May I please ask a question? Someone has asked me to explain this to them - they have pointed out that the paper said there was no change in IgG4 on Figure 4. I am a layperson, but this is what I told them I thought was the gist of your article. Apologies if I got it wrong, and I would be so grateful for a correction. Cheers, Anna
"I think C and D show aggregate data, whereas Mowrey is interested in the outliers in the individual data points shown in A and B. The aberrant individuals are not enough to change the overall finding of no effect. As reported in the paper, IgG4 was not significantly enhanced overall in vaccinated mothers. Mowrey points out that there are outliers with high IgG4 present in the vaccinated group for both cord and maternal RBD (IgG2 looks like it has outliers too?). These outliers were too few to lead to an overall significant difference, however he suggests that this is because conversion to a high IgG4 ratio takes time to develop (refs: here, here, and here), and that the outliers were likely those who were vaccinated earliest. His concern is that, given time, the others would also see a raised IgG4 ratio."
The study wasn’t designed for detecting long term kinetics, and so it is showing recently injected and less recently injected together, with a clear skew toward the former per the trimester / number of doses pie in supplemental figure one, which is why I include that in my presentation of the IgG4 levels.
Also, in general, you can see that the vaccinated mothers are very bipolar on all four IgG types, with low clusters and high clusters, and so the mathematically derived bars are losing a lot of resolution. They just happen to land slightly-higher than the natural infection bars but that isn't describing what is happening for IgG1, IgG2, IgG3 with the vaccinated, all of these are off the chart compared to natural infection. IgG4 is the same. Too much antigen, too much antibodies.
We have three separate studies now (footnotes 4 - 6) showing that IgG4 emerges after several months, detected after breakthrough infection or booster but potentially already there for all double-dose recipients after those months go by (if it were to be looked for).
So we can infer that the IgG4 outliers are ones dosed earlier in pregnancy, and/or receiving booster before delivery, delivering toward end of study window. We don’t care that the IgG4 goes away when these are lumped in with earlier deliveries from 2021 because we don’t have a time machine. 2021 is over. IgG4 is the future.
I'll say that twice, for emphasis. The disappearance of the IgG4 trend when all sampled pregnancies are lumped together, with most being recently-injected and back in 2021, is to-be-expected, and uninteresting. It doesn't inform what's been happening since 2022 or what will happen with today's young girls as they become adults. It's over.
Thank you so much! That’s everything I wanted to say, but lacked the knowledge to put into words. Also - every day I find another reason to be happy that I never let my little girl get jabbed. Im worried about all my friend’s kids. Thank you Brian.
I have a personal experience with tranfection just from exosomes or such, proximity. That was the last night I slept next to my (ex) partner. So, I have no doubt this was designed to pass through multiple vectors. Babies, adults, zoo animals, they care not 'what' they kill, we are not even a 'who' to them. 'Our' military is killing us freely now. I only have one way to withdraw my support, ie the yearly tithe. Part of me hopes that the death of the dollar, if it happens fast enough, will take this horrid machine down, at least, along with many of the rest of us. I don't see much of another way to starve 'the glob' (all the baddies together) but to remove their salaries quite suddenly before the digimoney can take hold. I don't think we can do it 'from within' the existing systems.
oh I am bummed to hear this Nancy, doesn't it make it hard to pay much attention to all the docs insisting its about spike proteins .....i think its likely a huge distraction to keep people mucking about in the wrong direction...i am thankful that at least a few folks seem to be actually looking at the blood, and very few actually do. So much 'knowledge' is just parroted without proofs, expensive educations are a type of pharma programming that is hard for folks to break up with...this is an energy weapon, and it takes so little voltage to mess with people once we are transfected. Blood thinning foods and plants like birch and witch hazel (homemade version of it can be ingested) and they both do that...i know there are alot of parentless kids out there now, so i suppose some of them may come under my care in the future, as i teach some, though i am not so interested in adoption due to my age and means. Dogs and cats too will need homes after owners die. That is probably something i could do to help. Geez.
