I would also agree that the presence of giant cells indicates a system wide inflammatory process. Similar to that seen in strep M protein induced carditis. As far as I can recall, the epidemiology of strep induced cross reactivity to heart myosin is seen primarily in the young. Curiously I did a brief stent in such a lab years ago. The PI had worked on this project for decades and yet still didn’t have a complete model for pathophysiology. That has been my biggest objection since the start of this situation. Akin to people turning to diet pills for a quick fix the scientific community has hurried all dictums. This isn’t science at all. It takes, sometimes, numerous lifetimes to find and characterize a signal.
Now from the other side, working in a pediatric ER, I can tell you, no one inquires about vax status in a teenager presenting with chest pain. It’s not even on the radar.
I can perceive the limits of medical understanding of myocarditis, but it's still beyond my own understanding, so I can't really play ball in the debate. The July paper by Bozkurt suggesting a generic, pre-primed autoimmune condition still strikes me as fantasy-weaving. At best, pre-existing anti-self antibodies that are elevated after the shots, just like anti-syncyctin-1 (since 1-3 days isn't enough time for a novel antibody response)? But antibodies don't attack cells randomly, so the disproportionate impact on younger men doesn't seem to be a signal for auto-antibodies one way or the other.
In general I would bet that medicine never really "figures out" the heart to any extent that somehow adds value to "exercise = good," and I have no interest in letting them ever try to mess around with mine. But personal preferences aside, if someone is a subject in a medical experiment, someone else should be looking at their vitals.
I would also agree that the presence of giant cells indicates a system wide inflammatory process. Similar to that seen in strep M protein induced carditis. As far as I can recall, the epidemiology of strep induced cross reactivity to heart myosin is seen primarily in the young. Curiously I did a brief stent in such a lab years ago. The PI had worked on this project for decades and yet still didn’t have a complete model for pathophysiology. That has been my biggest objection since the start of this situation. Akin to people turning to diet pills for a quick fix the scientific community has hurried all dictums. This isn’t science at all. It takes, sometimes, numerous lifetimes to find and characterize a signal.
Now from the other side, working in a pediatric ER, I can tell you, no one inquires about vax status in a teenager presenting with chest pain. It’s not even on the radar.
I can perceive the limits of medical understanding of myocarditis, but it's still beyond my own understanding, so I can't really play ball in the debate. The July paper by Bozkurt suggesting a generic, pre-primed autoimmune condition still strikes me as fantasy-weaving. At best, pre-existing anti-self antibodies that are elevated after the shots, just like anti-syncyctin-1 (since 1-3 days isn't enough time for a novel antibody response)? But antibodies don't attack cells randomly, so the disproportionate impact on younger men doesn't seem to be a signal for auto-antibodies one way or the other.
In general I would bet that medicine never really "figures out" the heart to any extent that somehow adds value to "exercise = good," and I have no interest in letting them ever try to mess around with mine. But personal preferences aside, if someone is a subject in a medical experiment, someone else should be looking at their vitals.