A semi-experimental post format, to spice up day 2 of the March Donation Drive! Let’s see if these 9 months of research into immunology, microbiology, and genetics are good for more than just one-way reporting and opining. Ask whatever burning biology/virus/vaccine-related questions are stuck at the back of your mind.
Wow I was actually thinking of doing the same! It feels like there are many people who would also appreciate this format! Also, I'll let you know that even if you have no formal experience the yearning to learn and the actual research you do means a lot more than having a degree as validation for one's role as an authority figure in science! Don't sell yourself short because a paper has not dictated your scientific worth.
As for questions I'll return to this post later and see what I can come up with! I think my brain is already burned out from proper thinking...
For legal purposes, I must acknowledge that the self-deprecation does not come with a "100% sincerity" guarantee, haha. Being asked a question I have to research is always a very productive prompt, anyway. I used to find such questions in bigger comment threads but most comment threads are just about the social/political aspect of "the pandemic" at this point in time, biology is out of season.
Autoimmune diseases are uniquely 'first world' issues (or so I have heard). Some research has been done using intestinal worms as a treatment. Something like a bored immune system that has nothing else to do so...Anyway it has only been a hundred years or so since every human being on the planet had intestinal worms. Now in western society it would be horrifying to consider the prospect but maybe we should. C-diff has become an almost incurable problem using conventional antibiotics ect but a rectal infusion of fresh stool almost always works and is gaining traction. This two year journey has facilitated a fresh look at many things in this world. I have gone from being a covid vaccine sceptic to a full on 'conspiracy theorist' rejecting almost every assumption I have incorporated into my 70 year old brain. I appreciate the part you are playing in this challenge. Do you have any ideas about the larger parasites and the role they may play in keeping our immune system healthy?
The Helminth question is an interesting one. It would seem to predict that the allergy and autoimmunity explosion should have kicked in around 1900, the same time that the hygiene-obsessed upper class started having problems with polio. Or maybe even earlier, when humans started to live near the arctic circle. As a side note I grew up partially in Bermuda where it was normal to see roundworm bumps in kids’ feet - but I never got any bumps, so it wasn’t actually universal. Still I think there’s probably something to it.
But it seems more obvious to look to measles vaccination as the culprit. Measles exposure was truly ubiquitous, and infection targets immune cells and has a years-long immune suppression effect that may help other bugs take up residence in early childhood, and the historical timing fits pretty well with when all our other problems started emerging (allowing for a lag as the first generation of vaxxed kids had to become teens and adults). Though I’m still only just beginning to look into it.
Many bacterial infections (depending on location) could be better described as “monoculture disorder” or microbiome disruption, so it makes sense that transplanting a whole intact microbiome is easier than trying to regrow one from scratch (when biofilms that survive antibiotics give the monoculture strain a head start).
I am very precariously perched in Baja California. It's a relief to be somewhere where the government cannot control the economy enough to put in any real mandates, but uncomfortable being next to California where new mandates are always around the corner.
I have spent the last year looking for somewhere to move...sell my very inflated $ house and pay cash for something else in a "safer" place. Boise is a great place to live but is subject to federal mandates and being a college town very liberal mayor. The whole of Idaho is conservative but dramatic influx of people from Washington and Oregon (and California) threatens to bring the same values that have destroyed those states. Mandates on the west coast were/are egregious as you know. I have concluded that there is no escape. Grew up in Anaheim, half my adult life in Seattle, which at the time was beautiful, and now 25 years in Idaho. We all seem to live in a climate where irrational fear dominated our lives for two years. We are distracted at the moment (rational fear) by the tsunami of hysterical and like minded politicians and media rolling over Ukraine and which looks very much like the like the last one. I suspect that most governments have tasted authoritarianism and find it delicious.
Since I did not insert those segments, I can only speculate. Randomly slapping on epitopes from other proteins can only really accomplish three things: Replicate a toxic peptide, attempt to induce an anti-epitope antibody response, or leave a human signature for its own sake.
But the big things that contribute to a unique bug/host phenotype, like "acquire this tropism (tissue preference)" or "acquire this immune-evading/suppressing/modulating trait" are either spread out over multiple non-consecutive residues or are in the parts of the virus you can't swap out without breaking (like the highly conserved RdRp protein).
