IgG4 surges, and lab-apparent T Cell targeting of infected cells declines following a 3rd Dose of the Pfizer/BioNTech Covid vaccine, in a new study from Bavaria.
Another thought. Is the IgG4 class switching causing a rise in shingles? I have heard of several vaccinated people who had a shingles attack some time after the Vax and boosters. It seems possible that the Fc-Fc binding action of IgG4 Abs for any antigen could reduce your body's control over the Varicella Zoster Virus allegedly lurking in your "cranial nerve ganglia, dorsal root ganglia and autonomic ganglia along the entire neuraxis."
No one is very precise about the overlay of genetic syntax and IgG/A/E divisions, so I just stick with an intuitive interpretation that there is no linear mixture. I treat it as B Cells start with M, and after M or D, get on one "track" - IgG, IgE, or IgA, and then progress to the end of that track.
"ORF3a localizes to the plasma membrane of the ER and Golgi and induces ER stress by activating the PKR-like ER kinase (PERK) pathway. The activated PERK pathway can induce the phosphorylation and cause the degradation of IFNAR188, evading host antiviral IFN programs (Fig. 3). In addition, ORF3a also regulates apoptotic pathways. Recent studies have shown that ORF3a of SARS-CoV and SARS-CoV-2 can trigger host cell apoptosis by inducing caspase activation or Golgi fragmentation89,90, indicating that ORF3a targets multiple cellular pathways to hamper host antiviral responses."
Why would a virus want to cause apoptosis of its host cell? Are they altruistic? Doing it for the greater good of Virushood?
How long would the IgG4 last? If people are not subjecting themselves to repeated shots of the modRNA Gene Therapy will all the B-cells generating IgG4 antibodies eventually die out?
B Cells scale based on antigen (the spike protein) exposure (dose) and antigenicity (how interesting is this protein to the immune system), so this is the whole idea of vaccine "strategy" because to achieve high baseline antibodies is not always easy, maybe the thing you want antibodies against isn't very antigenic so you need a lot of doses, but then you get into tolerance territory, this is the problem with HIV. But this is actually usually stupid because B Cells expand (divide into plasma cells that pump out antibodies) when an antigen is encountered again, kicking out more antibodies. But when not expanding, they don't go away. They can remodel (renter germinal centers to make adjustments to antibody design), or new B Cells can join the pool that refers to the same antigen, and in the case of the spike protein as I have covered in studies looking at this question, it is almost entirely the former that is taking place, not the latter. So the spike-referring B Cell pool that is converting to IgG4 isn't going anywhere, it can only keep becoming more and more IgG4-biased. It can un-expand to lower baseline levels but this doesn't matter because it will expand when spike protein comes around, same composition of IgG phenotype as before.
Measles virus infection can clear out B Cells but everyone is vaccinated (or naturally immune for some older people), so that's not an option.
What causes the switching? I understand that the switching is caused by some sort of gene editing in the responsible genes, but wouldn't a fresh batch of those things right out of Hematapoietic stem cell school start from scratch?
"It has been shown that laboratory animals passively infused with human total IgG or IgG4 develop signs in 5 of these 13 disorders, proving the pathogenicity of this antibody. IgG4-induced autoimmunity is suggested by the finding that the majority of antigen-specific autoantibodies are of the IgG4 class and that their concentrations correlate with the seriousness of the sickness for the eight remaining disorders [46]."
Great diagrams, including Fc-Fc binding and its effect.
They also refer to Irrgang et al in the discussion ... and, as I pointed out in another comment this has been known about for some time ... but a careful read of the above paper reveals many gems that are not mentioned in the title. That includes the Pertussis vaccine. I am shocked that the paper passed peer review. Maybe it didn't.
I should have used some other measure instead of cases, since this is obviously affected by testing efforts, but I think this effect might still exist if I had done that.
Any suggestions how to handle this? Seropositivity? Some other combination of variables to represent how many people are currently infected?
2 years into this covid clown theatre i think the whole scam was and still is a big success with all these people dying, because we are suppose to die with this treatment keeping THEM, the psycho designers happy with their killer treatment plan (didn't prune face gates had a slip of the tongue when stating it is the final solution...?) ... now we are constantly suffering from even the normal colds and flues... they are at a constant jabbering lies and keep piling up their lies by the buckets full to their gullable vaccine junkies who by now have a psychological dependency either on their gov states health depts or hailing gates, bourla and those freaks as their own personal wall heroes. Like a puppy shows love and adoration for his owner... sickening.
