In an FB group I drop in on once in a while, a private group that reports "died suddenly" cases, I've seen one or two posts in the past two months describing rapid mental decline in individuals who took the mRNA shots. The symptoms as described sounded a lot like mad cow disease, CJD. I've been wondering why that wouldn't happen at maybe low frequencies. Seneff and Nigh's paper in the IJVTPR V2 May 10 2021 pp 38-79 discusses possible prion diseases from the shots (pp59-62). I'm pretty sure you've seen the paper. A lot seems speculative but does touch on areas that most of us vaccine-skeptic-kooks worry about. Prion disease is one of them.
Family data point here: my youngest sister took 3 Moderna shots and has been suffering dizziness ever since maybe the second one of March or April 2021. Her neurologist says its not MS, told it was probably her ears. Her ENT was dismissive and nasty, hateful really in the way she said it wasn't her ears. So she's in the dark on this. Is it some kind of demyelination? Will it progress to something worse? She's my baby sister, and to see her struggling with this finally made me understand how people can get angry enough to...well, never mind.
Actually I wasn't aware of that part of the Seneff / Nigh paper; I will take a look.
Yes, low frequencies. I shouldn't have said "little, if any" in my reply to Luterra below. I have definitely seen isolated cases of what looks like dementia this summer, once in a young but extraordinarily unhealthy dude. Like he could talk with normal intonation but couldn't finish a sentence; so I think that suggests recent, rapid onset. Other similar cases have been more elderly. A relative had brain fog for six months and then weirdly got better after the so-called booster.
So I think prion disease will happen sometimes, as a fraction of what is probably a whole universe of neurological harms the shots can cause.
I am sorry to hear about your sister. There's so many things that could cause dizziness - including cardiac / blood pressure stuff which is maybe the most common serious AE.
Could the young possible-dementia-sufferer possibly have been a heavy THC user? I've been seeing a lot of very dull witted looking younger people and just figured it was drugs.
My last two years teaching physics at a state university, 2017-2019, I noticed even some majors were heavily drugged.
There wasn't any spacing out in a true sense. More like fully awake but confused and unable to hold onto any thought. Had a lot of other things going on, but the mental aspect made it seem like he wouldn't be out on his own if this was his lifelong state. So I pegged it as a likely recent decline.
Thanks Brian. It's a delicate subject because she knows how I think about the mRNA shots, fine line between trying to help and rubbing it in. She's had workups to see if it's cardio. Awful thing is her four young daughters have all had the shots and two struggled with severe POTS afterward and no one made the connection. Except me, and again, it's a touchy subject.
Sis is in same boat as a lot of shot survivors. No one has any idea what's the matter.
Thanks - So, Nothing much new there. Tetz, Tetz, yet again. Improper use of PLAAC.
I wonder if "'prion-like' does not mean prionogenic" will be my new "OAS is not real" campaign. It's interesting that "prion" has some verbal associations with sin; "perversion," "pry," "prey on." Superstition and moral panic isn't immune to sloppy science terminology.
*edit: Ah, the exosomes / vagus nerve part is definitely relevant. "We hypothesize that exosomes released from immune cells in the spleen travel up the vagus nerve to reach the brain stem nuclei, and they deliver their toxic cargo, which can include not only the spike protein but also intact mRNA molecules that encode the protein, to recipient cells in the brain." I might include that in an edit. *edit: It's now in as footnote 12.
There was a Montagnier and Perez paper where they found 26 recent cases of CJD death in France, indicating a much higher rate than the 1 CJD death per year that would be normal. I am having a hard time finding a pdf of the full text of that study now. My original link goes to an empty researchgate page and I neglected to download it. There was an article on TrialSite News written discussing the paper and some other cases of CJD.
Thank you for that. The information out of France is very interesting. CJD is very rare most of the time and to hear of it at rates like that is disturbing.
Apparently FB deleted the "Died Suddenly News" group (with 300k members) but the owner reinstated it somehow. I checked it this morning. Reports arising of rapid mental decline in elderly vaxxed.
I think from what I've seen of doctors I know, very few will poke into a connection of CJD with the shots. Same for nurses. They prefer to whistle past the graveyard.
