"Crackpot" only applies if you're wrong. If you're right, the proper term is "genius." Excellent analysis -- thanks.
The most interesting thing from these revelations is the reminder that research is continuing, and the many mysteries that currently produce the religious fervor will soon be replaced by guidance based on evidence instead of superstition and politics.
Which revelations? I really don't know if the mysteries will ever end. Biology is about 7000 turtles deep into the human cell at this point and the bottom looks further away than ever. Maybe that's for the best - all that's really needed is the acknowledgment that Bacon's legions got pwned by nature in the end, so we should stop worshiping at their alter.
Just getting to the bit where they are discussing lipid nano particles. Seems LNPs may be as much or more of an issue than the spike protein production when it comes to vaccine injuries?
"it has also been found that when the LNPs are transported in the blood then thromboses can occur, or haemolysis – haemolysis means the sudden dissolution of erythrocytes, i.e. red blood cells, this causes hypoxia."
If this ends up being the case, IMO it breaks the vaccine = covid infection injury potential equivalence (I have seen "infection leads to myocarditis too!!"), because there's no LNPs being forced into your mucous membranes with natural infection.
Yes, encountered the link yesterday and still have it in an open tab. I can't believe it's been out since January! I still have to read it. The most interesting part, to me, is the support for the idea that many or most of the early recipients didn't receive functional spike script. This has been my hunch for why the signal for spike script toxicity (which should be universal) has been absent, and the signal for some other, run-of-the-mill chemical toxicity has been stronger.
As an example (as I leave my understanding of biology far behind), this sounds like an avenue for inducing myocarditis to me, and it's all down to the cationic lipids, not the spike protein:
"If however these cationic lipids gain entry, it is confirmed in many publications that they destroy this membrane [Trans: meant is the mitochondrial membrane, here] and this leads to the formation of a large number of oxygen radicals. These oxygen radicals create a lot of damage in the cell. They interact – they alter the amino acids, the cell pours out as many cytokines as it can, the oxygen radicals also attack membranes and create lipid peroxidation. Membrane integrity is jeopardised, the membrane becomes porous, and when a cell membrane becomes porous water flows in and then the ion balance is disrupted. This means the entire cell loses its function because the function of proteins depends on the ion concentration, on the calcium ion for example, and the magnesium ion. The cell experiences maximum oxidative stress, as it is called in the specialist terminology. And when that stress is so high and the DNA is also damaged, then the cell goes into apoptosis – it self-destructs."
"Yes: one is the immune response – via the binding of the antibody. The other factor is that specific component: the cationic lipid. It’s just this component that is so dangerous. It creates maximum oxidative stress in the cell leading to such damage that the cell can’t repair itself fast enough. And that’s why it dies. *** It has to self-destruct, or it transforms into a cancer cell. *** That is the alternative. So it usually self-destructs because if a cancer cell develops, specific damage results, there are other factors involved, but generally it dies."
Still way above my pay grade when it comes to biology. That said, I have a large investment in mitochondria and absolutely no interest in destroying it with a vaccine injection of LNPs.
Wasn’t there a post-1st dose case spike in 90 countries? Among them Mongolia and Vietnam, which had few cases before it but many after? That to me is the Worry Window.
90? I know there were quite a few - but who's to say that would not have happened absent Covid-vaccination? And then there are examples where no such spike occurred - quite notably, in the UK. Or take India - ok, there was a bit of vaccination at the same time as the spring wave - but vaccination continued without the wave. Kerala, of course, is the exception - and so it has become a worry window darling. Well, sure: Go cherry picking, you'll get cherries.
Right, the winter wave turns back up on December 8, the exact day the Covid-vaccine roll-out starts. But then it turns around while the roll-out is still only at 2 million doses. 28 million more first doses and "worry window" entrances between February 10 and end of March, and yet the wave dies out (it's slightly prolonged due to March having the highest testing rates of the entire year).
There are parts that don't seem to fit, so I think there must be more factors at play. One obviously being the prevalence of the virus at the time, another possibly being that healthcare workers, care home staff and vaccinators were among the first being jabbed and were possibly infecting the elderly and infirm whose deaths then formed that January spike.
By the time younger people were being jabbed, the season had changed and they were less likely to come into contact with persons infected. Until summer when we had that strange spike in cases in people of around 40 and younger. Until that point I hadn't known more than one or two people with confirmed covid, but then I started to hear of many cases and nearly all were in recently jabbed. More recently still, my brother-in-law's daughter (15) caught it soon after being jabbed.
So my personal observations tell me that the 'worry window' is likely real, even if there are things we don't understand about it.
Childhood infections in summer 2021 are a tricky one, too - they seem to have increased among all ages, and therefore regardless of vaccine status. Increased susceptibility due to "expressed" spike by older household members, or vaccination, or decay of previously robust innate immunity? Only comparison of "partially vaccinated" infection rates vs unvaccinated per age group can really tell the difference, and I still haven't seen any smoke in that direction.
