Your footnote 18 is interesting. I don't recall seeing ( or noticing) a Kaplan-Meier type graph with a logarithmic X-scale- usually the Y-scale is logarithmic.
Furthermore, if I can indulge my "Conspiracy Theory" tin hat, the cryogenic requirements kept the injections out of the hands and offices of GP's and Nurse Practitioners. I know that they are given by corporate pharmacies in the USA, but they are tightly held north of the border. This is particularly important- I talked a particularly feisty patient into the "H1N1" vaccine when current. She did not feel well for a week, and was not hesitant to give me a piece of her mind!
It is much easier to dismiss someone else's AE's than those you have induced yourself. It also reduces the opportunities for "AirBalls" or saline shots.
This took a little bit of rereading to understand, but it's all extremely fascinating. This is why you asked the questions about the endosomes! My idea was based on the notion that the size of the LNPs would dissuade the uptake of the LNPs in endosomes. Of course I clearly overlooked the idea that the LNPs are the same size as viruses. Why wouldn't there then be a possibility of endosomal uptake? My mistake on overlooking this!
It is quite ironic that all of these endeavors to examine SARS-COV2 under a microscope may actually indicate that there's a lot about other viruses and immunology as a whole that we do not know about. I think it's one of the biggest issues we are seeing where people are finding overlaps with SARS-COV2 and attributing it to other viruses, essentially making SARS-COV2 out to be a "Frankenvirus" (or to use the term more appropriately gain of function's frankenvirus). So what we may really be seeing is something that has been happening across other virus strains. It's only now, through constant research and surveillance that we are discovering these pathways.
One thing to point out with the endosomal route would be what aspect of the LNP is eliciting the uptake. I believe in your model your argument suggests the PEG playing a role which would be quite interesting. The article you provided to me suggesting a mimic of LDL cholesterol may suggest that the cholesterol may be providing its own response which would also justify the possible endosomal uptake as well! Plenty of things to think about with this post.
Check the iccosome story from John G.Tew…To me the exosomes shown where not of a common size and greater .The idea that PEG ABs could be important is also interesting
Consider me stupid, and forgive me for not being as able to understand as I wish I was. Is the big point that the long term existence of vaccine RNA and other products associated cause a chronic or auto-immune disease state of some sort?
I could hear vaccine proponents saying that long term antigen presence will allow long term antibody response (and therefore, protection, even though data doesn’t seem to support that). Or is the point that the sequestered RNA is responsible for OAS and therefore will be useless for variants? I can’t remember the nuances of immune system function, so will you be doing an “immunity for dummies” version? Thank you!
Well of course there’s no reason anyone should think “nature” in any way superior, after all, “nature” has only been tinkering for a billion years, we’ve been at it for a few hundred, and we’re super duper smart.
Your footnote 18 is interesting. I don't recall seeing ( or noticing) a Kaplan-Meier type graph with a logarithmic X-scale- usually the Y-scale is logarithmic.
Furthermore, if I can indulge my "Conspiracy Theory" tin hat, the cryogenic requirements kept the injections out of the hands and offices of GP's and Nurse Practitioners. I know that they are given by corporate pharmacies in the USA, but they are tightly held north of the border. This is particularly important- I talked a particularly feisty patient into the "H1N1" vaccine when current. She did not feel well for a week, and was not hesitant to give me a piece of her mind!
It is much easier to dismiss someone else's AE's than those you have induced yourself. It also reduces the opportunities for "AirBalls" or saline shots.
This took a little bit of rereading to understand, but it's all extremely fascinating. This is why you asked the questions about the endosomes! My idea was based on the notion that the size of the LNPs would dissuade the uptake of the LNPs in endosomes. Of course I clearly overlooked the idea that the LNPs are the same size as viruses. Why wouldn't there then be a possibility of endosomal uptake? My mistake on overlooking this!
It is quite ironic that all of these endeavors to examine SARS-COV2 under a microscope may actually indicate that there's a lot about other viruses and immunology as a whole that we do not know about. I think it's one of the biggest issues we are seeing where people are finding overlaps with SARS-COV2 and attributing it to other viruses, essentially making SARS-COV2 out to be a "Frankenvirus" (or to use the term more appropriately gain of function's frankenvirus). So what we may really be seeing is something that has been happening across other virus strains. It's only now, through constant research and surveillance that we are discovering these pathways.
One thing to point out with the endosomal route would be what aspect of the LNP is eliciting the uptake. I believe in your model your argument suggests the PEG playing a role which would be quite interesting. The article you provided to me suggesting a mimic of LDL cholesterol may suggest that the cholesterol may be providing its own response which would also justify the possible endosomal uptake as well! Plenty of things to think about with this post.
Check the iccosome story from John G.Tew…To me the exosomes shown where not of a common size and greater .The idea that PEG ABs could be important is also interesting
👏👏👏 fascinating way to present this information! Thank you! 💜
Consider me stupid, and forgive me for not being as able to understand as I wish I was. Is the big point that the long term existence of vaccine RNA and other products associated cause a chronic or auto-immune disease state of some sort?
I could hear vaccine proponents saying that long term antigen presence will allow long term antibody response (and therefore, protection, even though data doesn’t seem to support that). Or is the point that the sequestered RNA is responsible for OAS and therefore will be useless for variants? I can’t remember the nuances of immune system function, so will you be doing an “immunity for dummies” version? Thank you!
Well of course there’s no reason anyone should think “nature” in any way superior, after all, “nature” has only been tinkering for a billion years, we’ve been at it for a few hundred, and we’re super duper smart.
Reading this will be my 'Sunday night fights'....I so appreciate your quality/frequency ratio.