Thank you so much for this post! I've been trying to wrap my head around OAS, and I've written about it previously and why I felt as if the mentions of OAS were being misattributed, including the UK data. I think your perspective is far better in your analysis, as I just posited that it may have been due to viral removal before antigen p…
Thank you so much for this post! I've been trying to wrap my head around OAS, and I've written about it previously and why I felt as if the mentions of OAS were being misattributed, including the UK data. I think your perspective is far better in your analysis, as I just posited that it may have been due to viral removal before antigen presentation since the N protein is sequestered within the virus, although that is definitely a parochial perspective.
I think this really just highlights that there's so much nuance and complexity to really discuss here and that we should be hesitant when we are adamant about a position. I'm really bad with virology and certain aspects of molecular biology. I find I much prefer to examine medicinal chemistry and pharmacology, so a lot of this tends to really go over my head and takes plenty of time to examine.
As much as I consider everything that goes on ridiculous, I do think we need to remain rational and not counter the craziness going on with our own misreadings and misinterpretations of the data, so thanks for your analysis!
Right, it's certainly plausible that early breakthrough infections are essentially abortive when it comes to whatever stage of infection would normally be followed by N seroconversion. And October, when the text appeared in the UKHSA document, was still very much "early breakthrough infection study season." But if the reader wasn't following MSM science journalism at the time, they wouldn't know that, and the writer could just say "Oh look it says 'recent', that means recent."
And studies of "post-Barnstable-era" breakthrough antibody kinetics *still* haven't really arrived. But post-Barnstable is when 99% of breakthrough infections occurred and is thus the only reality relevant for most of the injected.
Meanwhile, N-antibodies are shooting up among UK donors for the last months while the UKHSA comment saying N antibodies aren't rising is still scare-quoted everywhere.
Thank you so much for this post! I've been trying to wrap my head around OAS, and I've written about it previously and why I felt as if the mentions of OAS were being misattributed, including the UK data. I think your perspective is far better in your analysis, as I just posited that it may have been due to viral removal before antigen presentation since the N protein is sequestered within the virus, although that is definitely a parochial perspective.
I think this really just highlights that there's so much nuance and complexity to really discuss here and that we should be hesitant when we are adamant about a position. I'm really bad with virology and certain aspects of molecular biology. I find I much prefer to examine medicinal chemistry and pharmacology, so a lot of this tends to really go over my head and takes plenty of time to examine.
As much as I consider everything that goes on ridiculous, I do think we need to remain rational and not counter the craziness going on with our own misreadings and misinterpretations of the data, so thanks for your analysis!
Right, it's certainly plausible that early breakthrough infections are essentially abortive when it comes to whatever stage of infection would normally be followed by N seroconversion. And October, when the text appeared in the UKHSA document, was still very much "early breakthrough infection study season." But if the reader wasn't following MSM science journalism at the time, they wouldn't know that, and the writer could just say "Oh look it says 'recent', that means recent."
And studies of "post-Barnstable-era" breakthrough antibody kinetics *still* haven't really arrived. But post-Barnstable is when 99% of breakthrough infections occurred and is thus the only reality relevant for most of the injected.
Meanwhile, N-antibodies are shooting up among UK donors for the last months while the UKHSA comment saying N antibodies aren't rising is still scare-quoted everywhere.