I think the 'worry window' wouldn't necessarily only affect the vaccinated. If it creates an increase in sick, symptomatic people then the virus would surely spread wider as a result.
Thanks for your reply. Yes, 90 … these did have to do with mass vaccination, not “a bit,” and we know there’s temporary lymphocytemia after the first dose, but certainly it’s hard to pin down all the variables.
That's way more countries than I can even name. I think I need to revisit the original stats one day - If it's a bunch of small hermit countries, that sounds like the virus riding on the shipment and distribution of the shots. Israel was still dosing up young people in July, in the middle of a "breakthrough wave" amongst the older vaccinated. The dashboard didn't show a high rate of "partially vaccinated" infections - it was about half of the unvaccinated per-100k rate. All month long.
Mechanistically, though, it has to be asked "how can SARS-CoV-2 become more contagious than regular coronavirus?" What molecular puzzle can it solve that the ubiquitous common cold hasn't already figured out? No one seems to have an answer. In reality the room for improvement on core replication and transmission competence/efficiency is probably quite low, which means the "super-seasonality" we are seeing is somehow a product of changes to the playing field, not the player. An albino tiger doesn't have to figure out jumping from scratch; it's already perfect at the things that are intrinsic to "tiger" - so Darwin doesn't come into play unless there's a change in climate etc.
Checks out. But I dunno, is SC2 reproductive rate supposed to be higher than common colds? Who's saying that? The seasonal sniffles are pretty transmissible already, IIUC.
Right, which accords with my suggestion that there is competition for "bandwidth." What is unique about SARS-CoV-2 - the tendency to trigger some type of pre-primed inflammatory response, leading to worse outcomes - doesn't overlay with contagiousness. So it's possible that rather than being an "albino tiger," it was an "albino tiger with webbed feed" that needed to fix some fundamentals. But it's also possible that, from a strict perspective of transmission fitness, it is just taking advantage of local differences and changes in "tiger recognition algorithms."
"Crackpot" only applies if you're wrong. If you're right, the proper term is "genius." Excellent analysis -- thanks.
The most interesting thing from these revelations is the reminder that research is continuing, and the many mysteries that currently produce the religious fervor will soon be replaced by guidance based on evidence instead of superstition and politics.
Which revelations? I really don't know if the mysteries will ever end. Biology is about 7000 turtles deep into the human cell at this point and the bottom looks further away than ever. Maybe that's for the best - all that's really needed is the acknowledgment that Bacon's legions got pwned by nature in the end, so we should stop worshiping at their alter.
So do you recommend the jab for any particularly age groups, then?
No. The elderly are probably the most immediately harmed by adverse effects (https://openvaers.com/covid-data/covid-reports/1753024), but their harms are statistically the most obscured via normal high death rates.
Did you see this? http://enformtk.u-aizu.ac.jp/howard/gcep_dr_vanessa_schmidt_krueger/
Interesting read.
Just getting to the bit where they are discussing lipid nano particles. Seems LNPs may be as much or more of an issue than the spike protein production when it comes to vaccine injuries?
"it has also been found that when the LNPs are transported in the blood then thromboses can occur, or haemolysis – haemolysis means the sudden dissolution of erythrocytes, i.e. red blood cells, this causes hypoxia."
If this ends up being the case, IMO it breaks the vaccine = covid infection injury potential equivalence (I have seen "infection leads to myocarditis too!!"), because there's no LNPs being forced into your mucous membranes with natural infection.
Yes, encountered the link yesterday and still have it in an open tab. I can't believe it's been out since January! I still have to read it. The most interesting part, to me, is the support for the idea that many or most of the early recipients didn't receive functional spike script. This has been my hunch for why the signal for spike script toxicity (which should be universal) has been absent, and the signal for some other, run-of-the-mill chemical toxicity has been stronger.
One thing that stood out to me looking at the local AE database was there were no reports until December, despite vaccination starting in July.
"They found evidence of the cationic lipid in the plasma for 12 days"
Is it just me or does that sound like a 2 week worry window?
ok yes you did see it. oops!
As an example (as I leave my understanding of biology far behind), this sounds like an avenue for inducing myocarditis to me, and it's all down to the cationic lipids, not the spike protein:
"If however these cationic lipids gain entry, it is confirmed in many publications that they destroy this membrane [Trans: meant is the mitochondrial membrane, here] and this leads to the formation of a large number of oxygen radicals. These oxygen radicals create a lot of damage in the cell. They interact – they alter the amino acids, the cell pours out as many cytokines as it can, the oxygen radicals also attack membranes and create lipid peroxidation. Membrane integrity is jeopardised, the membrane becomes porous, and when a cell membrane becomes porous water flows in and then the ion balance is disrupted. This means the entire cell loses its function because the function of proteins depends on the ion concentration, on the calcium ion for example, and the magnesium ion. The cell experiences maximum oxidative stress, as it is called in the specialist terminology. And when that stress is so high and the DNA is also damaged, then the cell goes into apoptosis – it self-destructs."