So back to the three things you could do. As far as 1, maybe the NTD-located inserts are contributing to microclotting, since HIV proteins are also associated with microclotting in Pretorius's research (https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0038-1676374 ) - but regular coronavirus spike might be just as toxic in this regard. As for 2, well sure, maybe Baric and Fauci built this as a chimeric "live HIV vaccine" 20 years ago, noticed it caused ARDS and became more interested in it as a "second HIV" (as in phony super-virus) and have just been working on the staging of a worldwide release since then. Who knows. As for 3, the inserts could have just been inserted to make the virus seem scarier than it is, nothing more than eyes on a butterfly's wings.
Note that the HIV virus doesn't seem like a more aggressive immune-system-attacker than measles or other common viruses, and the "causes AIDS" theory has always been very smelly.
My main thought whenever it comes to autoimmune sensitization is that it is always a two-part etiology, not just sensitization but failure of T Cell negative selection or perhaps gut-microbiome-mediated tolerance. It additionally seems to predict that autoimmunity, like allergies, should be reversible, again through microbiome-mediated induction of tolerance. And indeed we see this to be the case with some acute autoimmune diseases like GBS or acute tubulointerstitial nephritis. So I'm not sure autoimmunity is a natural fit for autism, even if autoimmunity (esp. with repeated sensitizations) would explain it, given that it suggests reversibility.
T cell negative selection occurs for high affinity self reactive cells. When the T cell receptor recognizes a peptide that even differs by one amino acid residue from a self-peptide, it can be positively selected. We call these low-affinity self reactive (LASR) T cells. These are necessary to fight cancer. Basically, you need T cells that are able detect peptides that are slightly different from self (cancer). These T cells however still cross react with self and can result in autoimmunity.
This is the reason we have paraneoplastic autoimmunity.
Right, tolerance is a two part barrier against autoimmunity which implies that neither is absolute. And yet it usually works anyway which implies that being absolute is not required in order for it to be an equally powerful mechanism as sensitization. Healthy people probably have long lived plasma cells kicking out all kinds of auto-antibodies all the time, implying prior self-sensitization, but they are protected by tolerance.
So by that same note I am skeptical that autoimmunity is the cause rather than effect of T1D, and I’ve made my own allergies go away by increasing outdoor exposure. So I think even a really plausible sensitization mechanism, such as injected homologous proteins, asks for a defense against the tolerance attack.
Have you ever looked into the childhood vaccines? The Simpsonwood transcript regarding mercury? The 'debate' letters between ICAN and HHS? Consequences of aluminum? Potential connection to autism and other autoimmune issues in children?
It's a big part of my research, but there's also a galaxy of poorly-documented history to struggle with. For example I don't consider the polio portion of Dissolving Illusions to be anything like a satisfactory examination of the millions of mysterious events in question.
That said, I regard the entire concept of vaccination as essentially pseudo-science. We know there's more to immunity than antibodies, so presuming that "preventing infection," especially by forcing the immune system to produce antibodies with alum, is intrinsically a net benefit compared to letting kids get naturally infected, is not supported by anything in the last 6 decades of research. It turned out our gut doesn't work right without bacteria. There's no reason not to assume our nervous system and immune systems don't work right without childhood chickenpox and measles invasion, respectively. Put differently, "In 1799 we didn't even know what the immune system is and yet we mastered it," doesn't pass the smell test at all.
I also wonder about the compount effect of all the different vaxes an individual gets (and other influences). I have the impression that these things are usually studied with tunnel view, isolated. And it seems to be only interesting for some reason if a product "works" according narrow to definition, but other effects and longterm, overall quality of life impact seems not to be looked at by anyone. Certainly not the developers of such products.
Paul Thomas has a good take on the toxicity of excess aluminum in the CDC infant vaccine schedule.
Stephanie Seneff "Toxic Legacy" reviews the cellular damage from glyphosate (Roundup.)
When we can't identify a cause for a particular condition, we wave our arms and declare it "multifactorial", which is likely true and a good substitute for a shrug of the shoulders and admission of ignorance.
The progress of analytical chemical tools and computing power over the past few decades makes structural determination and reactions somewhat accessible. The complexity is still a limitation to being able to determine exact causes.
For an example, have a look at the various mechanisms proposed for ivermectin's activity against Covid.
Mandates and pharma marketing have made it impossible to look at overall anything. Which is exactly what you want if propping up a psuedo-science. Everything about child vaccination after the 80s can be explained by profiteering, everything before the 70s can be explained as the last gasps of the "let's conquer this gross, useless Nature thing" attitude that led to the Scientific Method to begin with. Neither one of these admits *any* possible plus to natural infection, so there's no need to prove that preventing natural infection is a net benefit.
