Echoing Bird, the fusion happens both when the virus infects cells and after / while the virus is in an infected cell. A lot of viruses with functional fusion glycoproteins do this, including the one named after the effect (RSV).
OK, but what it sounds like you are saying is that the infected cell has made spike proteins and they have migrated to the surface of the cell in preparation for budding but they then fuse to neighboring cells before the virion gets a chance to bud. Is that the case? Will RNA get transferred to the neighboring cell and infect it all over again?
In addition, I can imagine that a SARS-CoV-2 virion that has fused to a cell might then fuse to a neighboring cell if it's spike contacts the correct receptor but the RNA is gone at that point, so does that count as infecting the neighboring cell?
This is known in HIV evasion of the immune system. Fusion to a neighboring cell is triggered. Thus the infected cell joins a non-infected cell, and now you have 2 infected cells connected as 1 bigger mass.
Brian, I had to let you know that Omicron does in fact evade SARS-1 immunity. Ask me how I know and I'll see if I can explain with this headache and brain fog. With that, it was fairly mild. My wife is having a tougher time. I had SARS-1, wife stopped at 2 jabs.
Brian - Seriously, God bless you. You are doing such incredibly important work, laying out the biochemical architecture of what is happening on earth in similar fashion to Katherine Watt revealing the legal architecture. I do not fully understand all your analysis. But I understand enough to see how true your aim is and how committed you are to both accuracy and precision. Please know you are deeply appreciated.
So as mentioned in the SARS-COV1 study Sotrovimab was a monoclonal antibody that was isolated from someone previously infected with SARS-COV1. It was effective until Ba.2, likely from the T376A, D405N, and R408S group of mutations. These amino acids aren't on the surface, and so I believe it's assumed that these mutations led to a different folding pattern in the spike that shielded Sortrovimab's epitopes and stopped it from binding.
Interesting - same potential effect if we're lucking enough for someone to follow up showing a difference in pre-exposure phagocytosis assay results etc.!
I don't understand this statement:
"Fusion allows the virus to spread from cell to cell without leaving the cell."
I thought that once a virus fused to a cell it effectively became part of the cell and injected its genetic payload into the cytosol .
Echoing Bird, the fusion happens both when the virus infects cells and after / while the virus is in an infected cell. A lot of viruses with functional fusion glycoproteins do this, including the one named after the effect (RSV).
OK, but what it sounds like you are saying is that the infected cell has made spike proteins and they have migrated to the surface of the cell in preparation for budding but they then fuse to neighboring cells before the virion gets a chance to bud. Is that the case? Will RNA get transferred to the neighboring cell and infect it all over again?
In addition, I can imagine that a SARS-CoV-2 virion that has fused to a cell might then fuse to a neighboring cell if it's spike contacts the correct receptor but the RNA is gone at that point, so does that count as infecting the neighboring cell?
This is known in HIV evasion of the immune system. Fusion to a neighboring cell is triggered. Thus the infected cell joins a non-infected cell, and now you have 2 infected cells connected as 1 bigger mass.
Brian, I had to let you know that Omicron does in fact evade SARS-1 immunity. Ask me how I know and I'll see if I can explain with this headache and brain fog. With that, it was fairly mild. My wife is having a tougher time. I had SARS-1, wife stopped at 2 jabs.
I am sorry to hear about the brain fog! Mine was two days. I hope your wife’s tougher time also reverses.
It is resolving and thanks.
Brian - Seriously, God bless you. You are doing such incredibly important work, laying out the biochemical architecture of what is happening on earth in similar fashion to Katherine Watt revealing the legal architecture. I do not fully understand all your analysis. But I understand enough to see how true your aim is and how committed you are to both accuracy and precision. Please know you are deeply appreciated.
Thank you! Appreciate the appreciation of accuracy and precision, I will keep placing those Preview App arrows *just so*.
So as mentioned in the SARS-COV1 study Sotrovimab was a monoclonal antibody that was isolated from someone previously infected with SARS-COV1. It was effective until Ba.2, likely from the T376A, D405N, and R408S group of mutations. These amino acids aren't on the surface, and so I believe it's assumed that these mutations led to a different folding pattern in the spike that shielded Sortrovimab's epitopes and stopped it from binding.
Interesting - same potential effect if we're lucking enough for someone to follow up showing a difference in pre-exposure phagocytosis assay results etc.!
There is no “Omicron” because Covid is completely FAKE and virology is pure junk fake science.
What do you think about the spherical Earth theory?
How DARE you on my quinceañera!