They go on to say re: this process:
"Yes: one is the immune response – via the binding of the antibody. The other factor is that specific component: the cationic lipid. It’s just this component that is so dangerous. It creates maximum oxidative stress in the cell leading to such damage that the cell can’t repair itself fast enough. And that’s why it dies. *** It has to self-destruct, or it transforms into a cancer cell. *** That is the alternative. So it usually self-destructs because if a cancer cell develops, specific damage results, there are other factors involved, but generally it dies."
Still way above my pay grade when it comes to biology. That said, I have a large investment in mitochondria and absolutely no interest in destroying it with a vaccine injection of LNPs.
Wasn’t there a post-1st dose case spike in 90 countries? Among them Mongolia and Vietnam, which had few cases before it but many after? That to me is the Worry Window.
90? I know there were quite a few - but who's to say that would not have happened absent Covid-vaccination? And then there are examples where no such spike occurred - quite notably, in the UK. Or take India - ok, there was a bit of vaccination at the same time as the spring wave - but vaccination continued without the wave. Kerala, of course, is the exception - and so it has become a worry window darling. Well, sure: Go cherry picking, you'll get cherries.
No such spike in th UK?(!) We had one of the first, in early January. Of course it was disguised partly by covid already being widespread.
Right, the winter wave turns back up on December 8, the exact day the Covid-vaccine roll-out starts. But then it turns around while the roll-out is still only at 2 million doses. 28 million more first doses and "worry window" entrances between February 10 and end of March, and yet the wave dies out (it's slightly prolonged due to March having the highest testing rates of the entire year).
There are parts that don't seem to fit, so I think there must be more factors at play. One obviously being the prevalence of the virus at the time, another possibly being that healthcare workers, care home staff and vaccinators were among the first being jabbed and were possibly infecting the elderly and infirm whose deaths then formed that January spike.
By the time younger people were being jabbed, the season had changed and they were less likely to come into contact with persons infected. Until summer when we had that strange spike in cases in people of around 40 and younger. Until that point I hadn't known more than one or two people with confirmed covid, but then I started to hear of many cases and nearly all were in recently jabbed. More recently still, my brother-in-law's daughter (15) caught it soon after being jabbed.
So my personal observations tell me that the 'worry window' is likely real, even if there are things we don't understand about it.
Childhood infections in summer 2021 are a tricky one, too - they seem to have increased among all ages, and therefore regardless of vaccine status. Increased susceptibility due to "expressed" spike by older household members, or vaccination, or decay of previously robust innate immunity? Only comparison of "partially vaccinated" infection rates vs unvaccinated per age group can really tell the difference, and I still haven't seen any smoke in that direction.
I think the 'worry window' wouldn't necessarily only affect the vaccinated. If it creates an increase in sick, symptomatic people then the virus would surely spread wider as a result.
Thanks for your reply. Yes, 90 … these did have to do with mass vaccination, not “a bit,” and we know there’s temporary lymphocytemia after the first dose, but certainly it’s hard to pin down all the variables.
That's way more countries than I can even name. I think I need to revisit the original stats one day - If it's a bunch of small hermit countries, that sounds like the virus riding on the shipment and distribution of the shots. Israel was still dosing up young people in July, in the middle of a "breakthrough wave" amongst the older vaccinated. The dashboard didn't show a high rate of "partially vaccinated" infections - it was about half of the unvaccinated per-100k rate. All month long.
Regarding the delta spread, wouldn't mere evolutionary pressure tend to make emerging variants more contagious?
Yes - and the theory that the vaccines placed escape pressure on spike to increase fitness against Covid-vaccinated is pretty strong (https://unglossed.substack.com/p/saving-private-mrnayn#footnote-anchor-2) - I still have trouble buying it, for the reasons outlined there.
Mechanistically, though, it has to be asked "how can SARS-CoV-2 become more contagious than regular coronavirus?" What molecular puzzle can it solve that the ubiquitous common cold hasn't already figured out? No one seems to have an answer. In reality the room for improvement on core replication and transmission competence/efficiency is probably quite low, which means the "super-seasonality" we are seeing is somehow a product of changes to the playing field, not the player. An albino tiger doesn't have to figure out jumping from scratch; it's already perfect at the things that are intrinsic to "tiger" - so Darwin doesn't come into play unless there's a change in climate etc.
Checks out. But I dunno, is SC2 reproductive rate supposed to be higher than common colds? Who's saying that? The seasonal sniffles are pretty transmissible already, IIUC.
Right, which accords with my suggestion that there is competition for "bandwidth." What is unique about SARS-CoV-2 - the tendency to trigger some type of pre-primed inflammatory response, leading to worse outcomes - doesn't overlay with contagiousness. So it's possible that rather than being an "albino tiger," it was an "albino tiger with webbed feed" that needed to fix some fundamentals. But it's also possible that, from a strict perspective of transmission fitness, it is just taking advantage of local differences and changes in "tiger recognition algorithms."