...and people aren't noticing because - "we get old" "shit happens" and it's not getting connected to the shots.
Example: friend of mine presents with mesothelioma. It is required to be exposed to asbestos in order to get this cancer. She was exposed in childhood, as many Australian homes were made with "fibro" - asbestos. However, her immune system can no longer fight the mesothelioma and it is now presenting as a full-on case like the miners get. But she looks at that fibro house in childhood - not the shots deleting her ability to battle the bad cells. (at least 3, likely 4 shots)
And one more article about IgG4 ...
High Immunoglobulin G2 (IgG2) and Low IgG4 Levels Are Associated with Human Resistance to Plasmodium falciparum Malaria
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC97275/
Will we see an upsurge in malaria in populations vaccinated with the modRNA Gene Therapy?
Another thought. Is the IgG4 class switching causing a rise in shingles? I have heard of several vaccinated people who had a shingles attack some time after the Vax and boosters. It seems possible that the Fc-Fc binding action of IgG4 Abs for any antigen could reduce your body's control over the Varicella Zoster Virus allegedly lurking in your "cranial nerve ganglia, dorsal root ganglia and autonomic ganglia along the entire neuraxis."
This is a generic article on Shingles.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176736/
And now comes:
Reduced effectiveness of repeat influenza vaccination: distinguishing among within-season waning, recent clinical infection, and subclinical infection
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071822/
Is this another instance of IgG4 class switching. I don't think they investigated that deeply ... but would be my suspicion.
In looking up class switching in Wikipedia, I found this page: https://en.wikipedia.org/wiki/Immunoglobulin_class_switching
It claims that class switching is actually more complex than I thought and the actual trajectory is:
1. μ - IgM
2. δ - IgD
3. γ3 - IgG3
4. γ1 - IgG1
5. α1 - IgA1
6. γ2 - IgG2
7. γ4 - IgG4
8. ε - IgE
9. α2 - IgA2[4]
Is this correct? If so, it would seem that continual boosting should eventually result in elevated IgA2 levels.
No one is very precise about the overlay of genetic syntax and IgG/A/E divisions, so I just stick with an intuitive interpretation that there is no linear mixture. I treat it as B Cells start with M, and after M or D, get on one "track" - IgG, IgE, or IgA, and then progress to the end of that track.
And a review article from 2023 on IgG4 and its involvement in disease:
https://www.nature.com/articles/s41577-023-00871-z#Abs1
As well as some papers on IgG4 Related Disease: https://www.zotero.org/foxsayswhat/collections/3BX8S5UL/items/C4A2WKL5/item-list
And another paper from May 2023 looking at IgG class switching in primates (macaques) after multiple doses:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451060/
80.7% IgG4 after four doses?
In addition, it is worth reading Dr David Grime's article on D3 and the impact of vaccinations etc:
http://www.drdavidgrimes.com/2021/11/covid-19-vitamin-d-urgent-vaccines-need.html
We are seeing claims of turbo cancers occurring after the #ClotShot.
Perhaps there is synergy between the IgG class switching and the D3 (strictly, calcitriol) depleting effect of vaccinations.
In this paper about immune evasion by SARS-CoV-2 etc https://www.nature.com/articles/s12276-021-00602-1, I found this interesting statement:
"ORF3a localizes to the plasma membrane of the ER and Golgi and induces ER stress by activating the PKR-like ER kinase (PERK) pathway. The activated PERK pathway can induce the phosphorylation and cause the degradation of IFNAR188, evading host antiviral IFN programs (Fig. 3). In addition, ORF3a also regulates apoptotic pathways. Recent studies have shown that ORF3a of SARS-CoV and SARS-CoV-2 can trigger host cell apoptosis by inducing caspase activation or Golgi fragmentation89,90, indicating that ORF3a targets multiple cellular pathways to hamper host antiviral responses."
Why would a virus want to cause apoptosis of its host cell? Are they altruistic? Doing it for the greater good of Virushood?
How long would the IgG4 last? If people are not subjecting themselves to repeated shots of the modRNA Gene Therapy will all the B-cells generating IgG4 antibodies eventually die out?
