Brief discussion of a simple mechanism (for an anecdotally proposed Covid vaccine harm which, I must say, I haven't seen much evidence of here in SoCal).
"Additionally, Szebeni, J. et al.’s 50-80nm LNPs might all contain partial RNAs"
How big is the mRNA molecule? I thought the LNPs contained many many mRNAs in them , packed something like illustrated in the "LNPs" picture at https://www.precisionnanosystems.com/workflows/payloads/mrna (see the section titled Overcome Challenges in mRNA Delivery)
Most of the prior analysis and resulting models were based on smaller siRNA LNPs. For these products, as Szebeni et al say "the nanoscale structure of these formulations is still poorly understood." So I just work with a model that most have just one molecule. This better accounts for the extreme differences between fresh and not-fresh versions, as molecule-on-molecule interactions start to produce all these "self-assembling" structures. So if you have discrete spheres I think that suggests just one molecule inside. Obviously, I don't really know.
You mean the injected in Southern California aren't turbo aging like the antagonist in the "he chose poorly" scene from Indiana Jones and the Last Crusade? (https://www.youtube.com/watch?v=VA7J0KkanzM) LOL
Seriously though, while your theory is a good one, I'm wondering if the term for the phenomenon is a bit of misnomer and its mechanism (if it does indeed happen) is a quite simple one. While it is true we don't see people suddenly looking 10 years older, the human body can age in ways that cannot be readily observed: namely, organ damage and (ultimately) premature failure.
If indeed spike is cytotoxic and if the mRNA injected have ungodly amounts of spike circulating in them (just came across this recently published study yesterday: https://doi.org/10.1111/apm.13294 ("SARS-CoV-2 spike mRNA vaccine sequences circulate in blood up to 28 days after COVID-19 vaccination")), then spike may be doing damage to organs (albeit unbeknownst to the individual). And, while the body does heal, damaged tissue, organs, etc. (including smashed pinkys LOL), may remain somewhat vulnerable and/or compromised.
In other words, damage to certain organs, caused by spike (if it is indeed doing so), could shorten the lifespan of the injected: their body will age quicker, like that of a drug and alcohol addict whose organs have been bombarded with toxins.
... by a guitar tech I knew, who in turn knew that species called "rock musicians". One of them his buddy. Who also had a big chest in his attic or something. He called that chest "the Ark", and, according to legend as it was passed on to me, also contained miscellaneous white powders that might create scenery somewhat similar to those in the movie clip, at least from the view of the consumer of said powders...
I agree; I didn't want to clog up the post but that is what I would call the other lead subject *edit suspect. I can never see what I'm typing in comments. It's just generic injury, systemic but in a random distribution. Like a decade of rough living.
The circulating mRNA matches the Romania paper from my myocarditis post - https://www.mdpi.com/2227-9059/10/7/1538 - 15 days is just the limit of how far out they looked. I think these are just LNPs that are still floating around, but who knows. With the new paper, which seems difficult to access, it's not clear if it's 10% of everyone within 28 days or more a question of the distribution of timing.
I had the same question/thought regarding said study.
Notwithstanding, there seems to be growing evidence that these jabs can be toxic to the body (which may, as it just occurred to me, explain the IgG class switching phenomenon (the immune system may be trying to protect the body from chronic inflammation)). But to what distribution and/or degree, who knows--its all one big experiment.
Maybe I've posted this thought here before so forgive me if so; it's almost an obsession with me because I like logical thinking. But the message from our CDC was "the spike protein on the virus is bad. So take this shot which will train your cells to make spike protein."
That was the basis for a lot of claims of benefit. I'm not a biologist. But something about that sounded bad. Because in none of the propaganda did anybody say how many cells, for how long, and what would force closure to the spike production. And now it seems the worst you can imagine is happening to large numbers of shot recipients. Like Brian says somewhere here, it's like a bad science fiction novel.