Yeah, that was the follow-up to the first paper as cited above. I don’t know that it adds a lot to the first paper since it focuses on the limited, molecular evidence for innate immune reprogramming. Sure, but, lots of non-mRNA vaccines have been found to reprogram innate immunity (https://unglossed.substack.com/i/71561323/context-non-specific-effects-are-common) so how is this a warning sign for mRNA specifically?
Personally I do think the anecdotes and trends (hello, monkeypox) support innate immune suppression due to these injections, ie some form of VAIDS. But how could they not — just by causing injury and inflammation they will have the same immune suppressive effect as diabetes, for example. So I’m trying to keep is simple as far as worrying about that.
Why would they research it? They’ll just tell everyone it’s “long COVID”. The great mass of NPCs are totally used to that explanation for pretty much everything.
Stepping back to the 10,000 foot level: Prion protein is a very small target (considering that prion disease is extremely rare and has not been - to our knowledge - triggered by any of the novel proteins or complex biomolecules to which we have exposed ourselves over the past century, nor does it have any known natural triggers except for misfolded prion proteins from humans and closely-related species), and the virus and vaccine are a rather small gun (with respect to the *number* of novel molecules being introduced into the body).
This makes me *extremely* skeptical of any claims that any of this business will cause prion disease, at least by your mechanism #1 of direct molecular interactions leading to misfolding.
There are hundreds of specific mechanisms by which novel mRNA vaccines could cause immune dysfunction, perhaps thousands of potential molecular interactions by which they could be carcinogenic, quite a few mechanisms by which they could trigger amyloid formation, and comparably very few ways in which they could specifically induce human prion protein to take on a pathogenic conformation.
My own version of Occam's Razor says that if these shots fail in the sense of really messing up a lot of human bodies, it's much more likely to be in an arena that has an abundance of possible failure modes. My top three, so far, are:
1. Amyloid clotting leading to cardiovascular consequences and effectively to premature aging of the cardiovascular system. As this appears to be spike-triggered, it occurs in response to both infection and vaccination (although maybe Omicron spike is less amyloidogenic?).
2. Immune dysfunction, largely arising from the confusing self/non-self signals conveyed by a foreign protein expressed by otherwise healthy cells repeatedly and for long periods. This potentially includes tolerance leading to increased covid susceptibility/severity, autoimmunity, immune suppression, and cancer proliferation (although admittedly there are also potential mechanisms of carcinogenicity that don't involve immune disruption).
3. Disruption of the process by which the virus and the collective human immune system reach evolutionary equilibrium, potentially resulting in enhanced rates of immune escape mutations, emergence of more dangerous variants, and more virus deaths than would otherwise have occurred.
Ah - but regarding “has not been triggered,” none of those precedents exonerates a transfected RNA molecule with G4 motifs! Regarding size, prion protein is being expressed all the time, akin to a housekeeping molecule, though perhaps not in all tissues. Or that was the gist I got of the current understanding. So from a theoretical framework I more envision their being a prion expression “highway” that the mRNA molecule has to cross on its way from LNP/endosome to ribosome. But LNP landing in prion-protein-expressing cells might be rare and the insensitivity to deformed prion protein in isolated cells from a disease standpoint might be quite high. So I’m not super concerned given that I don’t actually see much, if any cognitive decline in the vaxxed IRL.
Agree on 1, though I think the “both infection and vaccination” part will be less accurate in the young. And 2. I think I would keep 3 on the back burner given that I don’t view evolution as driving the story as opposed to continual lab manipulation.
Oct 11, 2022·edited Oct 11, 2022Liked by Brian Mowrey
By "size", I mean that there are 20,000 human proteins with which spike, modified mRNA, or lipid nanoparticles could potentially interact in a harmful way. Prion protein is just one of these, and moreover the molecular "key" to misfolding prion protein is presumably rather precise (along the lines of an enzyme-substrate interaction) and the background rate of prion disease is so low that even a 10-fold increase would hardly be catastrophic.
I agree that the abundance of G-quadruplexes in the modified mRNA is concerning, but at the same time G4 motifs are quite common and quadruplexes are probably present in all cells at all times to some degree.
As for 1., yes I would expect most young folks to get far more systemic spike from vaccination than from infection - especially in the Omicron era.
