Feb 27, 2022·edited Feb 27, 2022Liked by Brian Mowrey
The cmRNA vaccines are coded with Pseudouridine, an isomer of Uridine. This means that the spike proteins will be isomeric as well (as will the antibodies). The result of this is that the situation is much worse than that described in the paper: the heat shock proteins.
Sars-Cov-2 and M. bovis include identical genome sequences which include heat shock proteins. During a thermal shock, these proteins will be activated (as will the binding isomeric antibodies), with huge consequences on the DNA transcription phenomenon.
“The response to thermal stress in yeast is one of the most dynamic examples of transcriptional control known. Within 1 to 5 min of temperature upshift (30°C to 39°C), dramatic changes in protein-DNA interactions take place within HSP gene promoters, and these are accompanied by equally dramatic increases in transcription.”
“Lipid mediated gene transfer (lipofection) has been widely used to transfer genes into various cell types (1–4). Lipofection works very well in many cell lines, resulting in high transient transfection efficiencies (our observations). However, the rate of DNA integration into the genome following lipid-mediated transfection is relatively low (5) as compared to other methods, such as retroviral systems. This inefficient integration has been thought to be a major disadvantage of plasmid vectors and has limited their use in gene therapy trials.
We have attempted to overcome this hurdle by achieving higher rates of stable integrants in lipid-mediated transfections through treating the transfected cells with a mild heat shock.”
“Another factor commonly overlooked is the fact that bacteria produce reverse transcriptase via retrons, suggesting possible viral-bacterial interaction. Indeed, LPS is known to strongly impact the process:
“When we stimulated spleen cells with lipopolysaccharide (LPS), L1 mRNA levels apparently increased about 4-fold in the presence of AID and about 17-fold in its absence””
There is also this: “the possibility of telomerase HTERT, which is a reverse transcriptase enzyme, having any potential to insert the mRNA spike protein sequence into telomeric DNA.”
From the wmcresearch website:
"SARS-CoV-2 MAY OR MAY NOT WRITE ITSELF INTO YOUR DNA, BUT IT IS ALMOST CERTAINLY CUTTING/PASTING YOUR GENES, WRITING THEM BACK “WRONG" INTO YOUR DNA. LINE-1 ELEMENTS MUST BE TESTED IN ALL THOSE WITH COVID.
Retrotransposons (also called Class I transposable elements or transposons via RNA intermediates) are a type of genetic component that copy and paste themselves into different genomic locations (transposon) by converting RNA back into DNA through the process reverse transcription using an RNA transposition Retrotransposons can be further subdivided into two subclasses: those with Long-Terminal Repeats (LTR) and those without (non-LTR). LTR elements, also known as endogenous retroviruses (ERVs), comprise ~8 % of the human genome. LTR ) elements are thought to be inactive in the human lineage. That is, until SARS-CoV-2 activates them. This is why the HERV-K protein has never before been seen circulating in the body."
Thanks for the update to that post. The type of cells that a researcher uses should always be scrutinized for their ability to either mimic what could happen in human models or if they are representative of the process or intended goals overall. The cancer cells may have been used for their shorter replication and because LNPs may aggregate within the liver but the dynamics are very different when you add things to a petri dish rather than inject it and see where it carries and what the entire organism does with the compound.
Regardless, the most important thing is that someone is willing to examine criticisms and evaluate them accordingly. Honestly, someone may come by and say that my correction itself is wrong, although I can see why there may be plenty of confusion. The post wording wasn't very direct in what they meant.
Like I said the study is interesting but I think we will need more evidence to determine the dangers or harms of such a finding, if it is reproducible in human models.
Hi Brian. Do you want to help me with genetic analysis for an article I want to write? I can advertise your substack in that article and give y ou proper credit, of course.
one must not forget that synthesis of the spike protein is also occurring at the same time.If presented to the adjacent cells or even in the medium ,several pathways may be activated ,be it via TLRs 2 or 4 or others such as CD 209/ L-SIGN.Another publication ( not yet peer reviewed) presented evidence for activation of HERV-W in some volunteer lymphocytes upon spike exposure.There could be also ER stress.
