May I please ask a question? Someone has asked me to explain this to them - they have pointed out that the paper said there was no change in IgG4 on Figure 4. I am a layperson, but this is what I told them I thought was the gist of your article. Apologies if I got it wrong, and I would be so grateful for a correction. Cheers, Anna
"I think C and D show aggregate data, whereas Mowrey is interested in the outliers in the individual data points shown in A and B. The aberrant individuals are not enough to change the overall finding of no effect. As reported in the paper, IgG4 was not significantly enhanced overall in vaccinated mothers. Mowrey points out that there are outliers with high IgG4 present in the vaccinated group for both cord and maternal RBD (IgG2 looks like it has outliers too?). These outliers were too few to lead to an overall significant difference, however he suggests that this is because conversion to a high IgG4 ratio takes time to develop (refs: here, here, and here), and that the outliers were likely those who were vaccinated earliest. His concern is that, given time, the others would also see a raised IgG4 ratio."
I have a personal experience with tranfection just from exosomes or such, proximity. That was the last night I slept next to my (ex) partner. So, I have no doubt this was designed to pass through multiple vectors. Babies, adults, zoo animals, they care not 'what' they kill, we are not even a 'who' to them. 'Our' military is killing us freely now. I only have one way to withdraw my support, ie the yearly tithe. Part of me hopes that the death of the dollar, if it happens fast enough, will take this horrid machine down, at least, along with many of the rest of us. I don't see much of another way to starve 'the glob' (all the baddies together) but to remove their salaries quite suddenly before the digimoney can take hold. I don't think we can do it 'from within' the existing systems.
I've personally considered that a lot of this IgG4 may be related to a risk of autoantibody formation. I've been meaning to write a full series on autoimmunity but have held off. I'm curious if this is suggestive of the body attempting to prevent the targeting of its own cells due to activation of auto T-cells and autoantibodies. Of course, this hypothesis would be rather testable relative to other ones. One could isolate the IgG4 antibodies and test them for binding to human tissues/cells. One could also correlate vaccine adverse reactions with IgG4 levels and that may provide some insight as well.
I think this partially explains why multiple doses are needed, and for those who need fewer it's possible that reactivation of autoantibodies are occurring as was possibly seen in one case report of encephalitis in an individual.
I'm considering if the vaccination course should be considered biphasic, in which naiive people may have to be looked at from the perspective of spike cytotoxicity but after the adaptive immune system takes hold that a move towards autoimmunity should be examined.
This whole IG4 issue seems irrelevant. Everybody around here is triple mRNA injected and Covid is not an issue any more. I am fine, my wife is fine, our friends seem healthy, I haven't heard about nasty repeat infections.
So, I'm thinking there may be a mitigating factor here, which would reduce the likelihood of IgG4 antibodies being passed on to a new born.
If I'm understanding things correctly, a vaccinated mother won't necessarily (and/or always) have IgG4 antibodies circulating in her system when she is pregnant. Eventually, spike antigen IgG4 antibodies should wane in time (right?). And, the only time they would show up again is after a covid-variant infection (one which gets past the innate arm immune system and lasts longer than 7 days, prompting the adaptive arm to kick in) or a subsequent jab. Consequently, an expectant mother would only be able to pass on IgG4 antibodies to her baby if she, within a certain window of time relative to her pregnancy: 1) got a subsequent jab; or 2) got Covid.
It seems to me then that: 1) not many people are gung ho about getting a 4th, 5th, or 6th jab; and 2) not many people are getting Covid anymore. Thus, I would think (and hope) that we should not have an issue with newborns and IgG4 tolerance. Now, if this deadly variant that GVB has been prophesying comes to pass.....well then, that could be a problem.
May 4, 2023·edited May 4, 2023Liked by Brian Mowrey
Well, I guess one of the messages for pregnant vaccinated mothers and the vaccinated in general is:
Don't go near hospitals or health-care workers because they are more likely to harbor SARS-CoV-2.
Expanding on that, since health-care staff have all been vaccinated with the mRNA gene therapy and boosted to the hilt, they likely have all switched to producing IgG4 for the SARS-CoV-2 S-protein.
Thus they are highly likely to be carrying the virus.
Is it worse than I thought?
https://jessicar.substack.com/p/igg4-antibodies-induced-by-repeated
Is it possible that because of Fc-Fc binding, IgG4 antibodies actually neutralize all other IgG1 antibodies?
