This is all highly technical stuff, a lot of which I'm not truly equipped to understand, but I was horrified at those implications I did understand when this piece came out.
I'm researching something else right now, but just came upon a recent update on the Molnupiravir dossier. In this post, you were mostly discussing the drug's mutagenic potential in humans, but you also addressed something else in passing: "it appears, potentially, more “potent” in competing for polymerase selection and inducing viral mutagenesis (rather than inhibition of translation) than predecessors."
There are now people calling for Molnupiravir to be pulled due to it "driving viral mutation." The Nature article below doesn't go into detail about potential mechanisms at work, but "The study’s authors say the results suggest that Molnupiravir treatment has sparked the evolution of viral lineages carrying numerous mutations that, in at least some cases, have the capacity to spread to other individuals." Score another point for Team Told-You-So?
Odd. C>U is already the viruses most common swap. Omicron preserves this preference but lessens it a bit, with the counterpart G>A gaining some of that lost ground. So I don't think any inference is possible since Molnupiravir's mutations cannot "lean into" only one element of the C>U/G>A signature, it theoretically scores for both sides (see Wei, C. et al. Fig 2 in https://unglossed.substack.com/p/mouse-party) - why is the Forbes article claiming otherwise? Another spooky psy-op to blame M for what was already going to happen?
I cannot comprehend the level of disconnect, biologically and spiritually, that it takes to believe altering immune systems would be the plan...turning each person into some kinda Frankenstein...remember how that worked out?
A lot easier for humans to terraform Mars if we can sterilize this planet and practice on it first, that's the plan at any rate. Don't see what could go wrong.
that one, the rockets et al, thing, has become for me another litmus of whether someone is grounded here our not.....ok ness....what a sad existance it must be to live in space....i cannot wish it for anyone from the descriptions i hear so far....I hope to live out my time here on dusty earth....and strangely I am happy to hear there are now there are mushroom-based box coffins that will help us biodegrade correctly....without all the formaldehyde et al they use to prop up corpses. Sorry to be so graphic, but maybe we can change our burial habits in the midst of this carnage.....for the better....plants feed us our whole lives and what do we give them back? Silly?....plants feed everything.
I did read that one!, but loaned it out, or would re-read it...I am so happy about how the 'mushroom thing' has emerged, from Stamets and Sheldrake and others, into the mainstream. I use that Stamets 7 mix to make hot chocolate, and his story about how his mom healed breast cancer with mushrooms is pretty amazing, yes. I know Stamets is working with DARPA, probs lots to say there I dunno. I think mushrooms are the aliens in another form, here to hold it all together and also take it all apart as well (the real 'build back better'!) Would be a good investment to dry a bunch of mushrooms for my larder, so I will put that on my list too...They grow like crazy here in OR but my yard is full of inedible ones, maybe I can get some started on logs this year....thanks Johnsta.
Thank you for the alert! - I will take a look tomorrow AM, though the title itself definitely accords with my portrayal of the proper context for using nucleoside analogs. There were some more developments RE mutagenicity in the FDA recommendation debate - https://www.fda.gov/media/154418/download - perhaps you already covered them in your post!
Thank you for this extended explanation. I'd read that Molnupiravir could "integrate into the genetic material of mammalian cells, causing mutations as those cells replicate."
Of all the excellent substacks I've been reading on this issue, one thing they all have in common is their steadfast refusal to acknowledge the possibility that our 'authorities' intend to cause harm. Despite knowing of their willingness to commit mass murder by ventillator and midazolam, they refuse to believe the whole point of this exercise is something other than a combination of incompetence and greed.
With a study group size average of 3.4(?) you'd think shipping would be the most expensive part. It's worth wondering if the study/studies ever happened at all (at least the ones they claimed to have carried out). Here's an interesting appraisal of the early South African Oxford chimeric platform study- http://mileswmathis.com/monkeybus.pdf
Yes - though it's not clear if DNA replication errors would be such a catastrophe. There are error-checking guardrails, which are what the Feng et al. and Lu et al. papers suggest are responsible for more errors in mitochondria. Cancer is plausible, but might be a lot rarer than metabolic harms and the "teratogenic and/or embryocidal effects demonstrated in all animal species" with Ribavirin.
Most of the substacks are by authors who still stand to lose their economic worth and lifestyle if it turns out that both media and pharma are involved in a global depop conspiracy. I have no reason not to see the obvious.
