Musings on a "sibling lineage"
Paul Offit has also argued that there's a limit on where the spike protein mutations can go. He also argued that the virus can get cornered with nowhere to go by repeated vaccination.
But aren't T-cells or any other antibodies essentially ineffective in the upper respiratory tract. We haven't gotten rid of other coronaviruses, so why would
this one be different?
It seems there's still a lot of "research" going on with passing the virus through
mice. What could go wrong? In the past, this sort of risky research was mainly confined to military lab, but now it seems that every university is doing this.
I am always interested to see differences in the Furin Cleavage Site sequence in mutants, er, variants. Word on the street is that the Spike FCS of the Omicron(s) is still present and Furin-sensitive, though altered from the OG and obviously unrelated to Delta. Anybody got a line on that? Because if FCS suddenly "went away" one day through a natural "live attenuated virus" then the disease badness evaporates too. I am frankly surprised that friendly countries with a lot of technological savvy and a lot to gain haven't already tried this. (Looking right at you Israel.)
You are lending alot of credence to H2BH's viral swarms initiative. Yes the virus exists in many different genetic forms when it is replicating inside you. Who is to say that BA2 is a "new" infection - or just a part of the original infection.
I think UK is the one to watch next. It is rising rapidly here but might just fizzle out like you say.
Delighted that you're back from ''Foggyland'' - even if seeing more clearly is not always an advantage ;-)
Speaking of ''clearly'':
An essential problem of human considerations of bio-logical interweavings in the context of evolution, is the corset-like linearization of said interweavings. A simplification is carried out in order to get, from our point of view, a clear picture that can be traced in its development by means of a timeline. However, it is completely overlooked that by this simplification of the ''clear'' picture, the essential information is completely lost. What remains are more and more snapshots, which do not show any useful correspondences with evolution. Thus the fog gets thicker. Maybe you are even deeper in ''Foggyland'' than before getting foggy in the brain.
I like your Elvis comparison. Not only since Corona it is revealed that more and more people are also born as originals, but by ''scientific'' simplifications die more and more often as copies. One simplification to rule them all?
I can only imagine you are still writing because you are surviving your current infection, and it is less virulent than the infamous man flu.
I still feel like I'm missing some information on Omicron. Here's what I'm puzzling over:
1. Son & girlfriend had what sure looked like it must have been the original Covid in Nov. 2019.
2. They have remained unvaxed and have not gotten sick again, until....
3. Got sick about 3 weeks ago. Him first, her about 6 hours later. He never tested, she tested positive. Was this Omicron 1 or 2?
4. I've read of Omicron hitting a second time a couple of weeks after the first time...BUT...is this a situation with vaccinated people? Or both vaccinated AND unvaccinated?
5. IF they had Covid in Nov. 2019 (can never know since there were no tests then), and IF they had Omicron a few weeks ago, it looks like natural immunity didn't help protect against Omicron. Or is that to be expected anyway since the two viruses have a different spike protein?
I'd like to see a chart comparing "cases" with tests. I expect they'll correlate pretty well. We've been mass producing tests, and hypochondriacs are lining up in the snow to get tested. Not surprising that would also increase asymptomatic cases. Every time I hear of someone with infection, they're uncomfortable til they get zpack or ivermectin, then they're fine. Cases are a scam.
Around Thanksgiving, all three members of my household had mild symptoms and tested positive on antigen tests multiple times. Then, just before the New Year, we succumb to a second round of positive antigen tests, but rougher symptoms. I believe my child was the one who brought the first round to our family from school and that the low viral load kept the adults' symptoms very mild. The second bout, a high viral load after one adult was in a car and recording studio with a double vaxxed who had just returned from holiday travel to Mexico. Each of us was hit with fever and body aches to start. I had the worst symptoms to follow- extreme fatigue, heart palpitations, altered taste and smell and cold sweats. Surely, after being hit twice with different strains (presumably, no sequencing done) - we are done, right? Please say yes. I am done being fucked with by humans playing god.
I'll just say thank god the other 4 human coronaviruses have the decency and respect to never ever mutate or produce genetic variations that one could detect if they plowed billions of dollars into worldwide surveillance testing!