In that case it should still only be active in the GI tract, and not absorb much or at all. Hence why there's no persistence of birth-level circulatory IgG after a few months, and why IgA is presumed to have a bigger role as far as breastmilk (since IgA will still be active in the gut).
This is what I would expect and I cannot see any reason why FcRn (Neonatal Fc Receptors) would not transport IgG4 antibodies across the gut into the body. Especially since they can do so with the syncytiotrophoblast. Does the mother not package FcRn in her milk as well?
However, maybe further research will provide a mechanism for why it does not occur.
Well now I'm just confused about IgG and breastmilk. In all accounts mere months is when maternal IgG is no longer expected to be around in human infants, in some cases 100% of infants lose serum neutralization levels of antibodies at just two months (e.g. classic Shope swine flu seroarcheology study in 1936), and the vaccine schedule starts the assault at month 2 because maternal antibodies are no longer expected to interfere (masking antigen).
Yes. So like with ye olden Shope experiment, he's mixing blood from all different ages with swine flu and then seeing if mice get sick. Adults and 1 months olds, the mice don't get sick (virus neutralized). 2 months old up to adults (there was no more matching flu for kids to get infected with anymore), 100% of donors, mice get sick. So the antibodies fade that fast, aren't being maintained in blood.
If there's no flu on baby's face, maybe there's no flu antibodies generated in the milk, none passed to the feeding baby so no mice are protected?
If there's COVID on the baby's face, and Mum picks that up through contact, maybe the COVID antibodies generated and transferred in the milk are Ig4 then and only then?
Regardless, the horror I experience reading these sorts of posts, and others, is that this sort of thing (you would hope / expect) is the exact sort of thing that takes years and years to determine via clinical trial and in-depth thinking and study, before unleashing a new vaccine on the population.
Thanks for the link - still wading my way through all the results. It's not jumping out to me how they reach some of the conclusions, but it's a lot more information on clinical outcomes than was previously published
I've personally considered that a lot of this IgG4 may be related to a risk of autoantibody formation. I've been meaning to write a full series on autoimmunity but have held off. I'm curious if this is suggestive of the body attempting to prevent the targeting of its own cells due to activation of auto T-cells and autoantibodies. Of course, this hypothesis would be rather testable relative to other ones. One could isolate the IgG4 antibodies and test them for binding to human tissues/cells. One could also correlate vaccine adverse reactions with IgG4 levels and that may provide some insight as well.
I think this partially explains why multiple doses are needed, and for those who need fewer it's possible that reactivation of autoantibodies are occurring as was possibly seen in one case report of encephalitis in an individual.
I'm considering if the vaccination course should be considered biphasic, in which naiive people may have to be looked at from the perspective of spike cytotoxicity but after the adaptive immune system takes hold that a move towards autoimmunity should be examined.
Yeah, I increasingly think spike toxicity is moot after you have antibodies and B Cells pre-loaded, otherwise the boosted would be showing more dose-dependent harm patterns.
Why are multiple doses "needed"? One dose is probably fine as far as generating whatever severe efficacy there is.
Which is weird when we consider how much nattokinase is being pushed now, almost 2 years since the start of the vaccination and more than a year after boosting.
I've held the same perspective as you as in, "probably wouldn't hurt," but now there are protocols involving nattokinase as a spike detoxifier...now? I think a lot of this is conflating key issues with the vaccines. The spike effect is plausible for the first exposure but afterwards that probably shouldn't explain the adverse reactions seen if spike should be bound.
But if we were to argue the issue with doses, I'd argue that the issue happened right from the start when it was argued that a gap of two week should be done between the two doses. I think that likely had a big effect on the course of events.
This whole IG4 issue seems irrelevant. Everybody around here is triple mRNA injected and Covid is not an issue any more. I am fine, my wife is fine, our friends seem healthy, I haven't heard about nasty repeat infections.
