I don't think a ribosome can see the 3' end when it starts translating an mRNA into a protein, so any short mRNAs transfected into your cells could be producing all sorts of weird stuff.
I do think lot to lot quality control is going to be implicated in the variability of outcomes. It's highly unlikely that the rush to mass production has produced anything like a controlled process for what, billions of doses? And what about contaminants coming along for the ride in different batches. What a bloody, greedy mess.
"Early in the pandemic many people noticed CDC C19 qPCR primers that hit Human DNA. Debunkers quickly reminded people that in order for PCR to amplify, you must have all 3 primers land in proximity (100-400bp) to one another. So single primer alignments to different distant locations in the genome could be ignored.
I don’t have any theory to offer, just some observations...!
I got 2 kittens from the same litter. They had vaccines at 8 weeks ( then the male developed a weird skin rash on face that vet hospital dermatologist couldn’t diagnose- it got better with iodine washes!) and again at 12 weeks. The male was castrated under GA at 4 months. At 6 months the male developed heart failure and required admission for 5 days being kept in an oxygen chamber. He had high troponin on day 6 and ultrasound diagnosed ‘transient myocardial thickening’. I was told this was often a reaction to a vaccine or anaesthetic and they were surprised at the time delay. He got better with diuretics and anti platelets. He’s nearly 4 now and always less springy when chasing a toy than my others and I’ve been told his life will be shortened. Cats are injected in the scruff of the neck, not into muscle. He didn’t have a covid vaccine so clearly any vaccine can cause myocarditis.
The smallpox/monkeypox vaccines all had a high risk of myocarditis in comparison with other vaccines.
The list of possible side effects for vaccines seem remarkably similar and across species too. My previous cat developed a lump in the neck after yearly repeat vaccinations and after googling I discovered sarcomas can occur. Apparently a particular dog vaccination ( given in US) is recommended now to be given in the leg so that if/when a sarcoma develops then they can just amputate the leg ( which you can’t do with the scruff of the neck)!
Sorry to hear about the cat's bad luck. Endlessly ethically complicated subjects, pets. [*looks at bruised and broken pinky from Airbnb house dog attack*]
Not sure about the smallpox vax myocarditis link. Not that I support the smallpox vax but I question how sturdy the evidence is. There were only a handful of recorded cases before the 2003 US military vax campaign. And none before 1955. Maybe it was underreported before organized study. But the numbers the 2015 study comes up with seem inconsistent. At all events it is just scraped on the shoulder, not injected.
You know, I honestly thought AMD was some kind of egomaniacal online fake persona. But that was a very compelling and informative explanation of the zeta potential thing. I think that is the right model for most modern vaccines with alum, positive charge in blood leads to glomming. The LNP-RNAs might be more complex.
I’ve just recently Audible’d the book Crooked by Forrest Marready ( after reading several excerpts on the substack of Unbekoming - an Australian) and I think I might get his other books. I think he might be on to something although I find it hard to concentrate when listening - I’m clearly a visual person, not auditory! I’m not entirely convinced but I think he may have some contributory factors.
I did watch some of the videos suggested by AMD in that post and it really struck home with regard to vaccines and SIDS. I’ve had 3 children and was terrified of SIDS as I didn’t know what caused it. Now I’m so peeved at the fear I went through.
Prior to covid I was researching how not to get dementia ( both parents and both in-laws have/had it to some degree) and I used to be a GP and my main takeaway from that career was that I never wanted to get ill enough to end up in the hands of a doctor! Dementia is multifactorial and addressing all the factors seems to help so I apply the same logic to vaccines. They must be multifactorial in their injuries and we need to look at everything, including, but not limited to, bolus theory. I can’t figure out why traditional vaccines lead to autoimmunity unless it is all due to the adjuvant. But I think some live attenuated do it too. I’ve also Audible’d Dissolving Illusions - but again I clearly don’t process information well whilst walking the dog in the woods! I have a hard copy of Turtles All The Way Down but by the time I’ve read my zillion substacks for the day, there is no time left for reading an actual book!
If all vaccines have similar side effects ( and a lot have poor efficacy? - would like to hear someone I respect try and debunk Dissolving Illusions to hear the other side of the story) then is it just the adjuvants or in the case of covid vaccines the adenovirus vectors or LNPs?
A few months ago I read _The Moth in the Iron Lung_, which led to _Crooked_ (both audiobooks as well -- these eyes are not so good), in pursuit of understanding what may have happened to me, and the author has some interesting ideas. I would like to see better confirmation, but when you don't have much of anything to go on anyway, well-reasoned speculation is better than nothing. The information about the cranial nerves was quite revealing. I will check out Unbekoming too. Thanks!
There's also the question of injected random environmental virus. Of course, that's also at play with regular injections, which I've argued is the actual explanation for the polio epidemic era. But who knows what else could be tied to inadvertent environmental injection, like weird epstein-barr outcomes etc.
But only with vaccines is it ok to inject toxic metals to make them work. Imagine if you tried to get a regular medicine approved and said, "well, we added the aluminum to give it that extra kick." But it seems like it wasn't a big deal with the prior norm of only getting a few injected vaccines in childhood (and using OPV, which was way better). So it's probably both cumulative and russian-roulete dynamics, and AMD puts the dynamics of acute local "blood sludge ischemia" events in a compelling light for explaining why.
But also, a big one, is the indirect harms of taking away viruses. We were co-evolved with them. Our genes aren't calibrated for sterility. For all we know, regular Measles exposure fights auto-immunity and cancer, essentially acting as the ref that red-flags both teams on that divide to keep our cells in balance. Too bad let's just make it go extinct.
My thought now is that more kids become autistic from MMR than died from measles. Growing up in the 60s we kids all got measles, mumps and chickenpox. I was the eldest of seven. My mother saw a lot of the inside of the house for each one of those as we quarantined. Interesting how each child in family had different experience too. A younger sister was covered with pox but I had to be told I had it to believe it. I counted one "pock" (is that the singular of pox?). A younger brother had a mildly fat face from mumps. Again I didn't feel like I got hit hard. What we didn't have were endless vaccines. And I don't remember ever encountering anyone called autistic. "Retarded" was the word then and we had them mainstreamed in public school. But they were friendly and good natured.
