In the cmRNA vaccines, Uracil is replaced 100% by Pseudouridine, an alien code, which facilitates the emergence of misfolded proteins (heat shock proteins, isomeric antibodies, dextrorotatory prions/beta sheet prions). cmRNA = chemically modified RNA or modRNA. Misfolded proteins/prions = Wilhelm Reich's T-bacilli.
Interesting post! The relationship between genetic codes and protein really is like a game of decoding the information. There's a reason why this process is called "translation".
A few additional points:
Glycine, by virtue of being the only achiral amino acid, is usually found in regions of proteins where high flexibility is needed. Contrast that with proline, an amino acid where the amine is part of the R-group ring structure, and thus has a fixed conformation. Prolines are found in protein loops and other areas where rigidity is key to the protein. It's the reason why the vaccines have a glycine-proline swap in the spike protein to ideally "lock" the spike protein in an open conformation.
I remember something in my Biochemistry class that suggested that the order of the codons indicates their importance, such that the 1st codon is absolutely pivotal for coding for the proper amino acid while the 3rd provides, as you stated, some wobble room. You can see that looking at the triplet code; the last codon, when swapped for another base, usually translates into an amino acid with similar functionality. However, swapping the first codon is likely to lead to translation for a drastically different amino acid (like a swap from a positively charged one to a negatively charged one).
Just a few additional points. Hopefully the internet comes back wherever you are!!
Why do I read your stuff? Because you say"Proteins are themselves both a language and a structure." And "It should be possible to discuss the logic and coherence of changes to the language in a logical and coherent way; without constant resort to the mathematics of random chance." And "Both proteins and the mRNA ribbons that code for them are physical structures, rather than pure abstraction" Wow, I'm learning. Thanks, professor! Peace
In the cmRNA vaccines, Uracil is replaced 100% by Pseudouridine, an alien code, which facilitates the emergence of misfolded proteins (heat shock proteins, isomeric antibodies, dextrorotatory prions/beta sheet prions). cmRNA = chemically modified RNA or modRNA. Misfolded proteins/prions = Wilhelm Reich's T-bacilli.
Watson-Crick base acid
Interesting post! The relationship between genetic codes and protein really is like a game of decoding the information. There's a reason why this process is called "translation".
A few additional points:
Glycine, by virtue of being the only achiral amino acid, is usually found in regions of proteins where high flexibility is needed. Contrast that with proline, an amino acid where the amine is part of the R-group ring structure, and thus has a fixed conformation. Prolines are found in protein loops and other areas where rigidity is key to the protein. It's the reason why the vaccines have a glycine-proline swap in the spike protein to ideally "lock" the spike protein in an open conformation.
I remember something in my Biochemistry class that suggested that the order of the codons indicates their importance, such that the 1st codon is absolutely pivotal for coding for the proper amino acid while the 3rd provides, as you stated, some wobble room. You can see that looking at the triplet code; the last codon, when swapped for another base, usually translates into an amino acid with similar functionality. However, swapping the first codon is likely to lead to translation for a drastically different amino acid (like a swap from a positively charged one to a negatively charged one).
Just a few additional points. Hopefully the internet comes back wherever you are!!
https://moderndiscontent.substack.com/?r=rgoth
Fascinating, thanks!
High lysine to arginine ratios in the cell seem to prevent and treat viral infections.
Lactoferrin also seems to prevent and treat viral infection. One explanation I recall (but can't find again) is that it involves charged lysine in LF. https://www.sciencedirect.com/science/article/abs/pii/S0022283697913863
The combination lysine:arginine and LF seems to be synergistic, and that is our experience (N=2).
So do high lysine:arginine and LF prevent viral replication in some way, or is there some other mechanism?
I'm very much enjoying your writing. Thank you for your contributions to the on-going conversation.
Why do I read your stuff? Because you say"Proteins are themselves both a language and a structure." And "It should be possible to discuss the logic and coherence of changes to the language in a logical and coherent way; without constant resort to the mathematics of random chance." And "Both proteins and the mRNA ribbons that code for them are physical structures, rather than pure abstraction" Wow, I'm learning. Thanks, professor! Peace
Elegant. You've used your offline time well. Kits are available for doing gene editing at home. That's on my list. Maybe I can make myself smarter.
permutations of 4 choose 3 is 24 not 64.