The methodology in this paper -- for reconstructing phylogenetic tree by an ordering method that does not rely on a "clock" (eg as Trever Bedford does) -- might be interesting applied to the Omicron data. The paper gives what seems likely to be a much more accurate picture of the original root (which they find preceded original Wuhan strain) for the 2020 tree. Would like to see what the method finds for Omicron lineages. https://academic.oup.com/mbe/article/38/8/3046/6257226
Substack is where the conversation went that used to take place in the scientific literature, I guess. It's reassuring to see such thinking and explaining going on, as it includes self-doubt and allows for future correction based on more data. When contrasted with the top-down edicts of recent years, it makes one realize how amazingly corrupt it's become, as predicted by President Eisenhower in his Farewell Address.
This is all very interesting Brian. Like I stated in a comment from one of my posts, I wished I kept up with looking into Omicron. As soon as it appeared that things would end soon I stopped looking. Well, that was probably the wrong position to take!
I've been trying to relate Omicron and the current issue with the whole "immune invasion" or the more virulent nature of Ba.4/Ba.5. I think one of the only ways is to conceptualize Wuhan and Omicron lineages (being used loosely here) as distinct and to essentially decouple them from one another in order to address what's going on. That creates all sorts of problems, but I suppose that's what makes it a working model.
Anyways, great work! I think I should look deeper into the orf mutations- and mostly things outside of the spike as well.
Incredible posts like this is why I subscribe to your substack. Well done!
Are you familiar with the viral quasispecies theory? According to this theory, an infection is really an infection with many related viruses, which coexist in varying proportions. So if Ba.1 is predominant in the Qs, it mostly shows in sequencing and you may miss the lower prevalent ba.2 and ba.4 and ba.5.
But once immune landscape changes, other Qs members may gain higher prominence.
So, it is possible that they were all released as one quasispecies?
If some group is deliberately releasing variants, that might explain the extreme COVID policies. The lab leak theory is not new, but this sounds like a form of warfare. The COVID policies have seemed like a biological warfare defense plan activated by NATO, etc. If there are multiple deliberate releases, then maybe the censorship and propaganda and lockdowns and mandates start to seem understandable?
Jul 14, 2022·edited Jul 14, 2022Liked by Brian Mowrey
Your writing is not plain. Dickensian mostly. Not that there's anything wrong with that!
So a bat virus, never found in a bat in the wild, has caused the madness. Meanwhile, a sister virus is also circulating, and folks' immune systems deal with that one. Because its a coronavirus that most people everywhere have been exposed to coronaviruses, but the original non-wild bat virus is still hovering and takes the weak/elderly/immunocompromised. But the immune system is key to mortality/hospitalization.
Thanks for this post. You were one of the original substackers when hell broke loose. You are a bonafide source - thanks Brian.
my friend, I love your work, but honestly, this post is a mess.
years of omicron evolution without sequences showing up, really?
Take a look at my blog if you you are interested in IMO more likely origin scenarios
https://www.stopgof.com/english/omicron-origin/
feedback appreciated!
The methodology in this paper -- for reconstructing phylogenetic tree by an ordering method that does not rely on a "clock" (eg as Trever Bedford does) -- might be interesting applied to the Omicron data. The paper gives what seems likely to be a much more accurate picture of the original root (which they find preceded original Wuhan strain) for the 2020 tree. Would like to see what the method finds for Omicron lineages. https://academic.oup.com/mbe/article/38/8/3046/6257226
Substack is where the conversation went that used to take place in the scientific literature, I guess. It's reassuring to see such thinking and explaining going on, as it includes self-doubt and allows for future correction based on more data. When contrasted with the top-down edicts of recent years, it makes one realize how amazingly corrupt it's become, as predicted by President Eisenhower in his Farewell Address.
so basically, all those bossche theories are just that ... a cover for spike protein.
This is all very interesting Brian. Like I stated in a comment from one of my posts, I wished I kept up with looking into Omicron. As soon as it appeared that things would end soon I stopped looking. Well, that was probably the wrong position to take!
I've been trying to relate Omicron and the current issue with the whole "immune invasion" or the more virulent nature of Ba.4/Ba.5. I think one of the only ways is to conceptualize Wuhan and Omicron lineages (being used loosely here) as distinct and to essentially decouple them from one another in order to address what's going on. That creates all sorts of problems, but I suppose that's what makes it a working model.
Anyways, great work! I think I should look deeper into the orf mutations- and mostly things outside of the spike as well.
Incredible posts like this is why I subscribe to your substack. Well done!
Are you familiar with the viral quasispecies theory? According to this theory, an infection is really an infection with many related viruses, which coexist in varying proportions. So if Ba.1 is predominant in the Qs, it mostly shows in sequencing and you may miss the lower prevalent ba.2 and ba.4 and ba.5.
But once immune landscape changes, other Qs members may gain higher prominence.
So, it is possible that they were all released as one quasispecies?
If some group is deliberately releasing variants, that might explain the extreme COVID policies. The lab leak theory is not new, but this sounds like a form of warfare. The COVID policies have seemed like a biological warfare defense plan activated by NATO, etc. If there are multiple deliberate releases, then maybe the censorship and propaganda and lockdowns and mandates start to seem understandable?
Your writing is not plain. Dickensian mostly. Not that there's anything wrong with that!
So a bat virus, never found in a bat in the wild, has caused the madness. Meanwhile, a sister virus is also circulating, and folks' immune systems deal with that one. Because its a coronavirus that most people everywhere have been exposed to coronaviruses, but the original non-wild bat virus is still hovering and takes the weak/elderly/immunocompromised. But the immune system is key to mortality/hospitalization.
Thanks for this post. You were one of the original substackers when hell broke loose. You are a bonafide source - thanks Brian.