What I'm seeing around me is that the ultra vaxxed are thinking that everything is just fine and will stay fine, no matter what happens to people they know, and no matter how terrible they look (and they do look awful). They dismiss actual incidents of illness as being irrelevant. Maybe that is due to a cognitive effect of the vax or covid itself or a combo. There really seems to be a zombie effect. It is funny that you can have such high excess mortality without people noticing it on the ground. It is like a flock of birds with the occasional bird being picked off by a predator; the flock members tweet for a minute or two and then go on as ever. The long term doesn't exist for them. In the meantime, people keep retiring from their jobs; people who in the past would have worked til they were in their 80s, but now they are just so tired. But the young people are the most tired of all.
I was talking to someone whose intelligence I respect, who is also pro-vax, and when I asked (re: safe and effective), "so what's causing all the excess deaths?" they had no idea what I was talking about.
I'm not saying that you personally are wrong in what you are personally seeing. But mice who are infected with toxoplasmosis lose their fear of the smell of cat urine. And I don't think that they are consciously aware of that. People who are demented often don't know that they are demented. People who are infected with flu, become more sociable without being aware of that. I don't think the subjects of this study were (or are?) aware of how their brains have changed: https://www.brainfacts.org/diseases-and-disorders/covid-19/2023/the-risks-of-even-mild-covid19-1-in-4-showing-cognitive-deficits-011723#.ZDNC_dg2T9o.twitter.
I'm not vaccinated, and it seems that I haven't caught covid (I test weekly as required for my volunteer position, and I use various preventatives). I would bet that I'm seeing things differently from the way that vaccinated or infected people do. Of course, it could be that vaccinated/infected people are seeing things correctly, and I am not. That is why things like excess mortality data are useful.
Same here in SoCal. It's all a question about long term. Damning up a river doesn't seem to be a big deal on days 1 to 1000. This doesn't brook any consequences that come later.
Why would it matter in the long term? The IgG4 conversion has already happened and resulted in nothing obviously bad. As the Virus keeps mutating, the effects will likely wane over the Long Run....
The same reason it matters long term whether you keep up your garden. If the virus is a weed that wants to infiltrate, sure it's great that you fought it off yesterday, but you have to keep that up for the rest of your life.
With all viruses, we implicitly rely on functioning memory immunity to stay alive, otherwise, why would evolution have even bothered creating it - as a photo album? So the question is what happens if that immunity turns to tolerance. The closest parallels are disease-associated persistent infections like EBV or hepatitis viruses, where when the initial immune response doesn't fend the virus off, tolerance starts to kick in and the body is essentially just riding out the infection until organs give out. Is that what we will start to see with kids vaccinated last year who get reinfected one random day in their teens, who knows... But that's the long term obstacle course the host and virus are now going down. Decades of IgG4 that never goes away.
So, I'm thinking there may be a mitigating factor here, which would reduce the likelihood of IgG4 antibodies being passed on to a new born.
If I'm understanding things correctly, a vaccinated mother won't necessarily (and/or always) have IgG4 antibodies circulating in her system when she is pregnant. Eventually, spike antigen IgG4 antibodies should wane in time (right?). And, the only time they would show up again is after a covid-variant infection (one which gets past the innate arm immune system and lasts longer than 7 days, prompting the adaptive arm to kick in) or a subsequent jab. Consequently, an expectant mother would only be able to pass on IgG4 antibodies to her baby if she, within a certain window of time relative to her pregnancy: 1) got a subsequent jab; or 2) got Covid.
It seems to me then that: 1) not many people are gung ho about getting a 4th, 5th, or 6th jab; and 2) not many people are getting Covid anymore. Thus, I would think (and hope) that we should not have an issue with newborns and IgG4 tolerance. Now, if this deadly variant that GVB has been prophesying comes to pass.....well then, that could be a problem.
The "baseline" for respiratory viral IgG antibodies might not be as stratospheric as immediately after an mRNA booster, but it is still substantial. The evergreen exemplar here being influenza A, where donor blood is permanently "sinned" with strong antibodies against prevalent strains encountered in (both) childhood (and afterward). Post-Covid-mRNA antibodies may be super-high due to mRNA antigen-overload, intrinsic antigen "interesting-ness," or a combination of both, but whatever the case, it seems safe to predict that the inter-booster baseline levels of IgG will be on the high end.
