I agree with you that it is unlikely that whatever is happening is changing the germ line. However, you say:
"And so, since there are millions of sperm that vie for fusion with the egg, individual LNPs would have to deliver vaccine mRNA which would then have to successfully incorporate into most or all of these sperm cells, to make it remotely likely that this mysterious genetic gift would pass on to offspring."
Wouldn't it really be the spermatogonial stem cells that would be modified because they are the things that actually generate the haploid spermatozoa?
Maybe I am being too technical, but sometimes the details matter.
Thanks again, Brian. I admire your patience with these articles. I've said it before, but I think the reviewers are falling down on the job. They should have flagged the question of whether multiple litters in the first generation, or multiple generations of litters. Also, the authors would probably respond to a direct query from readers, such as yourself, asking for a clarification.
if the synthetic genetic material is 'just' transiently out there reprogramming the jobs of few cells, how to explain super fast growing cancers of entire organs, 4 different types in one patient for example?
Reviews seem split between the 2nd, 3rd, and 4th litters being successive generations and, conversely, serial litters from the same 2 parents. I haven't read the study myself; you're sure it's the former?
I am a little tired and didn't read this thoroughly, but beta- glucan activates dectin-1 receptors which spike effects, so it is protective against fungal infections related to spike toxicity. I use Nutritional Yeast flakes daily as a beta glucan source. I am not fond of fungal infections.
I agree with you that it is unlikely that whatever is happening is changing the germ line. However, you say:
"And so, since there are millions of sperm that vie for fusion with the egg, individual LNPs would have to deliver vaccine mRNA which would then have to successfully incorporate into most or all of these sperm cells, to make it remotely likely that this mysterious genetic gift would pass on to offspring."
Wouldn't it really be the spermatogonial stem cells that would be modified because they are the things that actually generate the haploid spermatozoa?
Maybe I am being too technical, but sometimes the details matter.
I really appreciate the attitude and motivation you expressed in your last paragraphs. Please continue your devil's advocacy!
Thanks again, Brian. I admire your patience with these articles. I've said it before, but I think the reviewers are falling down on the job. They should have flagged the question of whether multiple litters in the first generation, or multiple generations of litters. Also, the authors would probably respond to a direct query from readers, such as yourself, asking for a clarification.
if the synthetic genetic material is 'just' transiently out there reprogramming the jobs of few cells, how to explain super fast growing cancers of entire organs, 4 different types in one patient for example?
Reviews seem split between the 2nd, 3rd, and 4th litters being successive generations and, conversely, serial litters from the same 2 parents. I haven't read the study myself; you're sure it's the former?
I am a little tired and didn't read this thoroughly, but beta- glucan activates dectin-1 receptors which spike effects, so it is protective against fungal infections related to spike toxicity. I use Nutritional Yeast flakes daily as a beta glucan source. I am not fond of fungal infections.