As for 3., the virus is definitely evolving. We have two potential lab releases but also ongoing mutation in both humans and animal reservoirs (e.g. white-tailed deer). Geert Vanden Bossche continues to issue dire warnings about the super-deadly-to-the-vaccinated variant that is sure to appear in the next few months (always in the next few months...) due to a variety of mechanisms involving innate immune suppression, high titers of poorly-neutralizing antibodies masking viral epitopes, and antibody-dependent enhancement. (e.g. https://www.voiceforscienceandsolidarity.org/videos-and-interviews/it-is-5-past-12)
I take it you don't put much stock in his claims? I can't say that I do either, although to the extent that mass vaccination maintains artificially high levels of poorly-matched antibodies and (via ADEI, tolerance, immune suppression, or any other mechanism) appears to lead to higher rates of ongoing population-level infection than would otherwise have occurred, I would expect it to have some influence on the evolutionary trajectory of the virus for good or ill, probably ill.
G4 motifs are common in regulatory genes and untranslated regions but less in coding RNA, so sort of a bride before the wedding deal as far as prion proteins should see. But still, same caveat at the end as before.
3 - I always feel as if vanden Bossche is going to pull some ace out of his sleeve that strengthens his theory. Not after his latest video. The essential problem is everything rests on "the toothless wolves with oven mitt hands will create escape pressure on the deer." No they won't. The genes of deer can't see what doesn't eat them; the genes of SARS-CoV-2 can't see non-neutralizing antibodies. You need to kill to put pressure. This is so fundamental to natural selection and he flaunts it all the time.
His attempt to imply some back-door to that rule with masking / conserved epitope hop-scotch is just intellectual Ponzi-scheme-ism.
Thank you - barrels of both Captain and Diet Coca Cola were consumed in the production of the same content. The circle of Captain, like the circle of life, goes on forever.
In an FB group I drop in on once in a while, a private group that reports "died suddenly" cases, I've seen one or two posts in the past two months describing rapid mental decline in individuals who took the mRNA shots. The symptoms as described sounded a lot like mad cow disease, CJD. I've been wondering why that wouldn't happen at maybe low frequencies. Seneff and Nigh's paper in the IJVTPR V2 May 10 2021 pp 38-79 discusses possible prion diseases from the shots (pp59-62). I'm pretty sure you've seen the paper. A lot seems speculative but does touch on areas that most of us vaccine-skeptic-kooks worry about. Prion disease is one of them.
Family data point here: my youngest sister took 3 Moderna shots and has been suffering dizziness ever since maybe the second one of March or April 2021. Her neurologist says its not MS, told it was probably her ears. Her ENT was dismissive and nasty, hateful really in the way she said it wasn't her ears. So she's in the dark on this. Is it some kind of demyelination? Will it progress to something worse? She's my baby sister, and to see her struggling with this finally made me understand how people can get angry enough to...well, never mind.
Actually I wasn't aware of that part of the Seneff / Nigh paper; I will take a look.
Yes, low frequencies. I shouldn't have said "little, if any" in my reply to Luterra below. I have definitely seen isolated cases of what looks like dementia this summer, once in a young but extraordinarily unhealthy dude. Like he could talk with normal intonation but couldn't finish a sentence; so I think that suggests recent, rapid onset. Other similar cases have been more elderly. A relative had brain fog for six months and then weirdly got better after the so-called booster.
So I think prion disease will happen sometimes, as a fraction of what is probably a whole universe of neurological harms the shots can cause.
I am sorry to hear about your sister. There's so many things that could cause dizziness - including cardiac / blood pressure stuff which is maybe the most common serious AE.
Could the young possible-dementia-sufferer possibly have been a heavy THC user? I've been seeing a lot of very dull witted looking younger people and just figured it was drugs.
My last two years teaching physics at a state university, 2017-2019, I noticed even some majors were heavily drugged.
There wasn't any spacing out in a true sense. More like fully awake but confused and unable to hold onto any thought. Had a lot of other things going on, but the mental aspect made it seem like he wouldn't be out on his own if this was his lifelong state. So I pegged it as a likely recent decline.
Thanks Brian. It's a delicate subject because she knows how I think about the mRNA shots, fine line between trying to help and rubbing it in. She's had workups to see if it's cardio. Awful thing is her four young daughters have all had the shots and two struggled with severe POTS afterward and no one made the connection. Except me, and again, it's a touchy subject.