An interesting fact is that the rubella outbreak was the very next year after the mumps vax was licensed. I used to be able to link to the "History of Vaccines" timeline for this but the scrubbed the site. Too bad. Anyway I think Measles and Mumps are very important "best fits" for a certain niche of the virome, and without them we get these other bugs that hit after puberty and cause ME/CFS etc.
Autistic wasn't a word when I grew up either. But I think I would have been called it if it was, which is the funny part. I couldn't process speech outside of game and educational settings. I think I was just very poorly socialized but it's still funny that I would be labeled with a condition today. Anyway, so I don't know if it was the MMR (which I had) or just the expansion of the whole program (which I missed), or if chickenpox actually has genes that help make our brains socially function (could be).
Well for what it's worth I have a sister who's sure I have Asperger's.
One of the dreariest parts of modern life is how we slap a label on everyone for anything at all unpleasant. Yeah, I'm blunt and not very diplomatic and sometimes step in it. But label me and you know what? Pharma will have a drug for me in just a minute. And that will fix everything.
It's true that vaccines seem to have many injuries in common, such as GBS. Now throw in this new gene-tampering and the sky's the limit.
I love your description of your care and observation of your cats. So interesting. Your cats are so well cared for. Where I live they tend to be neglected, allowed to roam at large.
My ten year old German shepherd bitch is due for her rabies update. Every three years. She's with us all the time in the house and in a fenced yard. I'm debating blowing off the vaccine for her at her age. Really don't want to lose her. I know rabies is no joke but neither are these vaccines and no one will give a care if she dies, at this age.
Speaking of rabies vaccines, I have had them twice. Once as a child with the old vaccine, went into anaphylaxis and they had to stop and hope for the best. Again as an adult after a bat got tangled in hair and scratched scalp as I was running one night past a patch of woods. I had no adverse reaction to that series of shots (1985). Wondering what might happen these days: will mRNA be deemed suitable for rabies shots? Wow! What would the consequences be?
Vets are making a killing these days - wonder why? My cat received great care at great expense as unfortunately I’ve only ever insured the dog and not the 4 cats - as I thought they’d never get ill as the ones from my childhood lived healthily forever!
Rabies is a mysterious topic. I still can't grasp how the vaccine can improve outcomes being given after infection. Often wonder if it's just an illusion of cause and effect.
I never thought to question it very hard, just did as I was told (uncharacteristically). We have occasional rabies deaths of shelter workers very few and far between.
Hard for me to understand too. But the animal who scratched/bit may have inflicted the injury well before showing florid rabies symptoms, so the person never considered it could have been rabid. By the time you have symptoms it's almost always too late though back in the 1980s someone was nursed through rabies by treating her symptoms. She survived. (Don't have a link for that though.)
Raccoons infest chimneys around here in winter and raise pups in them. I think it's dangerous because their excrement can fall to the hearth and it can be contaminated. In one case in my in-laws house our Shepherd girl went over and took a little taste before I could stop her. Hey, she was then up to date on her shots. But we weren't...
I watched the first interview of Prof Robert Clancy by John Campbell on Campbell's channel. Clancy is an immunologist. What I took from the interview is that no one really understands all that the mRNA and AAV/DNA shots are doing in the body. They discussed different damage mechanisms; you can't help concluding it must be individualized.
Your fine analysis here of the small study reinforces that conclusion: we're conducting a risky experiment with truly rotten design on a large sector of the human race.
I never could understand how Girardot could claim similar damage came from prior vaccines hitting a vein.
I know. It's unlikely that any one factor is going to explain everything. You have individual humans and individual lots, as well as individual scrubbed-personnel jamming needles into arms with no aspiration. It would be hard to think of a sloppier approach to immunizing people.
With great respect, I congratulate you and your staff for the first, detailed publication on autopsy findings of five deceased (in temporal connection with the injection of mRNA drugs)!
I am confident and hopeful that your team will publish findings (including detection of modified mRNA and spike protein, and possibly detection of cationic lipids with MS/MS technology) not only for those who died of myocarditis in the period up to seven days, but also for the other patients.
More than a year ago, I addressed the myocarditis problem in adolescents (it involved the student body of our university) and our rector and his advisory team in several analyses (also publicly available). I attach two of these analyses. At that time, the toxic effects of LNPs (mediated via intracellular lipid receptors and caspase 1/11), as demonstrated by Ndeupen et al (1), were not yet known, which is why I had to limit myself to the interaction of the spike protein with TLR-4 (2). This turned out to be complex, as the spike protein can also bind LPS (analogous to CD14), according to Schmidtchen's group, and facilitates transfer to the receptor (3).
I have two comments on your publication:
1. accidental intravenous injection of BNT162b2 lipid nanoparticles as a cause of myocarditis?
Cited for the i.v. hypothesis is e.g. by you (4) and authorities a study in mice already presented by me in October 2021 in "Tip of the Iceberg: Part 1 and Part 2" (5). My assessment, supported by three decades of scientific cooperation with the pharmaceutical industry, is as follows:
Pfizer/Biontech, had, in my opinion, a significant influence on the content of the publication. The authors distract in the title, abstract, and text from results reported in Table 1 and in the "Supplemental Data" (Figure S 3)". Table 1 clearly shows that after two i.m. Injection, the same changes are observed in the myocardium as after a single i.v. injection. This is consistent with reports of adverse events demonstrating that the incidence is substantially higher after second injection. Interestingly, there is a lack of data on troponin levels after two i.m. Injection. In Figure S3, the authors show that BNT162b2 mRNA is found in nearly equal amounts in myocardial tissue on day 1 after both i.m. and i.v. injection.
Commentators, e.g. (6) have adopted the focus on "intravenous" - without asking much about the mechanism of toxic effect. Thus, it was implied and generally accepted that (only) intravenous, but by no means regulation, intramuscular injection (after aspiration) can cause myocarditis. In other words, negligence of physicians and/or authorities (frequently cited laudable exception is Denmark) but LNPs not containing BNT162b2mRNA are (co-)causative of myocarditis.
This raises the question of whether all 16 (15 + 1) subjects in the study were injected intravenously by (7), because the plasma levels of all are relatively uniform.
