear. Why haven't they invented a vaccine for this?
Comparing injected materials, ie claimed 'vaccines', makes no scientific sense to me. In thre header reference to an 'Adenovirus' vaccine invalidates the whole. It is like comparing completely different fuels with different formulation protocols expecting a meaningful result. Plus assuming that antibody counts or types has ANY true value in determining health outcomes is a scientifically proven methodology - it isn't as several measles outbreaks, in three distinct regions / times clearly showed antibodies did not predict illness outcomes.
You are literally bleeding in order to give us this information. Thanks for chiming in about this study - great information between you, modern discontent and igor. Wishing you a speedy healing.
Sorry about the pinky Brian, I hope it heals promptly. The latest igg4 article has a lot of stuff to unpack, so should give us all plenty of material to talk about, discuss, agree, and disagree. Get well soon.
Good luck with the healing! That sounds rough (is it wrong to say ruff?).
I'm about to release my post on the study, and I'm glad you noted the scaling since it can be easy to notice the curves alone and not consider that they aren't exactly measuring the same levels.
In my article I make a note about the IgG2 and the IgA since that seems like something that should be looked into.
But anyways, take care and hopefully it gets better!
Thank you. I'd feel better if I could slash the tires of the two idiots in the airbnb house whose dogs attacked me. Maybe some big stones through the windshield. The problem is that the stupid gate doesn't hold the stupid dogs :(
It sounds like it's a common occurrence, which is a serious issue. So they're apparently staying for a select time and have a dog? That sounds like a recipe for trouble.
The third dog is a known local menace but (in those moments when he has "the look" again) backs up when you face him. But in my mind he was roped up, so I was totally off guard. The other two, I don't know what their problem is. Attacking from a house that isn't even theirs. Crazy.
Vinay Prasad, taking the piss (being sarcastic), looks like his piss take is to become NHS policy.
“This week I saw a 20 year old man in clinic. He had normal BP and a healthy BMI. His LDL was 85. He runs 30 miles a week, eats well, and lifts weights. He had 3 covid shots, as mandated by his university, and, despite that, he still contracted and recovered from COVID (presumably Omicron) over the summer. What did I do?
I see it as more of laying the foundation for a mass testing programme . After all we have all these brand new medical testing facilities that have been all but idle since the Covid testing stopped. 25million is roughly 40% of UK's population. Cohort tested between 25 and 84. It is almost like an admission of guilt.
Off hand, I'm not sure which source that refers to. But post-early-rollout product may have been less pure than what these HCW early adopters received. Maybe more likely, it could all be about distribution, Moderna might be much more prone to staying local and that would certainly make a huge difference. As far as I know there isn't biodistribution data for Moderna, just BNT162b
Very interesting - the counter-evidence for Moderna being "less deadly" is in myocarditis studies, such as Pantone et al. where it was far worse than BNT162b2 https://unglossed.substack.com/p/reversal so actually maybe it doesn't stay more local at all. The disparity in deaths might be due to weird user and reporting biases.
Prior exposure in context of infection = less tolerance.
Remaining to be determined:
1. Do spike IgG4 levels correlate with frequency, duration, or severity of infection?
2. Does infection after vaccination boost or reduce tolerance? (A priori I would expect infection to reduce tolerance, but Irrgang et al. showed a boost and that would potentially be bad news.)
3. Does the fact that these injections are spike-only render this less of an issue than tolerance to the entire virus? Are people with high spike IgG4 able to mount non-tolerant responses to N protein following infection?
re 3, presumably the distributed nature of immune response means no problem. If immune system thinks spike = self, thhat doesn't change much since N is already being encountered around other elements of self (but with DAMPS etc)
Jan 14, 2023·edited Jan 14, 2023Liked by Brian Mowrey
is clearing out the virus using the N signature expected to be as efficient as directly targeting the "immunodominant epitope" or whatever the heck the virologists call the RBD?
I heard somewhere that it takes a couple of weeks for the body to learn how to create well-targeted antibodies to a new antigen. Does this imply that the primary mechanism for clearance of infection, using N as a driver, would be via detecting N producing cells as non-self and destroying them? is that the same mechanism as is used for any new covid infection?
So, IgG4 will still work for "neutralizing" the virus. It sticks to the receptor binding domain, that spike protein is out of commission. So maybe that means, for example, you don't have to worry about an "explosion" of virus in the blood getting into a lot of organs at once.
The problem is how the immune system reacts when it sees viral proteins presented by infected cells. Basically cells have a "currently baking this" reporting system, even though viruses reduce this as much as they can. IgG4 sticks to spike and says "don't react to the protein this cell is making. It also interferes with complement where you need a collection of IgG1s and then cell-destroying proteins auto-destruct the cell. Potentially both these processes can be rescued by N protein antibodies because you only need to destroy the cell showing the virus proteins once. As long as the N antibodies don't also convert to IgG4 for some reason.