Most of my friends and family, the people I see frequently at church and at large have taken at least one of the mRNA or DNA shots. I'm not seeing anything on their faces that suggests rapid aging. Nor are they going gray fast... Well, except for female friends who ditched the hair dye because..I guess they wanted to look older.
If anything, I look aged from sorting through the hysterical signals from government and media. Three years of this power grab by overpaid cretins.. Now that put wrinkles on my face.
Interesting to me that you have not observed this in SoCal ... Do you notice any difference at all among people in public? ... Any loss of color, vitality, etc.?
No, really not at all. Of course some people look like they have serious issues, but that's always been the case.
It was a big surprise, last summer. Before the stupid masks went away you couldn't tell, and if someone did look healthy, there was no way to tell if they were just the rare exception to the rule because most people were still hiding from the world. But then everyone came back out, looked normal.
Still attached to an unusable, broken pinky - which per web-md is another week away from the earliest point of resumption of movement. But otherwise mostly functional. I can do hand-stands, but obviously can't swim.
LOL clearly handstands are not a necessity when you have a broken pinky. I crushed 3 fingers a couple of years ago trying to fix my car's motorized window...broke one, lost the fingernail on another, sutures on all 3, etc. Have you seen a hand surgeon or just WebMD :-)?
Ok, motorized window vs fingers, that sounds hard core. I wouldn't trade.
No surgeons. I had a certain "friend," way back in 2006, initials "BM," who went to a surgeon for a classic boxer's break for the right hand and was told "let's get that fixed," surgery. Three weeks later, went to the same surgeon for a boxer's break on the left hand. Surgeon sent him home to let it heal on its own. So that's when I learned that hand surgery is just busy-work.
Interesting. Three years ago I broke a toe and maybe a metatarsal or two on my right foot on a friend's staircase. I figured what's a podiatrist going to do for me? So I let it heal on its own.
Ten years ago climbing over (my own) fence I failed to see the deep hole under the snow that I was vaulting into. Pretty sure I broke something, felt like it tore my foot clean off, but figured it would heal on its own. And so it did.
Case in counterpoint my sister in-law has a tendency to roll and sprain her ankles. She goes to doctors for it and winds up in casts and boots.
It seems if you consult a doctor he's going to have to do something for you.
Ouch, the snow one sounds not-fun. But right, doctors will over-treat broken bones I think. I probably would have gone if it was a different finger just to not invite a loss of basic grip.
I did accept / embrace surgery after the bicycle accident shattered my cheekbone. At the same time the sports doctor was good, endorsed letting both clavicles heal ugly instead of pins that can fall out later which would be terrifying to live with. So I'm only 67% a luddite with medicine.
I had a bike accident where a friend cut hard in front of me as we were rolling fast downhill. I got thrown over the handlebars and was years later to need cervical fusion at two levels. My friend said something about the noise my skull made on the pavement, but at the time I was so busy with a skinned forearm I thought, eh!
But a shattered cheekbone! No, we don't do that at home. And broken clavicles? That was some accident.
Brian, this won't win you over because my argument is anecdotal, but I have absolutely observed accelerated rapid decline in health and cognitive function in the seniors among my patients in community pharmacy. I had the opportunity to know many of these patients well enough before COVID to have a strong baseline impression against which to compare the rate of enfeeblement.
The evidence that SARS-CoV-2 dysregulates immunity more than any other infection is paper-thin. A lot of conflation of issues, eg "look it has innate immune disabling genes [as does literally every virus, how else would they ever infect anyone]" + "look at these severe cases where 80 year olds ran out of T Cells." Nope... not a get out of jail free card for the gene therapy injections.
"Additionally, Szebeni, J. et al.’s 50-80nm LNPs might all contain partial RNAs"
How big is the mRNA molecule? I thought the LNPs contained many many mRNAs in them , packed something like illustrated in the "LNPs" picture at https://www.precisionnanosystems.com/workflows/payloads/mrna (see the section titled Overcome Challenges in mRNA Delivery)
Most of the prior analysis and resulting models were based on smaller siRNA LNPs. For these products, as Szebeni et al say "the nanoscale structure of these formulations is still poorly understood." So I just work with a model that most have just one molecule. This better accounts for the extreme differences between fresh and not-fresh versions, as molecule-on-molecule interactions start to produce all these "self-assembling" structures. So if you have discrete spheres I think that suggests just one molecule inside. Obviously, I don't really know.