2.frequency of myocarditis after CARS-CoV-2 infection.
You cite (8) as an example. However, (9), for example, comes to different results.
With warm, collegial regards!
Your
H. Glossmann
References
1, Ndeupen S, Qin Z, Jacobsen S, Bouteau A, Estanbouli H, Igyártó BZ. The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory. iScience. 2021;24(12).
2. Yang G, Zhang S, Wang Y, Li L, Li Y, Yuan D, et al. Aptamer blocking S-TLR4 interaction selectively inhibits SARS-CoV-2 induced inflammation. Signal Transduct Target Ther. 2022;7(1):4-6.
4. Schwab C, Domke LM, Hartmann L, Stenzinger A, Longerich T, Schirmacher P. Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination. Clinical Research in Cardiology [Internet]. 2022;(December 2020). Available from: https://doi.org/10.1007/s00392-022-02129-5
5, Li C, Chen Y, Zhao Y, Lung DC, Ye Z, Song W, et al. Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model. Clinical Infectious Diseases [Internet]. 2021 Aug 18;2019(Xx Xxxx):1-18. Available from: https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab707/6353927
6 Rzymski P, Fal A. To aspirate or not to aspirate? Considerations for the COVID-19 vaccines. Pharmacological Reports [Internet]. 2022;74(6):1223-7. Available from: https://doi.org/10.1007/s43440-022-00361-4
7. Fertig TE, Chitoiu L, Marta DS, Ionescu VS, Cismasiu VB, Radu E, et al. Vaccine mRNA Can Be Detected in Blood at 15 Days Post-Vaccination. Biomedicines. 2022;10(7):1-11.
8 Heymans S, Cooper LT. Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms. Nat Rev Cardiol. 2022;19(2):75-7.
9. Tuvali O, Tshori S, Derazne E, Hannuna RR, Afek A, Haberman D, et al. The Incidence of Myocarditis and Pericarditis in Post COVID-19 Unvaccinated Patients-A Large Population-Based Study. J Clin Med. 2022;11(8).
Of course! Pathologists, such as the laboratory of Prof.Schirmacher in Heidelberg, can perform very sensitive and non-destructive probes:
1. In Situ detection by means of immunohistochemistry not only for intact spike protein, but for S1 and S2 as well. Further confirmation of the causality chain of molecular events (host response) can be performed (e.g. activation pathways for the unfolded protein response, of innate immunity, activation of the complement cascade[10.1093/brain/awac311] etc.) Standardized protocols have been published by Nuovo et al. ( 10.1097/PAI.0000000000000992). To the best of my knowledge, the laboratory of Cynthia Magro is outstanding worldwide in this respect. Her laboratory was the first to demonstrate spike protein together with caspase and IL-6 in micro vessel inner linings (anywhere throughout the body!) in skin biopsies weeks after the injections. She also mentions a case of myocarditis……
2.Destructive methods: MALDI-MS and related methods(10.1016/j.trac.2022.116759), applied to tissue slices. Note: there are also nondestructive methods to analyze drugs and other small molecules in tissue slices-but they of no relevance for the spike protein but for the lipid content of the LNPs here. Example for MS technology: The laboratory of Bruce P. Patterson has published on the detection of spike protein in circulating monocytes up to 15 months after infection and another paper about “vaccinated= injected” (but with no history of SARS-CoV 2 infection) is apparently under review. Therefore, alternative methods to immunohistochemistry exist and may help to get additional “forensic” evidence. Possible findings with increased activation of inflammatory cascades induced via spike protein are complicated by the inflammatory cationic lipid (which serve an adjuvant function). The detection of the proprietary lipid and PEG in the autopsy ( or biopsy) tissue by MS/MS appears to be feasible.
With respect to the mouse iv ,im injection paper ,very often cited as to blame physicians for having not aspirated( and thereby causing myocarditis) pls note that there was an MTA between Pfizer and the authors.The drug (with a batch number )was obtained from the company. Clearly ,the entire paper was written to give the impression that it is the doctors`fault. Even official health agencies have cited this nonsense.The effects of the first injection ( either im or iv) cannot be due to adaptive immunity. And twice the i.m. dose. has the same result as one time iv.By the way, the im injected mice suffered the greatest loss of weight ( not discussed by the authors). Moreover, any troponin data are not reported for the second shot.The paper mentioned the toxic effects of (only) nasal application of empty LNPs (Sonja Ndeupen et al.) However, they did not report (or performed ?) the correct controls- empty LNPs.Pfizer knew about the myocarditis risk . We do know :it is dose-dependent, second injection is apparently amplifying damage of the first shot, females are about 4 to 5 times less vulnerable compared to males -in the age range of 6-25 years.I have suspected a role of TLR-4 ,which is a well characterized target for the trimeric spike of Sars-Cov 2( not for Sars-Cov1 or other relatives!).
In any event,I recently summarized the strategy of the pharmaceutical companies to counterattack concerns about the myocarditis risk as follows:
1.The Covid -19 "disease" has a 1000-fold higher risk and people may die from it
2.In contrast to Covid-19 , myocarditis after the shot is very rare ,very mild, transient and can be easily treated
3.The most cynical explanation is that the medics did not aspirate( "To aspirate or not to aspirate ? ")
I agree (and maybe Joomi would, if more inclined to open conspiracy-theorizing) that the paper seems like a likely op to deflect from intrinsic myocarditis risk. So, for all we know, might Girardot's bolus theory be.
I think in consideration of choppy RNA we would have to look and see whether there are cellular responses to halt such a production. I mentioned it a while back, but apparently a majority of the proteins that our cells produce are misfolded and require editing, so I'm curious if truncated proteins would be recognized and dealt with.
I suppose that's why other viral proteins are helpful since they help to shut down those regulatory processes.
But in any case, this is frustrating because choppy spike would seem like one of the easiest things to isolate.
As to bolus, I remember the mouse studies and the general worry about not aerating during vaccination, but that seems to have disappeared as well. I believe Dr. Malone assuaged concerns over IV injection with, "trust me", sort of. Not to denigrate Dr. Malone, but it was a strange remark given that it's quite possible out of the millions of doses that a good deal of people received IV injections accidentally due to statistical probably alone.