Of course, someone has to get infected first before they have N/other antibodies. So for the first infection the IgG4 spike antibodies will be blunting cellular immunity. And so maybe you keep having infected cells, you can never put out all the little brushfires.
Right, any start-point after 40 days is possible. Just know that when they are checked sometime after 100, it has already started
If duration of spike is causing tolerance then 1-dose tolerance is totally possible. Spike is presumably staying around much longer than the dosing interval. But 2 wasn't a total lock for BNT162b2 so you probably need a certain load of RNA, which might require 2 doses.
If something besides duration is causing it, the once again that implicitly means 1-dose tolerance is totally possible
They should really make a vaccine against crushed fingers! I accidentally smashed mine in a door last year and it took months to go away (the bruise under the nail). Yeah and a couple months ago I dropped my phone on my toe and now there's a bruise under the nail there. The nail has to grow the entire length for it to disappear. Why haven't they invented a vaccine for this?
Big Nailpolish would never let it get to market
I'm more impressed by the lack of "premium" adjectives to describe those dogs. 😉
Seriously, I'm sorry to hear about your injury. I hope it's better soon - you should rest in the meantime!
Comparing injected materials, ie claimed 'vaccines', makes no scientific sense to me. In thre header reference to an 'Adenovirus' vaccine invalidates the whole. It is like comparing completely different fuels with different formulation protocols expecting a meaningful result. Plus assuming that antibody counts or types has ANY true value in determining health outcomes is a scientifically proven methodology - it isn't as several measles outbreaks, in three distinct regions / times clearly showed antibodies did not predict illness outcomes.
I am personally still glad my unvaccinated immune system won't think the spike protein is pollen
Ouch!
I'm sorry to hear, Brian.
Maybe off-topic. What would be your take on an MRNA-based rabies vaccine? I am asking for a friend.
What I needed was a vaccine against steel discs
Poor finger. I hope you got an XRay?
Nah. All I'm really worried about is infection. It can heal however it wants. Plenty of other crooked bones already.
You are literally bleeding in order to give us this information. Thanks for chiming in about this study - great information between you, modern discontent and igor. Wishing you a speedy healing.
Thanks! Apparently not "bleeding" but "sanguineously draining." Plus side, helps counteract the swelling.
Sorry about the pinky Brian, I hope it heals promptly. The latest igg4 article has a lot of stuff to unpack, so should give us all plenty of material to talk about, discuss, agree, and disagree. Get well soon.
Thank you! Promptly, I don't know about, haha. It looks like it owed the Pinky Mafia a few tens of thousands of dollars.
Good luck with the healing! That sounds rough (is it wrong to say ruff?).
I'm about to release my post on the study, and I'm glad you noted the scaling since it can be easy to notice the curves alone and not consider that they aren't exactly measuring the same levels.
In my article I make a note about the IgG2 and the IgA since that seems like something that should be looked into.
But anyways, take care and hopefully it gets better!
Thank you. I'd feel better if I could slash the tires of the two idiots in the airbnb house whose dogs attacked me. Maybe some big stones through the windshield. The problem is that the stupid gate doesn't hold the stupid dogs :(
It sounds like it's a common occurrence, which is a serious issue. So they're apparently staying for a select time and have a dog? That sounds like a recipe for trouble.
The third dog is a known local menace but (in those moments when he has "the look" again) backs up when you face him. But in my mind he was roped up, so I was totally off guard. The other two, I don't know what their problem is. Attacking from a house that isn't even theirs. Crazy.
Hopefully it's not to serious, but wow highly defensive dogs it seems which is something that the owners should be aware of.
OH NOOO!!! Feel better!! Wishing you a speedy healing and thank you for sharing while injured!
Thank you!
Topic of the day in UK : https://www.theguardian.com/society/2023/jan/12/new-statins-guidelines-nice-nhs-england a lot new prescriptions for statins.
Vinay Prasad, taking the piss (being sarcastic), looks like his piss take is to become NHS policy.
“This week I saw a 20 year old man in clinic. He had normal BP and a healthy BMI. His LDL was 85. He runs 30 miles a week, eats well, and lifts weights. He had 3 covid shots, as mandated by his university, and, despite that, he still contracted and recovered from COVID (presumably Omicron) over the summer. What did I do?
