8 Comments
Jan 25Liked by Brian Mowrey

Great summary, looking forward to Explaining polio, pt 3!

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Jan 25Liked by Brian Mowrey

Getting to the root of this polio problem is very important I believe and I’m looking forward to your upcoming posts. However I’m getting rather lost in the details and couldn’t explain your work to someone else! When finished would you consider producing a video summary of everything that could be shown to others, or explaining it all to someone on a podcast? DocMalik is a very friendly orthopaedic surgeon, now out of work due to speaking against the covid narratives, who has all sorts of interesting guests on his podcast and he allows them to speak freely.

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Jan 25Liked by Brian Mowrey

The probability of developing paralytic disease is oddly small that it seems there should be an explanation for vast communities with existing antibodies that did not suffer disease outbreaks. The provocation poliomyelitis theory is still interesting. I wonder if there is any merit to the possibility that disease development could be linked to toxins/viruses/etc. that are chronically demyelinating and/or inflammatory but not necessarily to an extent of presenting other acutely recognizable degeneration. It seems key that polio can pass the BBB and attack the anterior horn. How does it get there? The body first needs a red carpet to be able to roll one out.

There are certainly other mimics (AFP, Guillain-Barré, etc) where demyelination is a paramount mechanism to symptoms, as well as other enteroviruses that have similar presentation. Guillain-Barré handshakes with pneumoniae; perhaps there is a similar synergy/comorbidity for polio. There have been some polio comorbidity studies, but all seem rather shotgun spray (ie laundry list of generally poor health markers), or they focus on sequelae.

Your work is always thought-provoking and interesting. Thank you.

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