I think it's worth considering which cells are actually taking up the mRNA as well. Adipocytes are full of fat, but are they good at producing proteins? With the adenoviral vectors that use DNA muscles are multinucleated, so are they getting a few hits with those vaccines? There's a ton of ambiguity going on here and so much to consider.
I do appreciate that you dived in and tried to piece together your perspective. This tells us we need far more research to figure out what's going on.
The majority are misfolded, or are just not finished folding yet? Rough ER processes? I'm just beginning to try to make sense of the goings-on at this level. At this point in my reading, it does look like there could be opportunities to detect a missing 3' end and dispose of the strand. But where do viral mRNA proteins do their folding?
Basic housekeeping / RNAse should serve to "halt" expression of truncated RNAs. In theory.
Viruses might instead seek to amp up intrinsic anti-RNA-expression factors, effectively making cells RNA-hostile, to shut off immune response and favor their own "heavy-duty" RNAs.
"Poliovirus, a non-enveloped virus and a member of the family of Picornaviridae alters intracellular monovalent ion concentrations during infection. An increased total cell volume correlating with increased [Na+]i and decreased [K+]i is detected after a couple hours post infection with poliovirus, and has the effect of decreasing the overall rate of protein synthesis of infected cells [112,113,120]. Mammalian cells are known to be sensitive to changes in intracellular monovalent ion concentrations during translation of cellular mRNA [69,127]. Certain viral mRNA, including poliovirus mRNA, has been shown to be less sensitive to altered intracellular cation concentrations. This presents a mechanism by which viruses coax the host cell to preferentially translate viral RNA over most cellular RNA. A decrease in the [NaCl] or an increase in the [KCl] in the medium of infected cells is able to compensate for the induced alterations of intracellular monovalent cation concentrations and allow infected cells to resume normal protein synthesis"
I second Richard Sharpe's comment that your diagrams in this case were really excellent and helped make it all more understandable. Thank you also for at least considering Marc G. for a trophy, even if his theory is only, maybe, partially explanatory.
It's a treat to see you working your way through the various hypotheses - this is how science is done! Even those readers who don't fully understand what is being described should be able to realize, by seeing how unsettled the science is, that everyone involved in every aspect of the mRNA transfection drive was way, way over their skis as they jumped off the ramp at Mt. Hubris.
They have antibodies to spike. It might simply be that S2-binding antibodies are not self-competing. So you can still get a labeled antibody to stick to S2 even if there's already some antibody there. Especially if the early post-vaccine S2 antibodies are not high-affinity.
Whereas, because the S1 and RBD are immunodominant, affinity maturation proceeds more quickly and before you've even had the second injection S1 antibodies will mask S1.
but there's hardly any difference once it's washed with dtt.... so all they really detected was free spike and nothing bound to an antibody............. or does their test detect free even if the spike has a low affinity antibody clinging on to it ? In which case do heart cells have that receptor to allow ADE entry......... I remember reading that some people due to a genetic defect don't make antibodies (or very poor ones)...... could these myo kids be such?
There would only be a difference in detected spike post-DTT if S2 antibodies were blocking detection to begin with. But blocking other antibodies isn't necessarily part of the "mandate" of antibodies. So like I say it's like antigen polygamy, just because you can add another antibody "wife" doesn't mean the antigen "husband" didn't have any wives to begin with. But taking away wives from husbands doesn't create more husbands. But that's just how I interpreted the results, maybe it's incorrect.
LNPs do not require ADE for entry, they can get into any cell. They will tend to get into endothelial cells and cells in tissues with fenestrated capillaries (like glands), per theory. (BioNTech's Sahin authored this one, Figure 5 shows expected dispersion based on capillary fenestration https://www.nature.com/articles/nrd4278 )
huh?? Are you saying they detected spike wrapped in LNP? Thought it was just free and promiscuous like the S1....... freed from the cell ready to mate with the ACE or whatever..... especially if it had a loose antibody hanging on and helping it.
Are you saying there may be antibodies hanging on but not blocking it pre DTT....? Wouldn't that explain the myo? Free spike ADE blah de blah
No, just a reading comprehension error on my part. The substack comment font is too tiny and I was cooking dinner. I mixed "ADE" and "ACE-2" in my head. So disregard that part of my last reply.
Hmmm to what journal, if not their own( fox guarding chickens) do harmaceuticals send a paper?
According to the info gleaned from the very poorly done study with unknown numbers of mice, that prestigious journal The Journal of Irreproducible Results must be thick these days.
Damn, your diagrams are great. How do you come up with them? I liked the one with the hammers and wrenches (from a previous posting)!
Anyway, until we have a characterization of all the proteins that might be being made by the transfected mRNA (partial and full) we might not be able to say with certainty what is going on.
Interleukin +/- age-related vaccine response impacts also discussed here: https://twitter.com/Clucky92864053/status/1643647717367857153
I don't think a ribosome can see the 3' end when it starts translating an mRNA into a protein, so any short mRNAs transfected into your cells could be producing all sorts of weird stuff.
I do think lot to lot quality control is going to be implicated in the variability of outcomes. It's highly unlikely that the rush to mass production has produced anything like a controlled process for what, billions of doses? And what about contaminants coming along for the ride in different batches. What a bloody, greedy mess.
Of interest to the question of PCR false positives:
https://anandamide.substack.com/p/lariats-and-rna-splicing
Money quote:
"Early in the pandemic many people noticed CDC C19 qPCR primers that hit Human DNA. Debunkers quickly reminded people that in order for PCR to amplify, you must have all 3 primers land in proximity (100-400bp) to one another. So single primer alignments to different distant locations in the genome could be ignored.
Fact Check: True for DNA. False for RNA."
Right, the big point there is that some assays were authorized without doing real cross-reactivity panels. But others used panels.
I don’t have any theory to offer, just some observations...!
I got 2 kittens from the same litter. They had vaccines at 8 weeks ( then the male developed a weird skin rash on face that vet hospital dermatologist couldn’t diagnose- it got better with iodine washes!) and again at 12 weeks. The male was castrated under GA at 4 months. At 6 months the male developed heart failure and required admission for 5 days being kept in an oxygen chamber. He had high troponin on day 6 and ultrasound diagnosed ‘transient myocardial thickening’. I was told this was often a reaction to a vaccine or anaesthetic and they were surprised at the time delay. He got better with diuretics and anti platelets. He’s nearly 4 now and always less springy when chasing a toy than my others and I’ve been told his life will be shortened. Cats are injected in the scruff of the neck, not into muscle. He didn’t have a covid vaccine so clearly any vaccine can cause myocarditis.