Thank you, that's an interesting link - I'm halfway though. AstraZeneca might be the missing element to explain why variants of concern seemed to emerge during the trial rollouts, as if the trials were driving spike escape (which leaves unexplained why such variants would any advantage in the naive population before the mass roll-out). It's something I need to look more into.
Did I read that right? Mis-folded protein creation? As in prions and mad cow disease? And that these messed up molecules they are creating can then get into the environment? Are they really that crazy?
As in prions, yes. Which is not the only path to neurological harms anyway. So, it's very troubling that ribavirin is known to futz with people's minds - "depression, emotional lability, somnolence." And yet it's not recalled as an "antiviral"! Valopicitabin revealed neurotoxic effects in trials and was halted.
Ah, contextual titles - it's a sticky question. To avoid segueing into an aesthetic debate, I would just recommend renaming the titles during bookmarking. I've noticed I, myself, have to do this with basically all news and academic bookmarks as it is. Even things like the FDA approval page for Pfizer were getting lost until I renamed them.
Meanwhile until I figure out how to rescue the index page, which is now three months out of date, I don't mind fishing up anything with a comment request.
PS Can you consider adding some context to your titles - I bookmark quite a few of your articles not just for personal reference but to perhaps link to in my articles, and the cryptic headers don't offer much context in my list of covid bookmarks. Thanks! :-)
Baric. Seriously?! My mouth fell open. They do not even try to hide their intentions. Side note: you are an excellent writer. That was an enjoyable read, despite the sickening content ;)
After absorbing that gem, your article was timely and directly addressed my immediate question, which was "OK, so what keeps this potent mutagen out of places we don't want it?" And my second question, "is this just ivermectin with bonus ingredients so we can charge an arm and a leg for it?"
The idea that Molnupiravir's ulterior motive is to cover up the deficiencies of the vaccine, I'm not so much on board with, if only because such a conspiracy would require more efficiency and organization than I credit them with.
Screaming in my head at that video. "Hands the virus fake blocks dur dur." Your body also builds things out of blocks! It's so obvious! Also weird how most descriptions of the nucleoside analogue mechanism condense replication into one step. I wonder if figuring out what goes on inside a cell just isn't exciting to most people opining about SARS-CoV-2 on either side of the debate, including tons who are smarter than me.
As for efficiency, the pills are already manufactured and purchased in enough quantity to get the job done. All that remains is the approval. As I teased in the article, effective competition for CTP in cells (and causing harms thereby) isn't even required - just the pretense of that competition - to take the blame for all the effects that line up with harms from injected spike scripts. I hope you're right about the lack of intentional blame-shifting and I'm right that the harm doesn't actually happen; we'll see.
"I wonder if figuring out what goes on inside a cell just isn't exciting to most people"
I think mainstream thinking is that the average person only understands things at the bumper sticker level. The immune system doesn't exactly lend itself to that.
I am glad you wrote about the findings in India. This to me is just stunning. Trials halted because of no benefit and trials halted here because of findings of efficacy. Well - it doesnt get any weirder than that.
Which could be an artifact of different baseline treatment protocols (or local treatment fads) and thus severe outcome rates. Maybe they were all self-dosing ivermectin (I think most of the study was in Maharashtra which has not endorsed ivermectin, but I'm not sure). Or it's all junk - since it's very difficult to imagine a non-conspiratorial explanation for the expected authorization, I can't bring myself to credit the "promising" results of the press release to begin with.
Yes agree totally. It will be interesting to see how many "dropped out" of the Merck trial once we can look at all the data. Its interesting too - because 50% for hospitalization just isn't that great - really. Its the improvement in death that makes it a winner.
Did you see the new Monoclonal therapy from (I think) Astra - Zeneca? Supposively provides benefit that can last up to 6 months? Again - I am biased, but believe the that the fact that we wife on monoclonals has really cost us.
"Aspirin lowers risk of COVID: New findings support preliminary Israeli trial
The treatment reduced the risk of reaching mechanical ventilation by 44%. ICU admissions were lower by 43%, and an overall in-hospital mortality saw a 47% decrease."
That seems a bit funny. Without tracking down the actual studies I would imagine that the orthodox population is statistically driving up severe outcomes for the ‘non-aspirin’ group based on having higher exposure to the virus before the pseudo-vaccine rollout, but who knows...