B Cells scale based on antigen (the spike protein) exposure (dose) and antigenicity (how interesting is this protein to the immune system), so this is the whole idea of vaccine "strategy" because to achieve high baseline antibodies is not always easy, maybe the thing you want antibodies against isn't very antigenic so you need a lot of doses, but then you get into tolerance territory, this is the problem with HIV. But this is actually usually stupid because B Cells expand (divide into plasma cells that pump out antibodies) when an antigen is encountered again, kicking out more antibodies. But when not expanding, they don't go away. They can remodel (renter germinal centers to make adjustments to antibody design), or new B Cells can join the pool that refers to the same antigen, and in the case of the spike protein as I have covered in studies looking at this question, it is almost entirely the former that is taking place, not the latter. So the spike-referring B Cell pool that is converting to IgG4 isn't going anywhere, it can only keep becoming more and more IgG4-biased. It can un-expand to lower baseline levels but this doesn't matter because it will expand when spike protein comes around, same composition of IgG phenotype as before.
Measles virus infection can clear out B Cells but everyone is vaccinated (or naturally immune for some older people), so that's not an option.
What causes the switching? I understand that the switching is caused by some sort of gene editing in the responsible genes, but wouldn't a fresh batch of those things right out of Hematapoietic stem cell school start from scratch?
And a list of more than 100 IgG4 related disease etc papers:
https://www.zotero.org/foxsayswhat/collections/3BX8S5UL/items/C4A2WKL5/item-list
The effects of IgG4 have been known about since 2013:
https://pubmed.ncbi.nlm.nih.gov/23454746/
IgG4 subclass antibodies impair antitumor immunity in melanoma
"It has been shown that laboratory animals passively infused with human total IgG or IgG4 develop signs in 5 of these 13 disorders, proving the pathogenicity of this antibody. IgG4-induced autoimmunity is suggested by the finding that the majority of antigen-specific autoantibodies are of the IgG4 class and that their concentrations correlate with the seriousness of the sickness for the eight remaining disorders [46]."
From the most recent paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222767/
Great diagrams, including Fc-Fc binding and its effect.
They also refer to Irrgang et al in the discussion ... and, as I pointed out in another comment this has been known about for some time ... but a careful read of the above paper reveals many gems that are not mentioned in the title. That includes the Pertussis vaccine. I am shocked that the paper passed peer review. Maybe it didn't.
I looked at Dutch sewage water the other day. Not the water itself, but data representing the RNA flow.
https://substack.pervaers.com/misc/Dutch_sewage_per_case.png
https://substack.pervaers.com/misc/Dutch_cases.png
https://substack.pervaers.com/misc/Dutch_sewage.png
I should have used some other measure instead of cases, since this is obviously affected by testing efforts, but I think this effect might still exist if I had done that.
Any suggestions how to handle this? Seropositivity? Some other combination of variables to represent how many people are currently infected?
2 years into this covid clown theatre i think the whole scam was and still is a big success with all these people dying, because we are suppose to die with this treatment keeping THEM, the psycho designers happy with their killer treatment plan (didn't prune face gates had a slip of the tongue when stating it is the final solution...?) ... now we are constantly suffering from even the normal colds and flues... they are at a constant jabbering lies and keep piling up their lies by the buckets full to their gullable vaccine junkies who by now have a psychological dependency either on their gov states health depts or hailing gates, bourla and those freaks as their own personal wall heroes. Like a puppy shows love and adoration for his owner... sickening.
...and people aren't noticing because - "we get old" "shit happens" and it's not getting connected to the shots.
Example: friend of mine presents with mesothelioma. It is required to be exposed to asbestos in order to get this cancer. She was exposed in childhood, as many Australian homes were made with "fibro" - asbestos. However, her immune system can no longer fight the mesothelioma and it is now presenting as a full-on case like the miners get. But she looks at that fibro house in childhood - not the shots deleting her ability to battle the bad cells. (at least 3, likely 4 shots)
I remember you writing about tolerance so long ago!
IGg3 to IGg4 conversion. How long has this been going on?
1918 H1N1 looks very much like 1977 & 2009 Russian and Swine Flu.
Tuskegee 1930 Syphilis shots into black people
1952 Polio Shots
1954 SV40 found in Polio shots
1960 Non-Hodgkins Lymphoma cancer
1968 Asian flu
1976 Swine Flu
1976 Hepatitis shots into homosexuals
1980 outbreak of HIV
1986 new vaccine protocols for children
1987 AZT for HIV
1990 Autism epidemic
2009 Swine Flu
2002 SARS-Cov-1
2006 MERS
2019 SARS-Cov-2
Non-Hodgkin Lymphoma = IGg4 Lymphadenopathy
When are going to start connecting the dots?
This is FANTASTIC! How am I only finding this today?