The smallpox/monkeypox vaccines all had a high risk of myocarditis in comparison with other vaccines.
The list of possible side effects for vaccines seem remarkably similar and across species too. My previous cat developed a lump in the neck after yearly repeat vaccinations and after googling I discovered sarcomas can occur. Apparently a particular dog vaccination ( given in US) is recommended now to be given in the leg so that if/when a sarcoma develops then they can just amputate the leg ( which you can’t do with the scruff of the neck)!
Have you seen this post by A Midwestern Doctor
https://amidwesterndoctor.substack.com/p/why-does-every-vaccine-often-cause
Which has a unifying theory of why all vaccines are a problem ( bolus or not)?
Sorry to hear about the cat's bad luck. Endlessly ethically complicated subjects, pets. [*looks at bruised and broken pinky from Airbnb house dog attack*]
Not sure about the smallpox vax myocarditis link. Not that I support the smallpox vax but I question how sturdy the evidence is. There were only a handful of recorded cases before the 2003 US military vax campaign. And none before 1955. Maybe it was underreported before organized study. But the numbers the 2015 study comes up with seem inconsistent. At all events it is just scraped on the shoulder, not injected.
You know, I honestly thought AMD was some kind of egomaniacal online fake persona. But that was a very compelling and informative explanation of the zeta potential thing. I think that is the right model for most modern vaccines with alum, positive charge in blood leads to glomming. The LNP-RNAs might be more complex.
I’ve just recently Audible’d the book Crooked by Forrest Marready ( after reading several excerpts on the substack of Unbekoming - an Australian) and I think I might get his other books. I think he might be on to something although I find it hard to concentrate when listening - I’m clearly a visual person, not auditory! I’m not entirely convinced but I think he may have some contributory factors.
I did watch some of the videos suggested by AMD in that post and it really struck home with regard to vaccines and SIDS. I’ve had 3 children and was terrified of SIDS as I didn’t know what caused it. Now I’m so peeved at the fear I went through.
Prior to covid I was researching how not to get dementia ( both parents and both in-laws have/had it to some degree) and I used to be a GP and my main takeaway from that career was that I never wanted to get ill enough to end up in the hands of a doctor! Dementia is multifactorial and addressing all the factors seems to help so I apply the same logic to vaccines. They must be multifactorial in their injuries and we need to look at everything, including, but not limited to, bolus theory. I can’t figure out why traditional vaccines lead to autoimmunity unless it is all due to the adjuvant. But I think some live attenuated do it too. I’ve also Audible’d Dissolving Illusions - but again I clearly don’t process information well whilst walking the dog in the woods! I have a hard copy of Turtles All The Way Down but by the time I’ve read my zillion substacks for the day, there is no time left for reading an actual book!
If all vaccines have similar side effects ( and a lot have poor efficacy? - would like to hear someone I respect try and debunk Dissolving Illusions to hear the other side of the story) then is it just the adjuvants or in the case of covid vaccines the adenovirus vectors or LNPs?
A few months ago I read _The Moth in the Iron Lung_, which led to _Crooked_ (both audiobooks as well -- these eyes are not so good), in pursuit of understanding what may have happened to me, and the author has some interesting ideas. I would like to see better confirmation, but when you don't have much of anything to go on anyway, well-reasoned speculation is better than nothing. The information about the cranial nerves was quite revealing. I will check out Unbekoming too. Thanks!
There's also the question of injected random environmental virus. Of course, that's also at play with regular injections, which I've argued is the actual explanation for the polio epidemic era. But who knows what else could be tied to inadvertent environmental injection, like weird epstein-barr outcomes etc.
But only with vaccines is it ok to inject toxic metals to make them work. Imagine if you tried to get a regular medicine approved and said, "well, we added the aluminum to give it that extra kick." But it seems like it wasn't a big deal with the prior norm of only getting a few injected vaccines in childhood (and using OPV, which was way better). So it's probably both cumulative and russian-roulete dynamics, and AMD puts the dynamics of acute local "blood sludge ischemia" events in a compelling light for explaining why.
But also, a big one, is the indirect harms of taking away viruses. We were co-evolved with them. Our genes aren't calibrated for sterility. For all we know, regular Measles exposure fights auto-immunity and cancer, essentially acting as the ref that red-flags both teams on that divide to keep our cells in balance. Too bad let's just make it go extinct.
My thought now is that more kids become autistic from MMR than died from measles. Growing up in the 60s we kids all got measles, mumps and chickenpox. I was the eldest of seven. My mother saw a lot of the inside of the house for each one of those as we quarantined. Interesting how each child in family had different experience too. A younger sister was covered with pox but I had to be told I had it to believe it. I counted one "pock" (is that the singular of pox?). A younger brother had a mildly fat face from mumps. Again I didn't feel like I got hit hard. What we didn't have were endless vaccines. And I don't remember ever encountering anyone called autistic. "Retarded" was the word then and we had them mainstreamed in public school. But they were friendly and good natured.
An interesting fact is that the rubella outbreak was the very next year after the mumps vax was licensed. I used to be able to link to the "History of Vaccines" timeline for this but the scrubbed the site. Too bad. Anyway I think Measles and Mumps are very important "best fits" for a certain niche of the virome, and without them we get these other bugs that hit after puberty and cause ME/CFS etc.
Autistic wasn't a word when I grew up either. But I think I would have been called it if it was, which is the funny part. I couldn't process speech outside of game and educational settings. I think I was just very poorly socialized but it's still funny that I would be labeled with a condition today. Anyway, so I don't know if it was the MMR (which I had) or just the expansion of the whole program (which I missed), or if chickenpox actually has genes that help make our brains socially function (could be).
Well for what it's worth I have a sister who's sure I have Asperger's.