I had wanted to add another vs but could not find a study that showed the effect. Study since located, so please consider this part of my previous comment...
vs
COVID-19 mortality risk correlates inversely with vitamin D3 status, and a mortality rate close to zero could theoretically be achieved at 50 ng/ml 25(OH)D3
"Stay home save lives" is probably the most egregious lie of all. No known outdoor transmission + Vit D production thanks to sunlight = likelihood of significant reduction in deaths due to COVID in non-LTC infectees.
NB: seeing some people shit on this study (possibly rightly so) and encourage salt grains to be taken.
IMO the immunity angle is solid, as is the deficiency in coloured skin people and seasonal aspect of flus and COVID in particular, where you expect sunlight exposure to be lowered and this Vit D / immune function to also be lowered.
This is all highly technical stuff, a lot of which I'm not truly equipped to understand, but I was horrified at those implications I did understand when this piece came out.
I'm researching something else right now, but just came upon a recent update on the Molnupiravir dossier. In this post, you were mostly discussing the drug's mutagenic potential in humans, but you also addressed something else in passing: "it appears, potentially, more “potent” in competing for polymerase selection and inducing viral mutagenesis (rather than inhibition of translation) than predecessors."
There are now people calling for Molnupiravir to be pulled due to it "driving viral mutation." The Nature article below doesn't go into detail about potential mechanisms at work, but "The study’s authors say the results suggest that Molnupiravir treatment has sparked the evolution of viral lineages carrying numerous mutations that, in at least some cases, have the capacity to spread to other individuals." Score another point for Team Told-You-So?
https://www.nature.com/articles/d41586-023-00347-z
Best!
Oh dear... apparently the mutations from M are the same mutations seen in Omicron?
https://twitter.com/LokiJulianus/status/1474219484164595712
Actually, I had that backwards. Molnupiravir favors U>C. This is even less present in pre-Omi than normal rate.
Odd. C>U is already the viruses most common swap. Omicron preserves this preference but lessens it a bit, with the counterpart G>A gaining some of that lost ground. So I don't think any inference is possible since Molnupiravir's mutations cannot "lean into" only one element of the C>U/G>A signature, it theoretically scores for both sides (see Wei, C. et al. Fig 2 in https://unglossed.substack.com/p/mouse-party) - why is the Forbes article claiming otherwise? Another spooky psy-op to blame M for what was already going to happen?
I cannot comprehend the level of disconnect, biologically and spiritually, that it takes to believe altering immune systems would be the plan...turning each person into some kinda Frankenstein...remember how that worked out?
A lot easier for humans to terraform Mars if we can sterilize this planet and practice on it first, that's the plan at any rate. Don't see what could go wrong.
that one, the rockets et al, thing, has become for me another litmus of whether someone is grounded here our not.....ok ness....what a sad existance it must be to live in space....i cannot wish it for anyone from the descriptions i hear so far....I hope to live out my time here on dusty earth....and strangely I am happy to hear there are now there are mushroom-based box coffins that will help us biodegrade correctly....without all the formaldehyde et al they use to prop up corpses. Sorry to be so graphic, but maybe we can change our burial habits in the midst of this carnage.....for the better....plants feed us our whole lives and what do we give them back? Silly?....plants feed everything.
plants and "fungi" https://www.merlinsheldrake.com/entangled-life
https://www.merlinsheldrake.com/videos
I did read that one!, but loaned it out, or would re-read it...I am so happy about how the 'mushroom thing' has emerged, from Stamets and Sheldrake and others, into the mainstream. I use that Stamets 7 mix to make hot chocolate, and his story about how his mom healed breast cancer with mushrooms is pretty amazing, yes. I know Stamets is working with DARPA, probs lots to say there I dunno. I think mushrooms are the aliens in another form, here to hold it all together and also take it all apart as well (the real 'build back better'!) Would be a good investment to dry a bunch of mushrooms for my larder, so I will put that on my list too...They grow like crazy here in OR but my yard is full of inedible ones, maybe I can get some started on logs this year....thanks Johnsta.
Great job summarizing this issue! The government and Big Pharma are doing their best to undermine confidence in all medicine.
I summarized some of the points of this article here: https://wholistic.substack.com/p/covid-drug-molnupiravir-toxic-chemotherapy - if I got anything wrong, please let me know.
Thank you for the alert! - I will take a look tomorrow AM, though the title itself definitely accords with my portrayal of the proper context for using nucleoside analogs. There were some more developments RE mutagenicity in the FDA recommendation debate - https://www.fda.gov/media/154418/download - perhaps you already covered them in your post!