So, in other words, once IgG antibodies are made (of any kind, whether in response to something like a SARS coronavirus infection or vaccine), they will permanently remain present in the blood, albeit at lower levels yet sufficient enough for a mother to pass on to her baby. Is that correct?
It depends on the prompt, i.e. the molecule the immune system is taking interest in. The term "antigen" was a natural choice from the beginning because there is a "something about" this substance that then makes humans or other mammals create antibodies. Different "something abouts" have different levels of "gen." Flu tends to be highly antigenetic. A first encounter results in long-duration germinal center responses in animals in the lab. Elderly adults in 1957 and 1968 turned out to already have high levels of H2 and H3 flu antibodies leftover from pre-1918 strains.
This could simply be a reflection of how much antigen load results from infection, so it's not actually about the spike protein but about the virulence of the virus that makes it. Well, in that case, mRNA transfection and spike antigen overload are a recipe for trouble. More spike everywhere in the body means more germinal centers recruited to generate immune response, more B Cells, *and* more long lived plasma cells that go live in bone marrow forever to keep pumping out baseline antibodies.
Well, I guess one of the messages for pregnant vaccinated mothers and the vaccinated in general is:
Don't go near hospitals or health-care workers because they are more likely to harbor SARS-CoV-2.
Expanding on that, since health-care staff have all been vaccinated with the mRNA gene therapy and boosted to the hilt, they likely have all switched to producing IgG4 for the SARS-CoV-2 S-protein.
Thus they are highly likely to be carrying the virus.
That article is rather interesting. I glossed over it a bit but it appears to suggest that class conversion to IgG4 isn't occurring with IgG1 in a high degree (in vivo supposedly), but larger proportion of class switching is occurring from IgM -> IgG4. That would be something worth investigating if true.
Yes, the article seems to be the work of some truly inquisitive scientists, and not some kind of apologetic for the transfections. Here they discuss why it might be that injecting relatively small, or single antigen proteins vs whole virus might be a problem;
"IgG4 is not commonly part of the antibody response to bacterial or viral infection. The range of situations in which specific IgG4 is or can be a dominant factor is wide and includes responses to allergens, therapeutically administered proteins, autoantigens and helminth infections. With the exception of helminths, the absence of an infectious agent seems to be a common feature of IgG4 responses and it is tempting to speculate that the absence of certain danger signals such as pathogen-associated molecular patterns (PAMPs) is a prerequisite for B cells to differentiate towards IgG4-secreting cells in vivo. Indeed, the proportion of IgG4 antibodies was smaller in individuals receiving whole-cell pertussis vaccine than in individuals receiving acellular pertussis vaccine (although IgG4 was only a small fraction of the total IgG response even in the latter)16."
Is it worse than I thought?
https://jessicar.substack.com/p/igg4-antibodies-induced-by-repeated
Is it possible that because of Fc-Fc binding, IgG4 antibodies actually neutralize all other IgG1 antibodies?
Does this matter if the mRNA gene therapy pushes them to predominantly IgG4 antibody creation?
https://www.pnas.org/doi/10.1073/pnas.2107249118
Almost all you need to know about IgG4 antibodies:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123589/
May I please ask a question? Someone has asked me to explain this to them - they have pointed out that the paper said there was no change in IgG4 on Figure 4. I am a layperson, but this is what I told them I thought was the gist of your article. Apologies if I got it wrong, and I would be so grateful for a correction. Cheers, Anna
"I think C and D show aggregate data, whereas Mowrey is interested in the outliers in the individual data points shown in A and B. The aberrant individuals are not enough to change the overall finding of no effect. As reported in the paper, IgG4 was not significantly enhanced overall in vaccinated mothers. Mowrey points out that there are outliers with high IgG4 present in the vaccinated group for both cord and maternal RBD (IgG2 looks like it has outliers too?). These outliers were too few to lead to an overall significant difference, however he suggests that this is because conversion to a high IgG4 ratio takes time to develop (refs: here, here, and here), and that the outliers were likely those who were vaccinated earliest. His concern is that, given time, the others would also see a raised IgG4 ratio."