One of the dreariest parts of modern life is how we slap a label on everyone for anything at all unpleasant. Yeah, I'm blunt and not very diplomatic and sometimes step in it. But label me and you know what? Pharma will have a drug for me in just a minute. And that will fix everything.
https://www.bitchute.com/video/SAHQoZEqnFB5/
Here is an interview with Andy Wakefield discussing the no win situation we’ve created with an ineffective measles vaccine.
It's true that vaccines seem to have many injuries in common, such as GBS. Now throw in this new gene-tampering and the sky's the limit.
I love your description of your care and observation of your cats. So interesting. Your cats are so well cared for. Where I live they tend to be neglected, allowed to roam at large.
My ten year old German shepherd bitch is due for her rabies update. Every three years. She's with us all the time in the house and in a fenced yard. I'm debating blowing off the vaccine for her at her age. Really don't want to lose her. I know rabies is no joke but neither are these vaccines and no one will give a care if she dies, at this age.
Speaking of rabies vaccines, I have had them twice. Once as a child with the old vaccine, went into anaphylaxis and they had to stop and hope for the best. Again as an adult after a bat got tangled in hair and scratched scalp as I was running one night past a patch of woods. I had no adverse reaction to that series of shots (1985). Wondering what might happen these days: will mRNA be deemed suitable for rabies shots? Wow! What would the consequences be?
Vets are making a killing these days - wonder why? My cat received great care at great expense as unfortunately I’ve only ever insured the dog and not the 4 cats - as I thought they’d never get ill as the ones from my childhood lived healthily forever!
Rabies is a mysterious topic. I still can't grasp how the vaccine can improve outcomes being given after infection. Often wonder if it's just an illusion of cause and effect.
I never thought to question it very hard, just did as I was told (uncharacteristically). We have occasional rabies deaths of shelter workers very few and far between.
Despite vaxxing afterward? I guess it's easier to miss/forget a scratch/bite if you are increasing how often you get scratched and bit.
Hard for me to understand too. But the animal who scratched/bit may have inflicted the injury well before showing florid rabies symptoms, so the person never considered it could have been rabid. By the time you have symptoms it's almost always too late though back in the 1980s someone was nursed through rabies by treating her symptoms. She survived. (Don't have a link for that though.)
Raccoons infest chimneys around here in winter and raise pups in them. I think it's dangerous because their excrement can fall to the hearth and it can be contaminated. In one case in my in-laws house our Shepherd girl went over and took a little taste before I could stop her. Hey, she was then up to date on her shots. But we weren't...
I watched the first interview of Prof Robert Clancy by John Campbell on Campbell's channel. Clancy is an immunologist. What I took from the interview is that no one really understands all that the mRNA and AAV/DNA shots are doing in the body. They discussed different damage mechanisms; you can't help concluding it must be individualized.
Your fine analysis here of the small study reinforces that conclusion: we're conducting a risky experiment with truly rotten design on a large sector of the human race.
I never could understand how Girardot could claim similar damage came from prior vaccines hitting a vein.
But hey, your wit always makes me laugh anyway.
A lot of people fall into the "immune overreaction explains everything" worldview.
I know. It's unlikely that any one factor is going to explain everything. You have individual humans and individual lots, as well as individual scrubbed-personnel jamming needles into arms with no aspiration. It would be hard to think of a sloppier approach to immunizing people.
On December 11th 2022 I wrote a letter ( below, Deeple translated ) to Prof.Schirmacher-but received no answer up to today.
Em.o.Univ.-Prof. Dr. med. Hartmut Glossmann
Specialist in pharmacology / clinical pharmacology
Institute for Biochemical Pharmacology
Peter Mayr-Str. 1
6020 Innsbruck
+43 512 9003 70400
+43 660 140 37 26 (mobile)
+43 512 9003 73400 (FAX)
Hartmut.Glossmann@i-med.ac.at
www.i-med.ac.at/ibp/ <http://www.i-med.ac.at/ibp/>
Dear Dr. Schirmacher,
With great respect, I congratulate you and your staff for the first, detailed publication on autopsy findings of five deceased (in temporal connection with the injection of mRNA drugs)!
I am confident and hopeful that your team will publish findings (including detection of modified mRNA and spike protein, and possibly detection of cationic lipids with MS/MS technology) not only for those who died of myocarditis in the period up to seven days, but also for the other patients.
More than a year ago, I addressed the myocarditis problem in adolescents (it involved the student body of our university) and our rector and his advisory team in several analyses (also publicly available). I attach two of these analyses. At that time, the toxic effects of LNPs (mediated via intracellular lipid receptors and caspase 1/11), as demonstrated by Ndeupen et al (1), were not yet known, which is why I had to limit myself to the interaction of the spike protein with TLR-4 (2). This turned out to be complex, as the spike protein can also bind LPS (analogous to CD14), according to Schmidtchen's group, and facilitates transfer to the receptor (3).
I have two comments on your publication:
1. accidental intravenous injection of BNT162b2 lipid nanoparticles as a cause of myocarditis?
Cited for the i.v. hypothesis is e.g. by you (4) and authorities a study in mice already presented by me in October 2021 in "Tip of the Iceberg: Part 1 and Part 2" (5). My assessment, supported by three decades of scientific cooperation with the pharmaceutical industry, is as follows:
Pfizer/Biontech, had, in my opinion, a significant influence on the content of the publication. The authors distract in the title, abstract, and text from results reported in Table 1 and in the "Supplemental Data" (Figure S 3)". Table 1 clearly shows that after two i.m. Injection, the same changes are observed in the myocardium as after a single i.v. injection. This is consistent with reports of adverse events demonstrating that the incidence is substantially higher after second injection. Interestingly, there is a lack of data on troponin levels after two i.m. Injection. In Figure S3, the authors show that BNT162b2 mRNA is found in nearly equal amounts in myocardial tissue on day 1 after both i.m. and i.v. injection.
Commentators, e.g. (6) have adopted the focus on "intravenous" - without asking much about the mechanism of toxic effect. Thus, it was implied and generally accepted that (only) intravenous, but by no means regulation, intramuscular injection (after aspiration) can cause myocarditis. In other words, negligence of physicians and/or authorities (frequently cited laudable exception is Denmark) but LNPs not containing BNT162b2mRNA are (co-)causative of myocarditis.