The “probably not” prediction in 2021 was like loading all of humanity into an experimental rocket and saying “It blew up in all the test runs, but never in a real-world use.” My prediction was ADE would be an issue coming up a year or two from now, after more antigenic drift.
Omicron (BA.1 and BA.2) is like fast-forwarding 20 years and seems to have rendered the ADE question moot. Maybe if Omicron had retained the same tissue tropism and fusion capability, it would have been a problem, but now that there’s been plenty of natural infection I don’t think we have to worry even if those qualities come back. So, score one for the hubristic vaccine hawks here.
At this point I’m inclined to think my earlier prediction was off to begin with, and a valid prediction would have been that the vaccines would have produced immediately observable ADE as with previous RSV vaccine trials. Likewise, the RSV-“ADE” mechanism is the only one that probably would have been applicable to SARS-CoV-2. This mechanism shouldn’t really be described as “ADE” but just simple allergic sensitization that leads to excessive inflammation and pneumonia. Whereas ADE is still a valid term for Dengue and maybe the failed Measles vaxxes. A good overview of all the differences is provided by the “dark side” at https://www.chop.edu/centers-programs/vaccine-education-center/vaccine-safety/antibody-dependent-enhancement-and-vaccines
There’s one last possibility which is that Covid vaccine ADE is disguised by pre-priming of some sort, given that “Covid” itself involves an RSV-ADE like inflammatory reaction. So there’s no way to tell that the vax primes ADE since the control group (some of the unvaxxed) is also primed to begin with. Could this priming be the flu vaccines? The evidence isn’t strong but it’s an interesting possibility.
Was that a GvB claim? I know that "Radagast" made a big splash by extrapolating from the innate immune suppression study to suggest that severe efficacy is a result of depressing the inflammatory response, which I think is going a bit too far with a limited study that had no control group (https://www.rintrah.nl/suppression-of-the-innate-immune-system-the-main-cause-of-the-pandemic-of-the-fully-vaccinated/). But GvB certainly excels at crafting counter-intuitive claims as well, haha.
But why not the same in Israel, the Northeast US, etc? Or perhaps the anecdotes of skin cancers, but these seem more acute than "AIDS redux," suggesting for now that if immune suppression is involved it might be only temporary.
At the same time, there's no need to overthink things too much or look for proof of "altered innate immunity." If the transfections are causing physical harm, this alone would disrupt and depress immunity. Everything is interconnected.
I'm ambivalent on the circuitry evidence. One thing to bear in mind is that DNA/RNA already are "self-assembling" molecules, essentially strings of wobbly self-attracting bits. And lipids form barriers against aqueous solution. So just the RNA plus lipids could explain the interesting sharp lines and negative space in slides, for all we know! The big difference would be that the vials contain multiple LNPs that can bump into each other and accidentally combine, increasing the attraction potential and setting off a chain reaction, who knows. Whereas once injected into the body, they are less likely to self-collide, and quickly get other proteins stuck to them anyway. This is also probably why viruses like to insert other proteins both into the curls of their RNA and studded throughout their membranes, so they don't accidentally glue to each other!
It's very hard to call the infection forecast for the unvaxxed. If "negative efficacy among the vaxxed," then "higher levels of exposure/dosage for the unvaxxed than are natural." But that will also just lead to waves burning out faster, so it could balance out going forward.
On the other hand, if the virus is getting a little "affirmative action" in the form of lab-tailored variants and scheduled release, as remains the Occam's Razor explanation for the geography / timing of B.1 and all the VOCs, then the natural wave schedule doesn't really matter one way or the other.
Still, we've already been living with a yearly-visiting class-I-fusion-protein-bearing virus with possible neurotropy, i.e. influenza, for decades, and it wasn't like it was the apocalypse (while our natural circulating human coronaviruses bear "inactive" forms of the same proteins).
Wow I was actually thinking of doing the same! It feels like there are many people who would also appreciate this format! Also, I'll let you know that even if you have no formal experience the yearning to learn and the actual research you do means a lot more than having a degree as validation for one's role as an authority figure in science! Don't sell yourself short because a paper has not dictated your scientific worth.
As for questions I'll return to this post later and see what I can come up with! I think my brain is already burned out from proper thinking...
For legal purposes, I must acknowledge that the self-deprecation does not come with a "100% sincerity" guarantee, haha. Being asked a question I have to research is always a very productive prompt, anyway. I used to find such questions in bigger comment threads but most comment threads are just about the social/political aspect of "the pandemic" at this point in time, biology is out of season.