Does this matter if the mRNA gene therapy pushes them to predominantly IgG4 antibody creation?
https://www.pnas.org/doi/10.1073/pnas.2107249118
Almost all you need to know about IgG4 antibodies:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123589/
May I please ask a question? Someone has asked me to explain this to them - they have pointed out that the paper said there was no change in IgG4 on Figure 4. I am a layperson, but this is what I told them I thought was the gist of your article. Apologies if I got it wrong, and I would be so grateful for a correction. Cheers, Anna
"I think C and D show aggregate data, whereas Mowrey is interested in the outliers in the individual data points shown in A and B. The aberrant individuals are not enough to change the overall finding of no effect. As reported in the paper, IgG4 was not significantly enhanced overall in vaccinated mothers. Mowrey points out that there are outliers with high IgG4 present in the vaccinated group for both cord and maternal RBD (IgG2 looks like it has outliers too?). These outliers were too few to lead to an overall significant difference, however he suggests that this is because conversion to a high IgG4 ratio takes time to develop (refs: here, here, and here), and that the outliers were likely those who were vaccinated earliest. His concern is that, given time, the others would also see a raised IgG4 ratio."
I have a personal experience with tranfection just from exosomes or such, proximity. That was the last night I slept next to my (ex) partner. So, I have no doubt this was designed to pass through multiple vectors. Babies, adults, zoo animals, they care not 'what' they kill, we are not even a 'who' to them. 'Our' military is killing us freely now. I only have one way to withdraw my support, ie the yearly tithe. Part of me hopes that the death of the dollar, if it happens fast enough, will take this horrid machine down, at least, along with many of the rest of us. I don't see much of another way to starve 'the glob' (all the baddies together) but to remove their salaries quite suddenly before the digimoney can take hold. I don't think we can do it 'from within' the existing systems.
"If there is a direct risk, however, it will presumably only apply for as long as maternal antibodies persist in infants, which is only a few months."
No issues with breast milk passing on similarly ill-conceived maternal antibodies then?
On another topic: https://medicalxpress.com/news/2023-05-covid-patients-wasnt-cytokine-storm.html
You may have seen it, but:
"What really killed COVID-19 patients: It wasn't a cytokine storm, suggests study"
I've personally considered that a lot of this IgG4 may be related to a risk of autoantibody formation. I've been meaning to write a full series on autoimmunity but have held off. I'm curious if this is suggestive of the body attempting to prevent the targeting of its own cells due to activation of auto T-cells and autoantibodies. Of course, this hypothesis would be rather testable relative to other ones. One could isolate the IgG4 antibodies and test them for binding to human tissues/cells. One could also correlate vaccine adverse reactions with IgG4 levels and that may provide some insight as well.
I think this partially explains why multiple doses are needed, and for those who need fewer it's possible that reactivation of autoantibodies are occurring as was possibly seen in one case report of encephalitis in an individual.
I'm considering if the vaccination course should be considered biphasic, in which naiive people may have to be looked at from the perspective of spike cytotoxicity but after the adaptive immune system takes hold that a move towards autoimmunity should be examined.
This whole IG4 issue seems irrelevant. Everybody around here is triple mRNA injected and Covid is not an issue any more. I am fine, my wife is fine, our friends seem healthy, I haven't heard about nasty repeat infections.
So, I'm thinking there may be a mitigating factor here, which would reduce the likelihood of IgG4 antibodies being passed on to a new born.
If I'm understanding things correctly, a vaccinated mother won't necessarily (and/or always) have IgG4 antibodies circulating in her system when she is pregnant. Eventually, spike antigen IgG4 antibodies should wane in time (right?). And, the only time they would show up again is after a covid-variant infection (one which gets past the innate arm immune system and lasts longer than 7 days, prompting the adaptive arm to kick in) or a subsequent jab. Consequently, an expectant mother would only be able to pass on IgG4 antibodies to her baby if she, within a certain window of time relative to her pregnancy: 1) got a subsequent jab; or 2) got Covid.
It seems to me then that: 1) not many people are gung ho about getting a 4th, 5th, or 6th jab; and 2) not many people are getting Covid anymore. Thus, I would think (and hope) that we should not have an issue with newborns and IgG4 tolerance. Now, if this deadly variant that GVB has been prophesying comes to pass.....well then, that could be a problem.
Well, I guess one of the messages for pregnant vaccinated mothers and the vaccinated in general is:
Don't go near hospitals or health-care workers because they are more likely to harbor SARS-CoV-2.
Expanding on that, since health-care staff have all been vaccinated with the mRNA gene therapy and boosted to the hilt, they likely have all switched to producing IgG4 for the SARS-CoV-2 S-protein.
Thus they are highly likely to be carrying the virus.
.
Leading Cause Of Death In U.S.
Medical School
.
Thank you for staying on top of the IgG4 learnings Brian. Two words: Unintended consequences.
Here's more new coverage, albeit general;
https://www.nature.com/articles/s41577-023-00871-z
Review Article
Published: 24 April 2023
The unique properties of IgG4 and its roles in health and disease
I speculated to myself that that might happen. Sad to see it confirmed.
Thanks for fleshing that out. Much appreciated. Bummer on the reality
IgG4 against bovine folate receptor alpha (FRA) crosses the placenta to cause autism in the fetus.
https://www.bmj.com/content/361/bmj.k1674/rr-2
https://vinuarumugham.substack.com/p/cows-milk-protein-contaminated-vaccines