Thank you for this extended explanation. I'd read that Molnupiravir could "integrate into the genetic material of mammalian cells, causing mutations as those cells replicate."
Of all the excellent substacks I've been reading on this issue, one thing they all have in common is their steadfast refusal to acknowledge the possibility that our 'authorities' intend to cause harm. Despite knowing of their willingness to commit mass murder by ventillator and midazolam, they refuse to believe the whole point of this exercise is something other than a combination of incompetence and greed.
With a study group size average of 3.4(?) you'd think shipping would be the most expensive part. It's worth wondering if the study/studies ever happened at all (at least the ones they claimed to have carried out). Here's an interesting appraisal of the early South African Oxford chimeric platform study- http://mileswmathis.com/monkeybus.pdf
""ChAdOx1 nCOV-19_ZA_phI/II”. Chimpanzee. Adenosin. Oxford"
None of the details seem to add up.
Yes - though it's not clear if DNA replication errors would be such a catastrophe. There are error-checking guardrails, which are what the Feng et al. and Lu et al. papers suggest are responsible for more errors in mitochondria. Cancer is plausible, but might be a lot rarer than metabolic harms and the "teratogenic and/or embryocidal effects demonstrated in all animal species" with Ribavirin.
Most of the substacks are by authors who still stand to lose their economic worth and lifestyle if it turns out that both media and pharma are involved in a global depop conspiracy. I have no reason not to see the obvious.
Thank you, that's an interesting link - I'm halfway though. AstraZeneca might be the missing element to explain why variants of concern seemed to emerge during the trial rollouts, as if the trials were driving spike escape (which leaves unexplained why such variants would any advantage in the naive population before the mass roll-out). It's something I need to look more into.
This is one rabbit hole I wish I hadn't gone down. :-(
Oh boy! "Gates Foundation will provide $120 million to ensure generic production of Merck’s Covid-19 pill"
https://www.statnews.com/2021/10/20/covid19-merck-gates-pill-patents-who/
Trying to poison the whole world (which means subsidizing the pill) while cashing in (which means gouging wealthy nations), i.e. Billionaire Twister!
Did I read that right? Mis-folded protein creation? As in prions and mad cow disease? And that these messed up molecules they are creating can then get into the environment? Are they really that crazy?
As in prions, yes. Which is not the only path to neurological harms anyway. So, it's very troubling that ribavirin is known to futz with people's minds - "depression, emotional lability, somnolence." And yet it's not recalled as an "antiviral"! Valopicitabin revealed neurotoxic effects in trials and was halted.
Ah, contextual titles - it's a sticky question. To avoid segueing into an aesthetic debate, I would just recommend renaming the titles during bookmarking. I've noticed I, myself, have to do this with basically all news and academic bookmarks as it is. Even things like the FDA approval page for Pfizer were getting lost until I renamed them.
Meanwhile until I figure out how to rescue the index page, which is now three months out of date, I don't mind fishing up anything with a comment request.
PS Can you consider adding some context to your titles - I bookmark quite a few of your articles not just for personal reference but to perhaps link to in my articles, and the cryptic headers don't offer much context in my list of covid bookmarks. Thanks! :-)
Baric. Seriously?! My mouth fell open. They do not even try to hide their intentions. Side note: you are an excellent writer. That was an enjoyable read, despite the sickening content ;)
Thank you. I laughed aloud at "sickening" but only because it's so accurate.
First, thanks for the introduction to Pinky and the Brain. I need to go watch some of those.
STAT News is geared toward the above average, Big-Pharma-supporting reader. So I found this short explanatory video of Molnupiravir especially [not] helpful: https://www.statnews.com/2021/10/13/molnupiravir-merck-covid-pill-how-it-works/
After absorbing that gem, your article was timely and directly addressed my immediate question, which was "OK, so what keeps this potent mutagen out of places we don't want it?" And my second question, "is this just ivermectin with bonus ingredients so we can charge an arm and a leg for it?"
The idea that Molnupiravir's ulterior motive is to cover up the deficiencies of the vaccine, I'm not so much on board with, if only because such a conspiracy would require more efficiency and organization than I credit them with.