Autoimmune diseases are uniquely 'first world' issues (or so I have heard). Some research has been done using intestinal worms as a treatment. Something like a bored immune system that has nothing else to do so...Anyway it has only been a hundred years or so since every human being on the planet had intestinal worms. Now in western society it would be horrifying to consider the prospect but maybe we should. C-diff has become an almost incurable problem using conventional antibiotics ect but a rectal infusion of fresh stool almost always works and is gaining traction. This two year journey has facilitated a fresh look at many things in this world. I have gone from being a covid vaccine sceptic to a full on 'conspiracy theorist' rejecting almost every assumption I have incorporated into my 70 year old brain. I appreciate the part you are playing in this challenge. Do you have any ideas about the larger parasites and the role they may play in keeping our immune system healthy?
The Helminth question is an interesting one. It would seem to predict that the allergy and autoimmunity explosion should have kicked in around 1900, the same time that the hygiene-obsessed upper class started having problems with polio. Or maybe even earlier, when humans started to live near the arctic circle. As a side note I grew up partially in Bermuda where it was normal to see roundworm bumps in kids’ feet - but I never got any bumps, so it wasn’t actually universal. Still I think there’s probably something to it.
But it seems more obvious to look to measles vaccination as the culprit. Measles exposure was truly ubiquitous, and infection targets immune cells and has a years-long immune suppression effect that may help other bugs take up residence in early childhood, and the historical timing fits pretty well with when all our other problems started emerging (allowing for a lag as the first generation of vaxxed kids had to become teens and adults). Though I’m still only just beginning to look into it.
Many bacterial infections (depending on location) could be better described as “monoculture disorder” or microbiome disruption, so it makes sense that transplanting a whole intact microbiome is easier than trying to regrow one from scratch (when biofilms that survive antibiotics give the monoculture strain a head start).
What part of the world do you live in now? I live in Boise.
I am very precariously perched in Baja California. It's a relief to be somewhere where the government cannot control the economy enough to put in any real mandates, but uncomfortable being next to California where new mandates are always around the corner.
I have spent the last year looking for somewhere to move...sell my very inflated $ house and pay cash for something else in a "safer" place. Boise is a great place to live but is subject to federal mandates and being a college town very liberal mayor. The whole of Idaho is conservative but dramatic influx of people from Washington and Oregon (and California) threatens to bring the same values that have destroyed those states. Mandates on the west coast were/are egregious as you know. I have concluded that there is no escape. Grew up in Anaheim, half my adult life in Seattle, which at the time was beautiful, and now 25 years in Idaho. We all seem to live in a climate where irrational fear dominated our lives for two years. We are distracted at the moment (rational fear) by the tsunami of hysterical and like minded politicians and media rolling over Ukraine and which looks very much like the like the last one. I suspect that most governments have tasted authoritarianism and find it delicious.
Thank you. I hadn't heard from you so on a whim I checked my spam and there you were. More later.
I have this itchy spot… umm, can I send you a pic?
No need. I will incant the appropriate anti-itch spells.
SWEET
Love your avatar, hoppah! (You have read my “Letter to a Tyrant” (https://margaretannaalice.substack.com/p/letter-to-a-tyrant), right?)
Oh yes I have.
Igor Chudov recently posted something of HIV segments being in SARS-CoV-2. What's the significance of that?
Since I did not insert those segments, I can only speculate. Randomly slapping on epitopes from other proteins can only really accomplish three things: Replicate a toxic peptide, attempt to induce an anti-epitope antibody response, or leave a human signature for its own sake.
But the big things that contribute to a unique bug/host phenotype, like "acquire this tropism (tissue preference)" or "acquire this immune-evading/suppressing/modulating trait" are either spread out over multiple non-consecutive residues or are in the parts of the virus you can't swap out without breaking (like the highly conserved RdRp protein).
So back to the three things you could do. As far as 1, maybe the NTD-located inserts are contributing to microclotting, since HIV proteins are also associated with microclotting in Pretorius's research (https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0038-1676374 ) - but regular coronavirus spike might be just as toxic in this regard. As for 2, well sure, maybe Baric and Fauci built this as a chimeric "live HIV vaccine" 20 years ago, noticed it caused ARDS and became more interested in it as a "second HIV" (as in phony super-virus) and have just been working on the staging of a worldwide release since then. Who knows. As for 3, the inserts could have just been inserted to make the virus seem scarier than it is, nothing more than eyes on a butterfly's wings.