The study wasn’t designed for detecting long term kinetics, and so it is showing recently injected and less recently injected together, with a clear skew toward the former per the trimester / number of doses pie in supplemental figure one, which is why I include that in my presentation of the IgG4 levels.
Also, in general, you can see that the vaccinated mothers are very bipolar on all four IgG types, with low clusters and high clusters, and so the mathematically derived bars are losing a lot of resolution. They just happen to land slightly-higher than the natural infection bars but that isn't describing what is happening for IgG1, IgG2, IgG3 with the vaccinated, all of these are off the chart compared to natural infection. IgG4 is the same. Too much antigen, too much antibodies.
We have three separate studies now (footnotes 4 - 6) showing that IgG4 emerges after several months, detected after breakthrough infection or booster but potentially already there for all double-dose recipients after those months go by (if it were to be looked for).
So we can infer that the IgG4 outliers are ones dosed earlier in pregnancy, and/or receiving booster before delivery, delivering toward end of study window. We don’t care that the IgG4 goes away when these are lumped in with earlier deliveries from 2021 because we don’t have a time machine. 2021 is over. IgG4 is the future.
I'll say that twice, for emphasis. The disappearance of the IgG4 trend when all sampled pregnancies are lumped together, with most being recently-injected and back in 2021, is to-be-expected, and uninteresting. It doesn't inform what's been happening since 2022 or what will happen with today's young girls as they become adults. It's over.
Thank you so much! That’s everything I wanted to say, but lacked the knowledge to put into words. Also - every day I find another reason to be happy that I never let my little girl get jabbed. Im worried about all my friend’s kids. Thank you Brian.
I have a personal experience with tranfection just from exosomes or such, proximity. That was the last night I slept next to my (ex) partner. So, I have no doubt this was designed to pass through multiple vectors. Babies, adults, zoo animals, they care not 'what' they kill, we are not even a 'who' to them. 'Our' military is killing us freely now. I only have one way to withdraw my support, ie the yearly tithe. Part of me hopes that the death of the dollar, if it happens fast enough, will take this horrid machine down, at least, along with many of the rest of us. I don't see much of another way to starve 'the glob' (all the baddies together) but to remove their salaries quite suddenly before the digimoney can take hold. I don't think we can do it 'from within' the existing systems.
I broke up with my ex not that long after he got his primary series. Stopped getting periods soon after that, and now in menopause.
oh I am bummed to hear this Nancy, doesn't it make it hard to pay much attention to all the docs insisting its about spike proteins .....i think its likely a huge distraction to keep people mucking about in the wrong direction...i am thankful that at least a few folks seem to be actually looking at the blood, and very few actually do. So much 'knowledge' is just parroted without proofs, expensive educations are a type of pharma programming that is hard for folks to break up with...this is an energy weapon, and it takes so little voltage to mess with people once we are transfected. Blood thinning foods and plants like birch and witch hazel (homemade version of it can be ingested) and they both do that...i know there are alot of parentless kids out there now, so i suppose some of them may come under my care in the future, as i teach some, though i am not so interested in adoption due to my age and means. Dogs and cats too will need homes after owners die. That is probably something i could do to help. Geez.
Luckily I had a son before this happened. He’s three now.
"If there is a direct risk, however, it will presumably only apply for as long as maternal antibodies persist in infants, which is only a few months."
No issues with breast milk passing on similarly ill-conceived maternal antibodies then?
In that case it should still only be active in the GI tract, and not absorb much or at all. Hence why there's no persistence of birth-level circulatory IgG after a few months, and why IgA is presumed to have a bigger role as far as breastmilk (since IgA will still be active in the gut).
Quick search appears to say yes, IgG4 is coming through breast milk as well:
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1651-2227.1988.tb10592.x
https://journals.aai.org/jimmunol/article-abstract/130/4/1654/41048/Local-production-of-IgG4-in-human-colostrum
This is what I would expect and I cannot see any reason why FcRn (Neonatal Fc Receptors) would not transport IgG4 antibodies across the gut into the body. Especially since they can do so with the syncytiotrophoblast. Does the mother not package FcRn in her milk as well?
