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Richard Sharpe's avatar

Kevin McKernan has some interesting comments on cytokine storms:

https://www.youtube.com/watch?v=v_T246fykZA

It's long and the comments occur after about 1 hour.

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Dr Linda's avatar

Makes sense. That is why I could never be successful as a research scientist. I don’t play well with liars and cowards.

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JS's avatar

Total side-bar, but have you seen this pre-print on spike accumulation in the brains and skull bone marrow of mice? https://www.biorxiv.org/content/10.1101/2023.04.04.535604v1.full

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Tardigrade's avatar

Maybe part of the reason for the continued existence of the cytokine-storm story is that immune suppression treatment (like corticosteroids? Prednisone?) seemed to work.

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Michael Dunn's avatar

I recall hearing about cytokine storm shortly after this all began in NY and it was something that almost seemed to be taken for granted but I don't recall the evidence that is was happening.

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Dr Linda's avatar

What is the point of insisting on “cytokine storm”? Is their a benefit?

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Brian Mowrey's avatar

If you are an immunologist you don’t get any funding for saying “immune system good.” You want to blame everything on immune response so people give your lab grants to find solutions for everything. And I think there was just a vacuum of actual research about the disease so the immune response narrative never got any scrutiny or push-back.

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Darrell O. Ricke, M.S., Ph.D.'s avatar

Excess TNF-alpha levels negatively impact B-cell maturation in germinal centers (Kenko etc al. Cell) in some COVID-19 patients; so, while not a cytokine storm - it is relevant for these patients.

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Brian Mowrey's avatar

That is discussed in TASD pt. 2. While mediated by a cytokine, it is immune suppression, not over-reaction as the CS narrative emphasizes

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May 19, 2023
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Darrell O. Ricke, M.S., Ph.D.'s avatar

Or, they are susceptible to reinfection! See Walgreens COVID index (graph 3 of 5) that vaccinated individuals have higher infection rates than the unvaccinated. Go vax!!!

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