IgG4 surges, and lab-apparent T Cell targeting of infected cells declines following a 3rd Dose of the Pfizer/BioNTech Covid vaccine, in a new study from Bavaria.
And one more article about IgG4 ...
High Immunoglobulin G2 (IgG2) and Low IgG4 Levels Are Associated with Human Resistance to Plasmodium falciparum Malaria
Will we see an upsurge in malaria in populations vaccinated with the modRNA Gene Therapy?
Another thought. Is the IgG4 class switching causing a rise in shingles? I have heard of several vaccinated people who had a shingles attack some time after the Vax and boosters. It seems possible that the Fc-Fc binding action of IgG4 Abs for any antigen could reduce your body's control over the Varicella Zoster Virus allegedly lurking in your "cranial nerve ganglia, dorsal root ganglia and autonomic ganglia along the entire neuraxis."
This is a generic article on Shingles.
And now comes:
Reduced effectiveness of repeat influenza vaccination: distinguishing among within-season waning, recent clinical infection, and subclinical infection
Is this another instance of IgG4 class switching. I don't think they investigated that deeply ... but would be my suspicion.
In looking up class switching in Wikipedia, I found this page: https://en.wikipedia.org/wiki/Immunoglobulin_class_switching
It claims that class switching is actually more complex than I thought and the actual trajectory is:
1. μ - IgM
2. δ - IgD
3. γ3 - IgG3
4. γ1 - IgG1
5. α1 - IgA1
6. γ2 - IgG2
7. γ4 - IgG4
8. ε - IgE
9. α2 - IgA2
Is this correct? If so, it would seem that continual boosting should eventually result in elevated IgA2 levels.
And a review article from 2023 on IgG4 and its involvement in disease:
As well as some papers on IgG4 Related Disease: https://www.zotero.org/foxsayswhat/collections/3BX8S5UL/items/C4A2WKL5/item-list
And another paper from May 2023 looking at IgG class switching in primates (macaques) after multiple doses:
80.7% IgG4 after four doses?
In addition, it is worth reading Dr David Grime's article on D3 and the impact of vaccinations etc:
We are seeing claims of turbo cancers occurring after the #ClotShot.
Perhaps there is synergy between the IgG class switching and the D3 (strictly, calcitriol) depleting effect of vaccinations.
In this paper about immune evasion by SARS-CoV-2 etc https://www.nature.com/articles/s12276-021-00602-1, I found this interesting statement:
"ORF3a localizes to the plasma membrane of the ER and Golgi and induces ER stress by activating the PKR-like ER kinase (PERK) pathway. The activated PERK pathway can induce the phosphorylation and cause the degradation of IFNAR188, evading host antiviral IFN programs (Fig. 3). In addition, ORF3a also regulates apoptotic pathways. Recent studies have shown that ORF3a of SARS-CoV and SARS-CoV-2 can trigger host cell apoptosis by inducing caspase activation or Golgi fragmentation89,90, indicating that ORF3a targets multiple cellular pathways to hamper host antiviral responses."
Why would a virus want to cause apoptosis of its host cell? Are they altruistic? Doing it for the greater good of Virushood?
How long would the IgG4 last? If people are not subjecting themselves to repeated shots of the modRNA Gene Therapy will all the B-cells generating IgG4 antibodies eventually die out?
And a list of more than 100 IgG4 related disease etc papers:
The effects of IgG4 have been known about since 2013:
IgG4 subclass antibodies impair antitumor immunity in melanoma
"It has been shown that laboratory animals passively infused with human total IgG or IgG4 develop signs in 5 of these 13 disorders, proving the pathogenicity of this antibody. IgG4-induced autoimmunity is suggested by the finding that the majority of antigen-specific autoantibodies are of the IgG4 class and that their concentrations correlate with the seriousness of the sickness for the eight remaining disorders ."
From the most recent paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222767/
Great diagrams, including Fc-Fc binding and its effect.
They also refer to Irrgang et al in the discussion ... and, as I pointed out in another comment this has been known about for some time ... but a careful read of the above paper reveals many gems that are not mentioned in the title. That includes the Pertussis vaccine. I am shocked that the paper passed peer review. Maybe it didn't.
I looked at Dutch sewage water the other day. Not the water itself, but data representing the RNA flow.
I should have used some other measure instead of cases, since this is obviously affected by testing efforts, but I think this effect might still exist if I had done that.
Any suggestions how to handle this? Seropositivity? Some other combination of variables to represent how many people are currently infected?
2 years into this covid clown theatre i think the whole scam was and still is a big success with all these people dying, because we are suppose to die with this treatment keeping THEM, the psycho designers happy with their killer treatment plan (didn't prune face gates had a slip of the tongue when stating it is the final solution...?) ... now we are constantly suffering from even the normal colds and flues... they are at a constant jabbering lies and keep piling up their lies by the buckets full to their gullable vaccine junkies who by now have a psychological dependency either on their gov states health depts or hailing gates, bourla and those freaks as their own personal wall heroes. Like a puppy shows love and adoration for his owner... sickening.
I remember you writing about tolerance so long ago!
IGg3 to IGg4 conversion. How long has this been going on?
1918 H1N1 looks very much like 1977 & 2009 Russian and Swine Flu.
Tuskegee 1930 Syphilis shots into black people
1952 Polio Shots
1954 SV40 found in Polio shots
1960 Non-Hodgkins Lymphoma cancer
1968 Asian flu
1976 Swine Flu
1976 Hepatitis shots into homosexuals
1980 outbreak of HIV
1986 new vaccine protocols for children
1987 AZT for HIV
1990 Autism epidemic
2009 Swine Flu
Non-Hodgkin Lymphoma = IGg4 Lymphadenopathy
When are going to start connecting the dots?
This is FANTASTIC! How am I only finding this today?