This raises the question of whether all 16 (15 + 1) subjects in the study were injected intravenously by (7), because the plasma levels of all are relatively uniform.
2.frequency of myocarditis after CARS-CoV-2 infection.
You cite (8) as an example. However, (9), for example, comes to different results.
With warm, collegial regards!
Your
H. Glossmann
References
1, Ndeupen S, Qin Z, Jacobsen S, Bouteau A, Estanbouli H, Igyártó BZ. The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory. iScience. 2021;24(12).
2. Yang G, Zhang S, Wang Y, Li L, Li Y, Yuan D, et al. Aptamer blocking S-TLR4 interaction selectively inhibits SARS-CoV-2 induced inflammation. Signal Transduct Target Ther. 2022;7(1):4-6.
3. Samsudin F, Raghuvamsi P, Petruk G, Puthia M, Petrlova J, MacAry P, et al. SARS-CoV-2 spike protein as a bacterial lipopolysaccharide delivery system in an overzealous inflammatory cascade. J Mol Cell Biol [Internet]. 2022 Oct 14;186(2):227-36. Available from: https://watermark.silverchair.com/mjac058.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAtswggLXBgkqhkiG9w0BBwagggLIMIICxAIBADCCAr0GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMyseyyEHscJbGjWuqAgEQgIICjpisr7_V8NMnpA_qkSM-0us0RgmdN7OnHez9YXnbg3ZzJB1
4. Schwab C, Domke LM, Hartmann L, Stenzinger A, Longerich T, Schirmacher P. Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination. Clinical Research in Cardiology [Internet]. 2022;(December 2020). Available from: https://doi.org/10.1007/s00392-022-02129-5
5, Li C, Chen Y, Zhao Y, Lung DC, Ye Z, Song W, et al. Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model. Clinical Infectious Diseases [Internet]. 2021 Aug 18;2019(Xx Xxxx):1-18. Available from: https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab707/6353927
6 Rzymski P, Fal A. To aspirate or not to aspirate? Considerations for the COVID-19 vaccines. Pharmacological Reports [Internet]. 2022;74(6):1223-7. Available from: https://doi.org/10.1007/s43440-022-00361-4
7. Fertig TE, Chitoiu L, Marta DS, Ionescu VS, Cismasiu VB, Radu E, et al. Vaccine mRNA Can Be Detected in Blood at 15 Days Post-Vaccination. Biomedicines. 2022;10(7):1-11.
8 Heymans S, Cooper LT. Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms. Nat Rev Cardiol. 2022;19(2):75-7.
9. Tuvali O, Tshori S, Derazne E, Hannuna RR, Afek A, Haberman D, et al. The Incidence of Myocarditis and Pericarditis in Post COVID-19 Unvaccinated Patients-A Large Population-Based Study. J Clin Med. 2022;11(8).
Can the pathologists check for presence of S1 only vs both S1 and S2 in the tissue samples they have got from the suddenly departed?
Of course! Pathologists, such as the laboratory of Prof.Schirmacher in Heidelberg, can perform very sensitive and non-destructive probes:
1. In Situ detection by means of immunohistochemistry not only for intact spike protein, but for S1 and S2 as well. Further confirmation of the causality chain of molecular events (host response) can be performed (e.g. activation pathways for the unfolded protein response, of innate immunity, activation of the complement cascade[10.1093/brain/awac311] etc.) Standardized protocols have been published by Nuovo et al. ( 10.1097/PAI.0000000000000992). To the best of my knowledge, the laboratory of Cynthia Magro is outstanding worldwide in this respect. Her laboratory was the first to demonstrate spike protein together with caspase and IL-6 in micro vessel inner linings (anywhere throughout the body!) in skin biopsies weeks after the injections. She also mentions a case of myocarditis……
2.Destructive methods: MALDI-MS and related methods(10.1016/j.trac.2022.116759), applied to tissue slices. Note: there are also nondestructive methods to analyze drugs and other small molecules in tissue slices-but they of no relevance for the spike protein but for the lipid content of the LNPs here. Example for MS technology: The laboratory of Bruce P. Patterson has published on the detection of spike protein in circulating monocytes up to 15 months after infection and another paper about “vaccinated= injected” (but with no history of SARS-CoV 2 infection) is apparently under review. Therefore, alternative methods to immunohistochemistry exist and may help to get additional “forensic” evidence. Possible findings with increased activation of inflammatory cascades induced via spike protein are complicated by the inflammatory cationic lipid (which serve an adjuvant function). The detection of the proprietary lipid and PEG in the autopsy ( or biopsy) tissue by MS/MS appears to be feasible.
With respect to the mouse iv ,im injection paper ,very often cited as to blame physicians for having not aspirated( and thereby causing myocarditis) pls note that there was an MTA between Pfizer and the authors.The drug (with a batch number )was obtained from the company. Clearly ,the entire paper was written to give the impression that it is the doctors`fault. Even official health agencies have cited this nonsense.The effects of the first injection ( either im or iv) cannot be due to adaptive immunity. And twice the i.m. dose. has the same result as one time iv.By the way, the im injected mice suffered the greatest loss of weight ( not discussed by the authors). Moreover, any troponin data are not reported for the second shot.The paper mentioned the toxic effects of (only) nasal application of empty LNPs (Sonja Ndeupen et al.) However, they did not report (or performed ?) the correct controls- empty LNPs.Pfizer knew about the myocarditis risk . We do know :it is dose-dependent, second injection is apparently amplifying damage of the first shot, females are about 4 to 5 times less vulnerable compared to males -in the age range of 6-25 years.I have suspected a role of TLR-4 ,which is a well characterized target for the trimeric spike of Sars-Cov 2( not for Sars-Cov1 or other relatives!).
In any event,I recently summarized the strategy of the pharmaceutical companies to counterattack concerns about the myocarditis risk as follows:
1.The Covid -19 "disease" has a 1000-fold higher risk and people may die from it
2.In contrast to Covid-19 , myocarditis after the shot is very rare ,very mild, transient and can be easily treated
3.The most cynical explanation is that the medics did not aspirate( "To aspirate or not to aspirate ? ")
I agree (and maybe Joomi would, if more inclined to open conspiracy-theorizing) that the paper seems like a likely op to deflect from intrinsic myocarditis risk. So, for all we know, might Girardot's bolus theory be.