It's remarkable what they haven't found by not looking. :(
Yes... another element of the whole thing that would look flippant and ridiculous in a science fiction novel.
"Californians are vein..."
Is that a hematopoetic slip or am I missing something/
A typo...
You mean the injected in Southern California aren't turbo aging like the antagonist in the "he chose poorly" scene from Indiana Jones and the Last Crusade? (https://www.youtube.com/watch?v=VA7J0KkanzM) LOL
Seriously though, while your theory is a good one, I'm wondering if the term for the phenomenon is a bit of misnomer and its mechanism (if it does indeed happen) is a quite simple one. While it is true we don't see people suddenly looking 10 years older, the human body can age in ways that cannot be readily observed: namely, organ damage and (ultimately) premature failure.
If indeed spike is cytotoxic and if the mRNA injected have ungodly amounts of spike circulating in them (just came across this recently published study yesterday: https://doi.org/10.1111/apm.13294 ("SARS-CoV-2 spike mRNA vaccine sequences circulate in blood up to 28 days after COVID-19 vaccination")), then spike may be doing damage to organs (albeit unbeknownst to the individual). And, while the body does heal, damaged tissue, organs, etc. (including smashed pinkys LOL), may remain somewhat vulnerable and/or compromised.
In other words, damage to certain organs, caused by spike (if it is indeed doing so), could shorten the lifespan of the injected: their body will age quicker, like that of a drug and alcohol addict whose organs have been bombarded with toxins.
Hah. That reminds me of another scene that has been jokingly (?) likened to reality...
https://www.youtube.com/watch?v=0APF3SO9tqE&t=1m3s
... by a guitar tech I knew, who in turn knew that species called "rock musicians". One of them his buddy. Who also had a big chest in his attic or something. He called that chest "the Ark", and, according to legend as it was passed on to me, also contained miscellaneous white powders that might create scenery somewhat similar to those in the movie clip, at least from the view of the consumer of said powders...
I agree; I didn't want to clog up the post but that is what I would call the other lead subject *edit suspect. I can never see what I'm typing in comments. It's just generic injury, systemic but in a random distribution. Like a decade of rough living.
The circulating mRNA matches the Romania paper from my myocarditis post - https://www.mdpi.com/2227-9059/10/7/1538 - 15 days is just the limit of how far out they looked. I think these are just LNPs that are still floating around, but who knows. With the new paper, which seems difficult to access, it's not clear if it's 10% of everyone within 28 days or more a question of the distribution of timing.
Right.
I had the same question/thought regarding said study.
Notwithstanding, there seems to be growing evidence that these jabs can be toxic to the body (which may, as it just occurred to me, explain the IgG class switching phenomenon (the immune system may be trying to protect the body from chronic inflammation)). But to what distribution and/or degree, who knows--its all one big experiment.
Maybe I've posted this thought here before so forgive me if so; it's almost an obsession with me because I like logical thinking. But the message from our CDC was "the spike protein on the virus is bad. So take this shot which will train your cells to make spike protein."
That was the basis for a lot of claims of benefit. I'm not a biologist. But something about that sounded bad. Because in none of the propaganda did anybody say how many cells, for how long, and what would force closure to the spike production. And now it seems the worst you can imagine is happening to large numbers of shot recipients. Like Brian says somewhere here, it's like a bad science fiction novel.
Most of my friends and family, the people I see frequently at church and at large have taken at least one of the mRNA or DNA shots. I'm not seeing anything on their faces that suggests rapid aging. Nor are they going gray fast... Well, except for female friends who ditched the hair dye because..I guess they wanted to look older.