However, maybe further research will provide a mechanism for why it does not occur.
Well now I'm just confused about IgG and breastmilk. In all accounts mere months is when maternal IgG is no longer expected to be around in human infants, in some cases 100% of infants lose serum neutralization levels of antibodies at just two months (e.g. classic Shope swine flu seroarcheology study in 1936), and the vaccine schedule starts the assault at month 2 because maternal antibodies are no longer expected to interfere (masking antigen).
How are they measuring the presence of IgG? With a blood draw from infants?
Yes. So like with ye olden Shope experiment, he's mixing blood from all different ages with swine flu and then seeing if mice get sick. Adults and 1 months olds, the mice don't get sick (virus neutralized). 2 months old up to adults (there was no more matching flu for kids to get infected with anymore), 100% of donors, mice get sick. So the antibodies fade that fast, aren't being maintained in blood.
If there's no flu on baby's face, maybe there's no flu antibodies generated in the milk, none passed to the feeding baby so no mice are protected?
If there's COVID on the baby's face, and Mum picks that up through contact, maybe the COVID antibodies generated and transferred in the milk are Ig4 then and only then?
Sounds like a crapshoot.
Regardless, the horror I experience reading these sorts of posts, and others, is that this sort of thing (you would hope / expect) is the exact sort of thing that takes years and years to determine via clinical trial and in-depth thinking and study, before unleashing a new vaccine on the population.
Safe and effective!
eg: https://www.baby-chick.com/how-kissing-your-baby-changes-your-breastmilk/
And here I naively thought breast feeding was awesome for the ongoing antibody feeding.
1. Mum kisses the babies face,
2. picks up bugs from that kiss,
3. generates antibodies, then
4. passes them to baby via breast milk.
But not IgG?
On another topic: https://medicalxpress.com/news/2023-05-covid-patients-wasnt-cytokine-storm.html
You may have seen it, but:
"What really killed COVID-19 patients: It wasn't a cytokine storm, suggests study"
Thanks for the link - still wading my way through all the results. It's not jumping out to me how they reach some of the conclusions, but it's a lot more information on clinical outcomes than was previously published
He has written on this: https://unglossed.substack.com/p/tolerance-and-severe-disease-pt-1#%C2%A7the-myth-of-cytokine-storm
Yeah, that was my point. Support for what Brian has been saying.
I've personally considered that a lot of this IgG4 may be related to a risk of autoantibody formation. I've been meaning to write a full series on autoimmunity but have held off. I'm curious if this is suggestive of the body attempting to prevent the targeting of its own cells due to activation of auto T-cells and autoantibodies. Of course, this hypothesis would be rather testable relative to other ones. One could isolate the IgG4 antibodies and test them for binding to human tissues/cells. One could also correlate vaccine adverse reactions with IgG4 levels and that may provide some insight as well.
I think this partially explains why multiple doses are needed, and for those who need fewer it's possible that reactivation of autoantibodies are occurring as was possibly seen in one case report of encephalitis in an individual.
I'm considering if the vaccination course should be considered biphasic, in which naiive people may have to be looked at from the perspective of spike cytotoxicity but after the adaptive immune system takes hold that a move towards autoimmunity should be examined.
Yeah, I increasingly think spike toxicity is moot after you have antibodies and B Cells pre-loaded, otherwise the boosted would be showing more dose-dependent harm patterns.
Why are multiple doses "needed"? One dose is probably fine as far as generating whatever severe efficacy there is.
Which is weird when we consider how much nattokinase is being pushed now, almost 2 years since the start of the vaccination and more than a year after boosting.
I've held the same perspective as you as in, "probably wouldn't hurt," but now there are protocols involving nattokinase as a spike detoxifier...now? I think a lot of this is conflating key issues with the vaccines. The spike effect is plausible for the first exposure but afterwards that probably shouldn't explain the adverse reactions seen if spike should be bound.
But if we were to argue the issue with doses, I'd argue that the issue happened right from the start when it was argued that a gap of two week should be done between the two doses. I think that likely had a big effect on the course of events.