Note that the HIV virus doesn't seem like a more aggressive immune-system-attacker than measles or other common viruses, and the "causes AIDS" theory has always been very smelly.
Any thoughts on this as the root cause of autism:
https://vinuarumugham.substack.com/p/cows-milk-protein-contaminated-vaccines?s=w
My main thought whenever it comes to autoimmune sensitization is that it is always a two-part etiology, not just sensitization but failure of T Cell negative selection or perhaps gut-microbiome-mediated tolerance. It additionally seems to predict that autoimmunity, like allergies, should be reversible, again through microbiome-mediated induction of tolerance. And indeed we see this to be the case with some acute autoimmune diseases like GBS or acute tubulointerstitial nephritis. So I'm not sure autoimmunity is a natural fit for autism, even if autoimmunity (esp. with repeated sensitizations) would explain it, given that it suggests reversibility.
T cell negative selection occurs for high affinity self reactive cells. When the T cell receptor recognizes a peptide that even differs by one amino acid residue from a self-peptide, it can be positively selected. We call these low-affinity self reactive (LASR) T cells. These are necessary to fight cancer. Basically, you need T cells that are able detect peptides that are slightly different from self (cancer). These T cells however still cross react with self and can result in autoimmunity.
This is the reason we have paraneoplastic autoimmunity.
Please see details here:
https://doi.org/10.5281/zenodo.1034776
Here's a layman's version for those not familiar with biochemistry:
https://childrenshealthdefense.org/news/vaccines-containing-animal-plant-fungal-proteins-cause-autoimmune-diseases-and-cancer/
Not sure why you say allergies are reversible. Also, autoimmune diseases such as T1D are not reversible.
Right, tolerance is a two part barrier against autoimmunity which implies that neither is absolute. And yet it usually works anyway which implies that being absolute is not required in order for it to be an equally powerful mechanism as sensitization. Healthy people probably have long lived plasma cells kicking out all kinds of auto-antibodies all the time, implying prior self-sensitization, but they are protected by tolerance.
So by that same note I am skeptical that autoimmunity is the cause rather than effect of T1D, and I’ve made my own allergies go away by increasing outdoor exposure. So I think even a really plausible sensitization mechanism, such as injected homologous proteins, asks for a defense against the tolerance attack.
Have you ever looked into the childhood vaccines? The Simpsonwood transcript regarding mercury? The 'debate' letters between ICAN and HHS? Consequences of aluminum? Potential connection to autism and other autoimmune issues in children?
It's a big part of my research, but there's also a galaxy of poorly-documented history to struggle with. For example I don't consider the polio portion of Dissolving Illusions to be anything like a satisfactory examination of the millions of mysterious events in question.
That said, I regard the entire concept of vaccination as essentially pseudo-science. We know there's more to immunity than antibodies, so presuming that "preventing infection," especially by forcing the immune system to produce antibodies with alum, is intrinsically a net benefit compared to letting kids get naturally infected, is not supported by anything in the last 6 decades of research. It turned out our gut doesn't work right without bacteria. There's no reason not to assume our nervous system and immune systems don't work right without childhood chickenpox and measles invasion, respectively. Put differently, "In 1799 we didn't even know what the immune system is and yet we mastered it," doesn't pass the smell test at all.
I also wonder about the compount effect of all the different vaxes an individual gets (and other influences). I have the impression that these things are usually studied with tunnel view, isolated. And it seems to be only interesting for some reason if a product "works" according narrow to definition, but other effects and longterm, overall quality of life impact seems not to be looked at by anyone. Certainly not the developers of such products.
Paul Thomas has a good take on the toxicity of excess aluminum in the CDC infant vaccine schedule.
Stephanie Seneff "Toxic Legacy" reviews the cellular damage from glyphosate (Roundup.)
When we can't identify a cause for a particular condition, we wave our arms and declare it "multifactorial", which is likely true and a good substitute for a shrug of the shoulders and admission of ignorance.
The progress of analytical chemical tools and computing power over the past few decades makes structural determination and reactions somewhat accessible. The complexity is still a limitation to being able to determine exact causes.
For an example, have a look at the various mechanisms proposed for ivermectin's activity against Covid.
Mandates and pharma marketing have made it impossible to look at overall anything. Which is exactly what you want if propping up a psuedo-science. Everything about child vaccination after the 80s can be explained by profiteering, everything before the 70s can be explained as the last gasps of the "let's conquer this gross, useless Nature thing" attitude that led to the Scientific Method to begin with. Neither one of these admits *any* possible plus to natural infection, so there's no need to prove that preventing natural infection is a net benefit.