The cmRNA vaccines are coded with Pseudouridine, an isomer of Uridine. This means that the spike proteins will be isomeric as well (as will the antibodies). The result of this is that the situation is much worse than that described in the paper: the heat shock proteins.
Sars-Cov-2 and M. bovis include identical genome sequences which include heat shock proteins. During a thermal shock, these proteins will be activated (as will the binding isomeric antibodies), with huge consequences on the DNA transcription phenomenon.
“The response to thermal stress in yeast is one of the most dynamic examples of transcriptional control known. Within 1 to 5 min of temperature upshift (30°C to 39°C), dramatic changes in protein-DNA interactions take place within HSP gene promoters, and these are accompanied by equally dramatic increases in transcription.”
“Lipid mediated gene transfer (lipofection) has been widely used to transfer genes into various cell types (1–4). Lipofection works very well in many cell lines, resulting in high transient transfection efficiencies (our observations). However, the rate of DNA integration into the genome following lipid-mediated transfection is relatively low (5) as compared to other methods, such as retroviral systems. This inefficient integration has been thought to be a major disadvantage of plasmid vectors and has limited their use in gene therapy trials.
We have attempted to overcome this hurdle by achieving higher rates of stable integrants in lipid-mediated transfections through treating the transfected cells with a mild heat shock.”
“Another factor commonly overlooked is the fact that bacteria produce reverse transcriptase via retrons, suggesting possible viral-bacterial interaction. Indeed, LPS is known to strongly impact the process:
“When we stimulated spleen cells with lipopolysaccharide (LPS), L1 mRNA levels apparently increased about 4-fold in the presence of AID and about 17-fold in its absence””
There is also this: “the possibility of telomerase HTERT, which is a reverse transcriptase enzyme, having any potential to insert the mRNA spike protein sequence into telomeric DNA.”
From the wmcresearch website:
"SARS-CoV-2 MAY OR MAY NOT WRITE ITSELF INTO YOUR DNA, BUT IT IS ALMOST CERTAINLY CUTTING/PASTING YOUR GENES, WRITING THEM BACK “WRONG" INTO YOUR DNA. LINE-1 ELEMENTS MUST BE TESTED IN ALL THOSE WITH COVID.
Retrotransposons (also called Class I transposable elements or transposons via RNA intermediates) are a type of genetic component that copy and paste themselves into different genomic locations (transposon) by converting RNA back into DNA through the process reverse transcription using an RNA transposition Retrotransposons can be further subdivided into two subclasses: those with Long-Terminal Repeats (LTR) and those without (non-LTR). LTR elements, also known as endogenous retroviruses (ERVs), comprise ~8 % of the human genome. LTR ) elements are thought to be inactive in the human lineage. That is, until SARS-CoV-2 activates them. This is why the HERV-K protein has never before been seen circulating in the body."
Thanks for the update to that post. The type of cells that a researcher uses should always be scrutinized for their ability to either mimic what could happen in human models or if they are representative of the process or intended goals overall. The cancer cells may have been used for their shorter replication and because LNPs may aggregate within the liver but the dynamics are very different when you add things to a petri dish rather than inject it and see where it carries and what the entire organism does with the compound.
Regardless, the most important thing is that someone is willing to examine criticisms and evaluate them accordingly. Honestly, someone may come by and say that my correction itself is wrong, although I can see why there may be plenty of confusion. The post wording wasn't very direct in what they meant.
Like I said the study is interesting but I think we will need more evidence to determine the dangers or harms of such a finding, if it is reproducible in human models.
Hi Brian. Do you want to help me with genetic analysis for an article I want to write? I can advertise your substack in that article and give y ou proper credit, of course.
https://twitter.com/ichudov/status/1497767825896878083
one must not forget that synthesis of the spike protein is also occurring at the same time.If presented to the adjacent cells or even in the medium ,several pathways may be activated ,be it via TLRs 2 or 4 or others such as CD 209/ L-SIGN.Another publication ( not yet peer reviewed) presented evidence for activation of HERV-W in some volunteer lymphocytes upon spike exposure.There could be also ER stress.