Sis is in same boat as a lot of shot survivors. No one has any idea what's the matter.
There are two new Seneff papers, one specifically on amyloidogenesis/"prion-like" effects (https://www.authorea.com/doi/full/10.22541/au.166069342.27133443) and another on potential mechanisms did integration of exogenous mRNA into the genome (https://www.authorea.com/doi/full/10.22541/au.166203678.82079667).
Thanks - So, Nothing much new there. Tetz, Tetz, yet again. Improper use of PLAAC.
I wonder if "'prion-like' does not mean prionogenic" will be my new "OAS is not real" campaign. It's interesting that "prion" has some verbal associations with sin; "perversion," "pry," "prey on." Superstition and moral panic isn't immune to sloppy science terminology.
*edit: Ah, the exosomes / vagus nerve part is definitely relevant. "We hypothesize that exosomes released from immune cells in the spleen travel up the vagus nerve to reach the brain stem nuclei, and they deliver their toxic cargo, which can include not only the spike protein but also intact mRNA molecules that encode the protein, to recipient cells in the brain." I might include that in an edit. *edit: It's now in as footnote 12.
There was a Montagnier and Perez paper where they found 26 recent cases of CJD death in France, indicating a much higher rate than the 1 CJD death per year that would be normal. I am having a hard time finding a pdf of the full text of that study now. My original link goes to an empty researchgate page and I neglected to download it. There was an article on TrialSite News written discussing the paper and some other cases of CJD.
https://www.trialsitenews.com/a/is-the-deadly-neurological-condition-creutzfeldt-jakob-disease-linked-to-covid-19-vaccination-2a5eff87
Thank you for that. The information out of France is very interesting. CJD is very rare most of the time and to hear of it at rates like that is disturbing.
Apparently FB deleted the "Died Suddenly News" group (with 300k members) but the owner reinstated it somehow. I checked it this morning. Reports arising of rapid mental decline in elderly vaxxed.
I think from what I've seen of doctors I know, very few will poke into a connection of CJD with the shots. Same for nurses. They prefer to whistle past the graveyard.
MAYBE WE SHOULD HAVE BEEN MORE CONCERNED
https://theagingviking.substack.com/p/maybe-we-should-have-been-more-concerned
On a similar theme although not dealing per se with prions, I would be grateful for a critique of the following :-
https://www.sciencedirect.com/science/article/pii/S027869152200206X
Much of this goes over my head, but I am persevering.
Yeah, that was the follow-up to the first paper as cited above. I don’t know that it adds a lot to the first paper since it focuses on the limited, molecular evidence for innate immune reprogramming. Sure, but, lots of non-mRNA vaccines have been found to reprogram innate immunity (https://unglossed.substack.com/i/71561323/context-non-specific-effects-are-common) so how is this a warning sign for mRNA specifically?
Personally I do think the anecdotes and trends (hello, monkeypox) support innate immune suppression due to these injections, ie some form of VAIDS. But how could they not — just by causing injury and inflammation they will have the same immune suppressive effect as diabetes, for example. So I’m trying to keep is simple as far as worrying about that.
Why would they research it? They’ll just tell everyone it’s “long COVID”. The great mass of NPCs are totally used to that explanation for pretty much everything.
Thanks for all of your research as usual!
Stepping back to the 10,000 foot level: Prion protein is a very small target (considering that prion disease is extremely rare and has not been - to our knowledge - triggered by any of the novel proteins or complex biomolecules to which we have exposed ourselves over the past century, nor does it have any known natural triggers except for misfolded prion proteins from humans and closely-related species), and the virus and vaccine are a rather small gun (with respect to the *number* of novel molecules being introduced into the body).
This makes me *extremely* skeptical of any claims that any of this business will cause prion disease, at least by your mechanism #1 of direct molecular interactions leading to misfolding.
There are hundreds of specific mechanisms by which novel mRNA vaccines could cause immune dysfunction, perhaps thousands of potential molecular interactions by which they could be carcinogenic, quite a few mechanisms by which they could trigger amyloid formation, and comparably very few ways in which they could specifically induce human prion protein to take on a pathogenic conformation.