If anything, I look aged from sorting through the hysterical signals from government and media. Three years of this power grab by overpaid cretins.. Now that put wrinkles on my face.
I look 3 years older than when this whole thing started!
Interesting to me that you have not observed this in SoCal ... Do you notice any difference at all among people in public? ... Any loss of color, vitality, etc.?
No, really not at all. Of course some people look like they have serious issues, but that's always been the case.
It was a big surprise, last summer. Before the stupid masks went away you couldn't tell, and if someone did look healthy, there was no way to tell if they were just the rare exception to the rule because most people were still hiding from the world. But then everyone came back out, looked normal.
How's your hand?
Still attached to an unusable, broken pinky - which per web-md is another week away from the earliest point of resumption of movement. But otherwise mostly functional. I can do hand-stands, but obviously can't swim.
LOL clearly handstands are not a necessity when you have a broken pinky. I crushed 3 fingers a couple of years ago trying to fix my car's motorized window...broke one, lost the fingernail on another, sutures on all 3, etc. Have you seen a hand surgeon or just WebMD :-)?
Ok, motorized window vs fingers, that sounds hard core. I wouldn't trade.
No surgeons. I had a certain "friend," way back in 2006, initials "BM," who went to a surgeon for a classic boxer's break for the right hand and was told "let's get that fixed," surgery. Three weeks later, went to the same surgeon for a boxer's break on the left hand. Surgeon sent him home to let it heal on its own. So that's when I learned that hand surgery is just busy-work.
Interesting. Three years ago I broke a toe and maybe a metatarsal or two on my right foot on a friend's staircase. I figured what's a podiatrist going to do for me? So I let it heal on its own.
Ten years ago climbing over (my own) fence I failed to see the deep hole under the snow that I was vaulting into. Pretty sure I broke something, felt like it tore my foot clean off, but figured it would heal on its own. And so it did.
Case in counterpoint my sister in-law has a tendency to roll and sprain her ankles. She goes to doctors for it and winds up in casts and boots.
It seems if you consult a doctor he's going to have to do something for you.
Ouch, the snow one sounds not-fun. But right, doctors will over-treat broken bones I think. I probably would have gone if it was a different finger just to not invite a loss of basic grip.
I did accept / embrace surgery after the bicycle accident shattered my cheekbone. At the same time the sports doctor was good, endorsed letting both clavicles heal ugly instead of pins that can fall out later which would be terrifying to live with. So I'm only 67% a luddite with medicine.
I had a bike accident where a friend cut hard in front of me as we were rolling fast downhill. I got thrown over the handlebars and was years later to need cervical fusion at two levels. My friend said something about the noise my skull made on the pavement, but at the time I was so busy with a skinned forearm I thought, eh!
But a shattered cheekbone! No, we don't do that at home. And broken clavicles? That was some accident.
Brian, this won't win you over because my argument is anecdotal, but I have absolutely observed accelerated rapid decline in health and cognitive function in the seniors among my patients in community pharmacy. I had the opportunity to know many of these patients well enough before COVID to have a strong baseline impression against which to compare the rate of enfeeblement.
Maybe it's the masks.
Decline from the injections or from contracting Covid?
Different kinds of decline for each.
Pfizer reports 90 different Endocrine Disorders in tens of thousands of its jab victims to 15 April 2022.
Includes 11 different Pituitary disorders. 20 different Growth disorders.
"vein" and "vain," while pronounced the same are spelled differently :-)
Here is a twitter thread where some Internet Rando is trying to provoke hysteria over all the "really bad things(tm)" Covid can do to you:
https://twitter.com/RaffyFlynnArt/status/1602033509568225280
The evidence that SARS-CoV-2 dysregulates immunity more than any other infection is paper-thin. A lot of conflation of issues, eg "look it has innate immune disabling genes [as does literally every virus, how else would they ever infect anyone]" + "look at these severe cases where 80 year olds ran out of T Cells." Nope... not a get out of jail free card for the gene therapy injections.
Agh! I forgot my Clash song title guide to spelling homonyms!