I started Atorva 80mg qday.”
https://sensiblemed.substack.com/p/no-a-healthy-20-year-old-man-who?utm_source=%2Finbox&utm_medium=reader2
Interesting - I am not sure if those would be any help in the type of cardiovascular "disease" that results from spike transfections
I see it as more of laying the foundation for a mass testing programme . After all we have all these brand new medical testing facilities that have been all but idle since the Covid testing stopped. 25million is roughly 40% of UK's population. Cohort tested between 25 and 84. It is almost like an admission of guilt.
"Pfizer Pfizer Über Alles" has a better ring to it though...
Why do you think Pfizer kills more people than Moderna per million jabs in data from Australia, France, Japan, Germany, UK?
Off hand, I'm not sure which source that refers to. But post-early-rollout product may have been less pure than what these HCW early adopters received. Maybe more likely, it could all be about distribution, Moderna might be much more prone to staying local and that would certainly make a huge difference. As far as I know there isn't biodistribution data for Moderna, just BNT162b
I keep a running review as new data comes to hand.
https://www.researchgate.net/post/Relative_Lethality_of_COVID-19_vaccines-who_is_measuring_the_casualties
Very interesting - the counter-evidence for Moderna being "less deadly" is in myocarditis studies, such as Pantone et al. where it was far worse than BNT162b2 https://unglossed.substack.com/p/reversal so actually maybe it doesn't stay more local at all. The disparity in deaths might be due to weird user and reporting biases.
Yes that is why I look at as many countries as I can find. Reporting is mandatory in some countries.
Thanks for writing despite your injury!
So...the system is behaving as expected.
More exposure via vaccination = more tolerance.
Prior exposure in context of infection = less tolerance.
Remaining to be determined:
1. Do spike IgG4 levels correlate with frequency, duration, or severity of infection?
2. Does infection after vaccination boost or reduce tolerance? (A priori I would expect infection to reduce tolerance, but Irrgang et al. showed a boost and that would potentially be bad news.)
3. Does the fact that these injections are spike-only render this less of an issue than tolerance to the entire virus? Are people with high spike IgG4 able to mount non-tolerant responses to N protein following infection?
re 3, presumably the distributed nature of immune response means no problem. If immune system thinks spike = self, thhat doesn't change much since N is already being encountered around other elements of self (but with DAMPS etc)
is clearing out the virus using the N signature expected to be as efficient as directly targeting the "immunodominant epitope" or whatever the heck the virologists call the RBD?
I heard somewhere that it takes a couple of weeks for the body to learn how to create well-targeted antibodies to a new antigen. Does this imply that the primary mechanism for clearance of infection, using N as a driver, would be via detecting N producing cells as non-self and destroying them? is that the same mechanism as is used for any new covid infection?
So, IgG4 will still work for "neutralizing" the virus. It sticks to the receptor binding domain, that spike protein is out of commission. So maybe that means, for example, you don't have to worry about an "explosion" of virus in the blood getting into a lot of organs at once.
The problem is how the immune system reacts when it sees viral proteins presented by infected cells. Basically cells have a "currently baking this" reporting system, even though viruses reduce this as much as they can. IgG4 sticks to spike and says "don't react to the protein this cell is making. It also interferes with complement where you need a collection of IgG1s and then cell-destroying proteins auto-destruct the cell. Potentially both these processes can be rescued by N protein antibodies because you only need to destroy the cell showing the virus proteins once. As long as the N antibodies don't also convert to IgG4 for some reason.
Of course, someone has to get infected first before they have N/other antibodies. So for the first infection the IgG4 spike antibodies will be blunting cellular immunity. And so maybe you keep having infected cells, you can never put out all the little brushfires.
Sampling seems somewhat irregular so difficult to say when elevated IgG4 actually starts?
K: Biontech + Biontech ~ 140 days after 1st dose
K: Moderna + Moderna ~ 130 days after 1st dose
L: Astra + Moderna ~ 140 days after 1st mRNA dose
L: Astra + Biontech ~ 100 days after 1st mRNA
M: Pre-infected + Biontech ~ 140 days after 1st mRNA
I had hoped spike in IgG4 was triggered by booster but you and others have pointed to papers showing elevated IgG4 levels already before booster.
What if 1st mRNA dose is causal but takes over 4 months to manifest? What might be mechanism for body to trigger switch to IgG4?
How long is spike produced & how long does it remain? Might body be trying to fight/clear spike for ~4 months before conceding then switches to IgG4?
Or is this just coincidental sampling dates from new study?
Right, any start-point after 40 days is possible. Just know that when they are checked sometime after 100, it has already started
If duration of spike is causing tolerance then 1-dose tolerance is totally possible. Spike is presumably staying around much longer than the dosing interval. But 2 wasn't a total lock for BNT162b2 so you probably need a certain load of RNA, which might require 2 doses.
If something besides duration is causing it, the once again that implicitly means 1-dose tolerance is totally possible