Screaming in my head at that video. "Hands the virus fake blocks dur dur." Your body also builds things out of blocks! It's so obvious! Also weird how most descriptions of the nucleoside analogue mechanism condense replication into one step. I wonder if figuring out what goes on inside a cell just isn't exciting to most people opining about SARS-CoV-2 on either side of the debate, including tons who are smarter than me.
As for efficiency, the pills are already manufactured and purchased in enough quantity to get the job done. All that remains is the approval. As I teased in the article, effective competition for CTP in cells (and causing harms thereby) isn't even required - just the pretense of that competition - to take the blame for all the effects that line up with harms from injected spike scripts. I hope you're right about the lack of intentional blame-shifting and I'm right that the harm doesn't actually happen; we'll see.
"I wonder if figuring out what goes on inside a cell just isn't exciting to most people"
I think mainstream thinking is that the average person only understands things at the bumper sticker level. The immune system doesn't exactly lend itself to that.
"at the bumper sticker level"
Or for the Zoomers, at the meme level.
They're analogous :)
Guess I dated myself.
More support for your article. https://trialsitenews.com/merck-ignores-molnupiravirs-cytotoxicity/
Molnupiravir is 10 out of 10 on the insanity scale, right up there with the DNA vaccine being trialed in India, which permanently modifies your DNA to produce spike protein. https://www.pri.org/stories/2021-10-11/india-will-soon-roll-out-dna-vaccine-coronavirus-it-s-latest-example-how-covid-19
The fact that nature actually works just makes them so angry!
I am glad you wrote about the findings in India. This to me is just stunning. Trials halted because of no benefit and trials halted here because of findings of efficacy. Well - it doesnt get any weirder than that.
Which could be an artifact of different baseline treatment protocols (or local treatment fads) and thus severe outcome rates. Maybe they were all self-dosing ivermectin (I think most of the study was in Maharashtra which has not endorsed ivermectin, but I'm not sure). Or it's all junk - since it's very difficult to imagine a non-conspiratorial explanation for the expected authorization, I can't bring myself to credit the "promising" results of the press release to begin with.
Yes agree totally. It will be interesting to see how many "dropped out" of the Merck trial once we can look at all the data. Its interesting too - because 50% for hospitalization just isn't that great - really. Its the improvement in death that makes it a winner.
Did you see the new Monoclonal therapy from (I think) Astra - Zeneca? Supposively provides benefit that can last up to 6 months? Again - I am biased, but believe the that the fact that we wife on monoclonals has really cost us.
"The pill reduced the risk of hospitalization or death by about 50%,” Merck and its partner, Ridgeback Biotherapeutics, said in a statement Friday"
https://www.businessinsider.com.au/merck-stock-price-antiviral-pill-cuts-covid-19-hospitalizations-and-deaths-2021-10
vs
"Aspirin lowers risk of COVID: New findings support preliminary Israeli trial
The treatment reduced the risk of reaching mechanical ventilation by 44%. ICU admissions were lower by 43%, and an overall in-hospital mortality saw a 47% decrease."
https://www.jpost.com/health-and-wellness/aspirin-lowers-risk-of-covid-new-findings-support-preliminary-israeli-trial-681127
If covid-19 is indeed a vascular disease rather than respiratory one, the use of aspirin makes sense to counter micro-clotting.
That seems a bit funny. Without tracking down the actual studies I would imagine that the orthodox population is statistically driving up severe outcomes for the ‘non-aspirin’ group based on having higher exposure to the virus before the pseudo-vaccine rollout, but who knows...
I had wanted to add another vs but could not find a study that showed the effect. Study since located, so please consider this part of my previous comment...
vs
COVID-19 mortality risk correlates inversely with vitamin D3 status, and a mortality rate close to zero could theoretically be achieved at 50 ng/ml 25(OH)D3
https://www.medrxiv.org/content/10.1101/2021.09.22.21263977v1.full
"Stay home save lives" is probably the most egregious lie of all. No known outdoor transmission + Vit D production thanks to sunlight = likelihood of significant reduction in deaths due to COVID in non-LTC infectees.
NB: seeing some people shit on this study (possibly rightly so) and encourage salt grains to be taken.
IMO the immunity angle is solid, as is the deficiency in coloured skin people and seasonal aspect of flus and COVID in particular, where you expect sunlight exposure to be lowered and this Vit D / immune function to also be lowered.
Thank you for this excellent research. In a better world, this article would have thousands of views and likes.
Thanks - though surely in a better world, everything I just wrote would be fiction!