I think in consideration of choppy RNA we would have to look and see whether there are cellular responses to halt such a production. I mentioned it a while back, but apparently a majority of the proteins that our cells produce are misfolded and require editing, so I'm curious if truncated proteins would be recognized and dealt with.
I suppose that's why other viral proteins are helpful since they help to shut down those regulatory processes.
But in any case, this is frustrating because choppy spike would seem like one of the easiest things to isolate.
As to bolus, I remember the mouse studies and the general worry about not aerating during vaccination, but that seems to have disappeared as well. I believe Dr. Malone assuaged concerns over IV injection with, "trust me", sort of. Not to denigrate Dr. Malone, but it was a strange remark given that it's quite possible out of the millions of doses that a good deal of people received IV injections accidentally due to statistical probably alone.
I think it's worth considering which cells are actually taking up the mRNA as well. Adipocytes are full of fat, but are they good at producing proteins? With the adenoviral vectors that use DNA muscles are multinucleated, so are they getting a few hits with those vaccines? There's a ton of ambiguity going on here and so much to consider.
I do appreciate that you dived in and tried to piece together your perspective. This tells us we need far more research to figure out what's going on.
The majority are misfolded, or are just not finished folding yet? Rough ER processes? I'm just beginning to try to make sense of the goings-on at this level. At this point in my reading, it does look like there could be opportunities to detect a missing 3' end and dispose of the strand. But where do viral mRNA proteins do their folding?
Basic housekeeping / RNAse should serve to "halt" expression of truncated RNAs. In theory.
Viruses might instead seek to amp up intrinsic anti-RNA-expression factors, effectively making cells RNA-hostile, to shut off immune response and favor their own "heavy-duty" RNAs.
"Poliovirus, a non-enveloped virus and a member of the family of Picornaviridae alters intracellular monovalent ion concentrations during infection. An increased total cell volume correlating with increased [Na+]i and decreased [K+]i is detected after a couple hours post infection with poliovirus, and has the effect of decreasing the overall rate of protein synthesis of infected cells [112,113,120]. Mammalian cells are known to be sensitive to changes in intracellular monovalent ion concentrations during translation of cellular mRNA [69,127]. Certain viral mRNA, including poliovirus mRNA, has been shown to be less sensitive to altered intracellular cation concentrations. This presents a mechanism by which viruses coax the host cell to preferentially translate viral RNA over most cellular RNA. A decrease in the [NaCl] or an increase in the [KCl] in the medium of infected cells is able to compensate for the induced alterations of intracellular monovalent cation concentrations and allow infected cells to resume normal protein synthesis"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174939/
Being somewhat (science) illiterate myself. I always read the comments to "tell me" what you said. It's early yet I will check back tomorrow.
You had me at "stochastically"....
I second Richard Sharpe's comment that your diagrams in this case were really excellent and helped make it all more understandable. Thank you also for at least considering Marc G. for a trophy, even if his theory is only, maybe, partially explanatory.
It's a treat to see you working your way through the various hypotheses - this is how science is done! Even those readers who don't fully understand what is being described should be able to realize, by seeing how unsettled the science is, that everyone involved in every aspect of the mRNA transfection drive was way, way over their skis as they jumped off the ramp at Mt. Hubris.
Thanks for the kind remarks on the figures!
Just remember that all broken legs experienced at Mt Hubris Lodge and Resort are caused by Long Covid.
but why would the myo kids have antibodies to S1 yet none (or not enough) to spike when S1 is part of spike???
They have antibodies to spike. It might simply be that S2-binding antibodies are not self-competing. So you can still get a labeled antibody to stick to S2 even if there's already some antibody there. Especially if the early post-vaccine S2 antibodies are not high-affinity.
Whereas, because the S1 and RBD are immunodominant, affinity maturation proceeds more quickly and before you've even had the second injection S1 antibodies will mask S1.
but there's hardly any difference once it's washed with dtt.... so all they really detected was free spike and nothing bound to an antibody............. or does their test detect free even if the spike has a low affinity antibody clinging on to it ? In which case do heart cells have that receptor to allow ADE entry......... I remember reading that some people due to a genetic defect don't make antibodies (or very poor ones)...... could these myo kids be such?
There would only be a difference in detected spike post-DTT if S2 antibodies were blocking detection to begin with. But blocking other antibodies isn't necessarily part of the "mandate" of antibodies. So like I say it's like antigen polygamy, just because you can add another antibody "wife" doesn't mean the antigen "husband" didn't have any wives to begin with. But taking away wives from husbands doesn't create more husbands. But that's just how I interpreted the results, maybe it's incorrect.
LNPs do not require ADE for entry, they can get into any cell. They will tend to get into endothelial cells and cells in tissues with fenestrated capillaries (like glands), per theory. (BioNTech's Sahin authored this one, Figure 5 shows expected dispersion based on capillary fenestration https://www.nature.com/articles/nrd4278 )
huh?? Are you saying they detected spike wrapped in LNP? Thought it was just free and promiscuous like the S1....... freed from the cell ready to mate with the ACE or whatever..... especially if it had a loose antibody hanging on and helping it.
Are you saying there may be antibodies hanging on but not blocking it pre DTT....? Wouldn't that explain the myo? Free spike ADE blah de blah
No, just a reading comprehension error on my part. The substack comment font is too tiny and I was cooking dinner. I mixed "ADE" and "ACE-2" in my head. So disregard that part of my last reply.
Hmmm to what journal, if not their own( fox guarding chickens) do harmaceuticals send a paper?
According to the info gleaned from the very poorly done study with unknown numbers of mice, that prestigious journal The Journal of Irreproducible Results must be thick these days.
We'd be better off putting the CEOs on stage to sing cover songs and voting for the best one with our phones.
Damn, your diagrams are great. How do you come up with them? I liked the one with the hammers and wrenches (from a previous posting)!
Anyway, until we have a characterization of all the proteins that might be being made by the transfected mRNA (partial and full) we might not be able to say with certainty what is going on.
I work with whatever is in the Pages app, haha. It's a weirdly limited pallet. Actually I literally have to use a pallet for the B and T cells.