This whole IG4 issue seems irrelevant. Everybody around here is triple mRNA injected and Covid is not an issue any more. I am fine, my wife is fine, our friends seem healthy, I haven't heard about nasty repeat infections.
What I'm seeing around me is that the ultra vaxxed are thinking that everything is just fine and will stay fine, no matter what happens to people they know, and no matter how terrible they look (and they do look awful). They dismiss actual incidents of illness as being irrelevant. Maybe that is due to a cognitive effect of the vax or covid itself or a combo. There really seems to be a zombie effect. It is funny that you can have such high excess mortality without people noticing it on the ground. It is like a flock of birds with the occasional bird being picked off by a predator; the flock members tweet for a minute or two and then go on as ever. The long term doesn't exist for them. In the meantime, people keep retiring from their jobs; people who in the past would have worked til they were in their 80s, but now they are just so tired. But the young people are the most tired of all.
I was talking to someone whose intelligence I respect, who is also pro-vax, and when I asked (re: safe and effective), "so what's causing all the excess deaths?" they had no idea what I was talking about.
If it's not on the news it's not on their minds.
All that I can say is that I have the same health issues that I had before getting jabbed.
Nobody that I know closely died, nobody aged prematurely, I don't see more illness than before.
I'm not saying that you personally are wrong in what you are personally seeing. But mice who are infected with toxoplasmosis lose their fear of the smell of cat urine. And I don't think that they are consciously aware of that. People who are demented often don't know that they are demented. People who are infected with flu, become more sociable without being aware of that. I don't think the subjects of this study were (or are?) aware of how their brains have changed: https://www.brainfacts.org/diseases-and-disorders/covid-19/2023/the-risks-of-even-mild-covid19-1-in-4-showing-cognitive-deficits-011723#.ZDNC_dg2T9o.twitter.
I'm not vaccinated, and it seems that I haven't caught covid (I test weekly as required for my volunteer position, and I use various preventatives). I would bet that I'm seeing things differently from the way that vaccinated or infected people do. Of course, it could be that vaccinated/infected people are seeing things correctly, and I am not. That is why things like excess mortality data are useful.
Same here in SoCal. It's all a question about long term. Damning up a river doesn't seem to be a big deal on days 1 to 1000. This doesn't brook any consequences that come later.
Why would it matter in the long term? The IgG4 conversion has already happened and resulted in nothing obviously bad. As the Virus keeps mutating, the effects will likely wane over the Long Run....
The same reason it matters long term whether you keep up your garden. If the virus is a weed that wants to infiltrate, sure it's great that you fought it off yesterday, but you have to keep that up for the rest of your life.
With all viruses, we implicitly rely on functioning memory immunity to stay alive, otherwise, why would evolution have even bothered creating it - as a photo album? So the question is what happens if that immunity turns to tolerance. The closest parallels are disease-associated persistent infections like EBV or hepatitis viruses, where when the initial immune response doesn't fend the virus off, tolerance starts to kick in and the body is essentially just riding out the infection until organs give out. Is that what we will start to see with kids vaccinated last year who get reinfected one random day in their teens, who knows... But that's the long term obstacle course the host and virus are now going down. Decades of IgG4 that never goes away.
So, I'm thinking there may be a mitigating factor here, which would reduce the likelihood of IgG4 antibodies being passed on to a new born.
If I'm understanding things correctly, a vaccinated mother won't necessarily (and/or always) have IgG4 antibodies circulating in her system when she is pregnant. Eventually, spike antigen IgG4 antibodies should wane in time (right?). And, the only time they would show up again is after a covid-variant infection (one which gets past the innate arm immune system and lasts longer than 7 days, prompting the adaptive arm to kick in) or a subsequent jab. Consequently, an expectant mother would only be able to pass on IgG4 antibodies to her baby if she, within a certain window of time relative to her pregnancy: 1) got a subsequent jab; or 2) got Covid.
It seems to me then that: 1) not many people are gung ho about getting a 4th, 5th, or 6th jab; and 2) not many people are getting Covid anymore. Thus, I would think (and hope) that we should not have an issue with newborns and IgG4 tolerance. Now, if this deadly variant that GVB has been prophesying comes to pass.....well then, that could be a problem.
