Regarding the final point, Bedford's team made a plot of clades according to their calculated growth rates to try to show that dN S1 mutations were associated with better growth. The problem here is that the "correlation" totally dies if you take out Delta. Beta and the "other" VOIs, which are my counter-example to the "variants are expl…
Regarding the final point, Bedford's team made a plot of clades according to their calculated growth rates to try to show that dN S1 mutations were associated with better growth. The problem here is that the "correlation" totally dies if you take out Delta. Beta and the "other" VOIs, which are my counter-example to the "variants are explained by fitness" argument, are the blue and gold dots and show very high for dN S1 mutations with no growth advantage in Fig 1b first graph. https://www.biorxiv.org/content/10.1101/2021.09.11.459844v4
Regarding the final point, Bedford's team made a plot of clades according to their calculated growth rates to try to show that dN S1 mutations were associated with better growth. The problem here is that the "correlation" totally dies if you take out Delta. Beta and the "other" VOIs, which are my counter-example to the "variants are explained by fitness" argument, are the blue and gold dots and show very high for dN S1 mutations with no growth advantage in Fig 1b first graph. https://www.biorxiv.org/content/10.1101/2021.09.11.459844v4