Now that almost everybody has been either exposed to many different variants or vaccinated, everybody has some imprinting (either natural or via vaccine).
Two questions:
1. If we were able to predict next variant A' (which we obviously can't) and vaccinate against that variant before it hit (now we can produce antibodies A' *before* we ge…
Now that almost everybody has been either exposed to many different variants or vaccinated, everybody has some imprinting (either natural or via vaccine).
Two questions:
1. If we were able to predict next variant A' (which we obviously can't) and vaccinate against that variant before it hit (now we can produce antibodies A' *before* we get infected) , wouldn't OAS mean that previously vaccinated would be more susceptible?
2. But the same thing also applies for people that were naturally infected.
Imprinting happens there as well. Right? This is what happens with flu. Immune system is imprinted with the first flu you encounter.
Let’s assume natural immunity against A is superior to artificial immunity against A’ because mucosal /cellular immune programming + related antigen recognition.
Are people juiced up with A’ antibodies better off than people juiced up with A antibodies (who now can’t have their artificial programming rewritten) in challenge with A’? Well, actually, maybe not - maybe a bit of difference leads to an enriched or more robust “immune correction” while still protecting against viremia. The funny thing is that OAS isn’t even sure which answer confirms the “sin” - a Eugyppius can fire off a post saying either result is proof of OAS!
Yes, and the more I look into both OAS and ADE the murkier it is.
And let's face it, because the data is so crappy (either by design or by incompetence) it's hard enough to see through the fog
if you are genuinely trying to uncover the truth. If you are just searching for confirmation of your prior belief or your hypothesis, then it's great because you can show pretty much anything.
It's also interesting that OAS might have occurred with H1N1
And these mRNA (and adenovirus) vaccines were developed and sold with the premise that we know exactly what happens in our body and what those developed antibodies will do.
Now that almost everybody has been either exposed to many different variants or vaccinated, everybody has some imprinting (either natural or via vaccine).
Two questions:
1. If we were able to predict next variant A' (which we obviously can't) and vaccinate against that variant before it hit (now we can produce antibodies A' *before* we get infected) , wouldn't OAS mean that previously vaccinated would be more susceptible?
2. But the same thing also applies for people that were naturally infected.
Imprinting happens there as well. Right? This is what happens with flu. Immune system is imprinted with the first flu you encounter.
Let’s assume natural immunity against A is superior to artificial immunity against A’ because mucosal /cellular immune programming + related antigen recognition.
Are people juiced up with A’ antibodies better off than people juiced up with A antibodies (who now can’t have their artificial programming rewritten) in challenge with A’? Well, actually, maybe not - maybe a bit of difference leads to an enriched or more robust “immune correction” while still protecting against viremia. The funny thing is that OAS isn’t even sure which answer confirms the “sin” - a Eugyppius can fire off a post saying either result is proof of OAS!
Yes, and the more I look into both OAS and ADE the murkier it is.
And let's face it, because the data is so crappy (either by design or by incompetence) it's hard enough to see through the fog
if you are genuinely trying to uncover the truth. If you are just searching for confirmation of your prior belief or your hypothesis, then it's great because you can show pretty much anything.
It's also interesting that OAS might have occurred with H1N1
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3165229/
but it's remarkable that we really don't know much and for sure.
It's also clear that many vaccines are a product of guess as opposed to deep and solid understanding:
https://www.nature.com/articles/nm1216
And these mRNA (and adenovirus) vaccines were developed and sold with the premise that we know exactly what happens in our body and what those developed antibodies will do.