The “probably not” prediction in 2021 was like loading all of humanity into an experimental rocket and saying “It blew up in all the test runs, but never in a real-world use.” My prediction was ADE would be an issue coming up a year or two from now, after more antigenic drift.
Omicron (BA.1 and BA.2) is like fast-forwarding 20 years and seems to have rendered the ADE question moot. Maybe if Omicron had retained the same tissue tropism and fusion capability, it would have been a problem, but now that there’s been plenty of natural infection I don’t think we have to worry even if those qualities come back. So, score one for the hubristic vaccine hawks here.
At this point I’m inclined to think my earlier prediction was off to begin with, and a valid prediction would have been that the vaccines would have produced immediately observable ADE as with previous RSV vaccine trials. Likewise, the RSV-“ADE” mechanism is the only one that probably would have been applicable to SARS-CoV-2. This mechanism shouldn’t really be described as “ADE” but just simple allergic sensitization that leads to excessive inflammation and pneumonia. Whereas ADE is still a valid term for Dengue and maybe the failed Measles vaxxes. A good overview of all the differences is provided by the “dark side” at https://www.chop.edu/centers-programs/vaccine-education-center/vaccine-safety/antibody-dependent-enhancement-and-vaccines
There’s one last possibility which is that Covid vaccine ADE is disguised by pre-priming of some sort, given that “Covid” itself involves an RSV-ADE like inflammatory reaction. So there’s no way to tell that the vax primes ADE since the control group (some of the unvaxxed) is also primed to begin with. Could this priming be the flu vaccines? The evidence isn’t strong but it’s an interesting possibility.
Was that a GvB claim? I know that "Radagast" made a big splash by extrapolating from the innate immune suppression study to suggest that severe efficacy is a result of depressing the inflammatory response, which I think is going a bit too far with a limited study that had no control group (https://www.rintrah.nl/suppression-of-the-innate-immune-system-the-main-cause-of-the-pandemic-of-the-fully-vaccinated/). But GvB certainly excels at crafting counter-intuitive claims as well, haha.
Ha, ok that sounds like him. He seems to like to "short" T Cells.
I haven't seen anything convincing about immunodeficiency among the vaxxed, except perhaps on the super-macro level in the UK, where the virus is getting close to a "year long wave" at this point, and where long-term symptoms after infection i.e. Long Covid seem incredibly common (and may be driving 10000s out of work https://www.ons.gov.uk/employmentandlabourmarket/peopleinwork/employmentandemployeetypes/bulletins/employmentintheuk/february2022#economic-inactivity).
But why not the same in Israel, the Northeast US, etc? Or perhaps the anecdotes of skin cancers, but these seem more acute than "AIDS redux," suggesting for now that if immune suppression is involved it might be only temporary.
At the same time, there's no need to overthink things too much or look for proof of "altered innate immunity." If the transfections are causing physical harm, this alone would disrupt and depress immunity. Everything is interconnected.
I'm ambivalent on the circuitry evidence. One thing to bear in mind is that DNA/RNA already are "self-assembling" molecules, essentially strings of wobbly self-attracting bits. And lipids form barriers against aqueous solution. So just the RNA plus lipids could explain the interesting sharp lines and negative space in slides, for all we know! The big difference would be that the vials contain multiple LNPs that can bump into each other and accidentally combine, increasing the attraction potential and setting off a chain reaction, who knows. Whereas once injected into the body, they are less likely to self-collide, and quickly get other proteins stuck to them anyway. This is also probably why viruses like to insert other proteins both into the curls of their RNA and studded throughout their membranes, so they don't accidentally glue to each other!
It's very hard to call the infection forecast for the unvaxxed. If "negative efficacy among the vaxxed," then "higher levels of exposure/dosage for the unvaxxed than are natural." But that will also just lead to waves burning out faster, so it could balance out going forward.
On the other hand, if the virus is getting a little "affirmative action" in the form of lab-tailored variants and scheduled release, as remains the Occam's Razor explanation for the geography / timing of B.1 and all the VOCs, then the natural wave schedule doesn't really matter one way or the other.
Still, we've already been living with a yearly-visiting class-I-fusion-protein-bearing virus with possible neurotropy, i.e. influenza, for decades, and it wasn't like it was the apocalypse (while our natural circulating human coronaviruses bear "inactive" forms of the same proteins).