My own version of Occam's Razor says that if these shots fail in the sense of really messing up a lot of human bodies, it's much more likely to be in an arena that has an abundance of possible failure modes. My top three, so far, are:
1. Amyloid clotting leading to cardiovascular consequences and effectively to premature aging of the cardiovascular system. As this appears to be spike-triggered, it occurs in response to both infection and vaccination (although maybe Omicron spike is less amyloidogenic?).
2. Immune dysfunction, largely arising from the confusing self/non-self signals conveyed by a foreign protein expressed by otherwise healthy cells repeatedly and for long periods. This potentially includes tolerance leading to increased covid susceptibility/severity, autoimmunity, immune suppression, and cancer proliferation (although admittedly there are also potential mechanisms of carcinogenicity that don't involve immune disruption).
3. Disruption of the process by which the virus and the collective human immune system reach evolutionary equilibrium, potentially resulting in enhanced rates of immune escape mutations, emergence of more dangerous variants, and more virus deaths than would otherwise have occurred.
Ah - but regarding “has not been triggered,” none of those precedents exonerates a transfected RNA molecule with G4 motifs! Regarding size, prion protein is being expressed all the time, akin to a housekeeping molecule, though perhaps not in all tissues. Or that was the gist I got of the current understanding. So from a theoretical framework I more envision their being a prion expression “highway” that the mRNA molecule has to cross on its way from LNP/endosome to ribosome. But LNP landing in prion-protein-expressing cells might be rare and the insensitivity to deformed prion protein in isolated cells from a disease standpoint might be quite high. So I’m not super concerned given that I don’t actually see much, if any cognitive decline in the vaxxed IRL.
Agree on 1, though I think the “both infection and vaccination” part will be less accurate in the young. And 2. I think I would keep 3 on the back burner given that I don’t view evolution as driving the story as opposed to continual lab manipulation.
By "size", I mean that there are 20,000 human proteins with which spike, modified mRNA, or lipid nanoparticles could potentially interact in a harmful way. Prion protein is just one of these, and moreover the molecular "key" to misfolding prion protein is presumably rather precise (along the lines of an enzyme-substrate interaction) and the background rate of prion disease is so low that even a 10-fold increase would hardly be catastrophic.
I agree that the abundance of G-quadruplexes in the modified mRNA is concerning, but at the same time G4 motifs are quite common and quadruplexes are probably present in all cells at all times to some degree.
As for 1., yes I would expect most young folks to get far more systemic spike from vaccination than from infection - especially in the Omicron era.
As for 3., the virus is definitely evolving. We have two potential lab releases but also ongoing mutation in both humans and animal reservoirs (e.g. white-tailed deer). Geert Vanden Bossche continues to issue dire warnings about the super-deadly-to-the-vaccinated variant that is sure to appear in the next few months (always in the next few months...) due to a variety of mechanisms involving innate immune suppression, high titers of poorly-neutralizing antibodies masking viral epitopes, and antibody-dependent enhancement. (e.g. https://www.voiceforscienceandsolidarity.org/videos-and-interviews/it-is-5-past-12)
I take it you don't put much stock in his claims? I can't say that I do either, although to the extent that mass vaccination maintains artificially high levels of poorly-matched antibodies and (via ADEI, tolerance, immune suppression, or any other mechanism) appears to lead to higher rates of ongoing population-level infection than would otherwise have occurred, I would expect it to have some influence on the evolutionary trajectory of the virus for good or ill, probably ill.
G4 motifs are common in regulatory genes and untranslated regions but less in coding RNA, so sort of a bride before the wedding deal as far as prion proteins should see. But still, same caveat at the end as before.
3 - I always feel as if vanden Bossche is going to pull some ace out of his sleeve that strengthens his theory. Not after his latest video. The essential problem is everything rests on "the toothless wolves with oven mitt hands will create escape pressure on the deer." No they won't. The genes of deer can't see what doesn't eat them; the genes of SARS-CoV-2 can't see non-neutralizing antibodies. You need to kill to put pressure. This is so fundamental to natural selection and he flaunts it all the time.
His attempt to imply some back-door to that rule with masking / conserved epitope hop-scotch is just intellectual Ponzi-scheme-ism.
Thanks for that. 😂
The best part of waking up...
Thank you - barrels of both Captain and Diet Coca Cola were consumed in the production of the same content. The circle of Captain, like the circle of life, goes on forever.