The "baseline" for respiratory viral IgG antibodies might not be as stratospheric as immediately after an mRNA booster, but it is still substantial. The evergreen exemplar here being influenza A, where donor blood is permanently "sinned" with strong antibodies against prevalent strains encountered in (both) childhood (and afterward). Post-Covid-mRNA antibodies may be super-high due to mRNA antigen-overload, intrinsic antigen "interesting-ness," or a combination of both, but whatever the case, it seems safe to predict that the inter-booster baseline levels of IgG will be on the high end.
So, in other words, once IgG antibodies are made (of any kind, whether in response to something like a SARS coronavirus infection or vaccine), they will permanently remain present in the blood, albeit at lower levels yet sufficient enough for a mother to pass on to her baby. Is that correct?
It depends on the prompt, i.e. the molecule the immune system is taking interest in. The term "antigen" was a natural choice from the beginning because there is a "something about" this substance that then makes humans or other mammals create antibodies. Different "something abouts" have different levels of "gen." Flu tends to be highly antigenetic. A first encounter results in long-duration germinal center responses in animals in the lab. Elderly adults in 1957 and 1968 turned out to already have high levels of H2 and H3 flu antibodies leftover from pre-1918 strains.
This could simply be a reflection of how much antigen load results from infection, so it's not actually about the spike protein but about the virulence of the virus that makes it. Well, in that case, mRNA transfection and spike antigen overload are a recipe for trouble. More spike everywhere in the body means more germinal centers recruited to generate immune response, more B Cells, *and* more long lived plasma cells that go live in bone marrow forever to keep pumping out baseline antibodies.
Makes sense. Thanks for the explanation.
Well, I guess one of the messages for pregnant vaccinated mothers and the vaccinated in general is:
Don't go near hospitals or health-care workers because they are more likely to harbor SARS-CoV-2.
Expanding on that, since health-care staff have all been vaccinated with the mRNA gene therapy and boosted to the hilt, they likely have all switched to producing IgG4 for the SARS-CoV-2 S-protein.
Thus they are highly likely to be carrying the virus.
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Leading Cause Of Death In U.S.
Medical School
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Thank you for staying on top of the IgG4 learnings Brian. Two words: Unintended consequences.
Here's more new coverage, albeit general;
https://www.nature.com/articles/s41577-023-00871-z
Review Article
Published: 24 April 2023
The unique properties of IgG4 and its roles in health and disease
That article is rather interesting. I glossed over it a bit but it appears to suggest that class conversion to IgG4 isn't occurring with IgG1 in a high degree (in vivo supposedly), but larger proportion of class switching is occurring from IgM -> IgG4. That would be something worth investigating if true.
Yes, the article seems to be the work of some truly inquisitive scientists, and not some kind of apologetic for the transfections. Here they discuss why it might be that injecting relatively small, or single antigen proteins vs whole virus might be a problem;
"IgG4 is not commonly part of the antibody response to bacterial or viral infection. The range of situations in which specific IgG4 is or can be a dominant factor is wide and includes responses to allergens, therapeutically administered proteins, autoantigens and helminth infections. With the exception of helminths, the absence of an infectious agent seems to be a common feature of IgG4 responses and it is tempting to speculate that the absence of certain danger signals such as pathogen-associated molecular patterns (PAMPs) is a prerequisite for B cells to differentiate towards IgG4-secreting cells in vivo. Indeed, the proportion of IgG4 antibodies was smaller in individuals receiving whole-cell pertussis vaccine than in individuals receiving acellular pertussis vaccine (although IgG4 was only a small fraction of the total IgG response even in the latter)16."
I speculated to myself that that might happen. Sad to see it confirmed.
Thanks for fleshing that out. Much appreciated. Bummer on the reality
IgG4 against bovine folate receptor alpha (FRA) crosses the placenta to cause autism in the fetus.
https://www.bmj.com/content/361/bmj.k1674/rr-2
https://vinuarumugham.substack.com/p/cows-milk-protein-contaminated-vaccines