One further comment I have is: Science requires replication.
One NULL result does not overturn several previous positive findings. Perhaps the new study had sloppy methods, or like the Surgisphere paper contained made up data, or like a number of the IVM papers, was simply designed to fail.
Nice to read another post from you! I appreciate your expertise on studies. Thanks for the update. So it seems that there was temporary class switching, and people may have been vulnerable to infection for that period of time. This is a small study in one country, but I don't know if anyone else is following antibody levels with repeated vaccination in larger populations. The tolerance didn't seem to have mortal consequences (especially the more outrageous claims), but there were many reports of repeated bad colds and flus going around. (I knew many vaccinated people who were repeatedly sick more than usual, although it's impossible to be certain of cause). Beyond the fears about vaids, there are many other side effects associated with the injection that we will never get studies on. But there are evidence points showing more widespread damage from neurological damage - peripheral neuropathy, pots, cognitive decline, central nervous system dysregulation. This was pfizers largest category of injury after immediate effects of the shot (like flu symptoms, fever, sore arm, etc) at over 25,000 neurological incidences from their report of only approx 44,000 people.. Blood clotting still may be a significant issue, as well as heart damage and intestinal issues. Also chronic inflammation causing flare up her new onset of inflammatory disease like arthritis. There are billions of nanoparticles to be accounted for in people's bodies, with no studies done that I'm aware of on if/how these are broken down or leave the body. There are evidence points for all of these toxic issues I've listed, but you won't see many study tackling the long-term side effects. Yale is studying "long vaccine" as well as long covid.
It's my understanding that antibodies aren't really specific per say, in that the classes of antibodies fight all of the bugs they come in contact with.
Severe (grade III) tetanus occurred in three immunized patients who had high serum levels of anti-tetanus antibody. The disease was fatal in one patient. One patient had been hyperimmunized to produce commercial tetanus immune globulin. Two patients had received immunizations 1 year before presentation. Anti-tetanus antibody titers on admission were 25 IU/ml to 0.15 IU/ml by hemagglutination and ELISA assays; greater than 0.01 IU/ml is considered protective."
Seems like, at least for the death, IgG4 neutralizing IgG1.
Can't speak w confidence without paying for the paper, but the molecular distinction between treated "toxoid" and actual Tetanus toxin seems to be relevant here - With toxoid vaccination you're supposed to somehow generate antibodies to the original toxin despite chemical alteration of the vaccine molecule. But mRNA vaccines if nothing else ensure immune system is exposed to a pristine "demo" version of spike, by inserting proline stabilization that reduces S1 cleavage. OTOH with tetanus toxoid, all you want is antibodies to bind to the toxin so it doesn't bind to nerves, obviously the use of chemically treated molecule in vaccine leaves a gap for that not to occur. In theory - but really I don't know if any reliable data for tetanus vaccine (and booster regimen) efficacy was ever produced after first roll-out in ~50s or if we're flying blind on that one.
1. Tetanus has become much less of an issue as people moved much further away from places where bovines etc live.
2. Tetanus was much less prevalent than the fear porn suggests
3. The vaccine works so it does bind to the right place so that the toxin no longer works, so the IgG4 Abs would likely neutralize many of the IgG1 Abs potentially causing that death.
1. The particular spike being used in the vaccines keeps changing each year as they are updated. Assuming the immune system is discerning enough to notice these differences, it could also conceivably cause a plateau in tolerance, vs. seven consecutive injections of the exact same spike mRNA.
2. High antibody titers are broadly neutralizing, regardless of antibody type, as you note. If the most abundant antibodies are effectively virus-neutralizing but also not particularly immune-activating, this could conceivably create a "vaccination treadmill" where tolerance effects become more noticeable in multi-boosted people who stop getting regular shots to keep their antibody titers high.
Of course, the IgG4 scare is a farce. I have been saying so for 4 years now.
The presence is very natural.
At injection 2, the T-cells are primed and intervene very quickly, killing in-the-egg spike production, so much so that they are hardly detectable (see Ogata et al./ Yonker et al.). It's normal antibodies would be downregulated if spike proteins are no longer produced in large quantities.
But no one listens, no one studies... People are more interested. In showing off and scaring people. Thank you for this.
One further comment I have is: Science requires replication.
One NULL result does not overturn several previous positive findings. Perhaps the new study had sloppy methods, or like the Surgisphere paper contained made up data, or like a number of the IVM papers, was simply designed to fail.
Nice to read another post from you! I appreciate your expertise on studies. Thanks for the update. So it seems that there was temporary class switching, and people may have been vulnerable to infection for that period of time. This is a small study in one country, but I don't know if anyone else is following antibody levels with repeated vaccination in larger populations. The tolerance didn't seem to have mortal consequences (especially the more outrageous claims), but there were many reports of repeated bad colds and flus going around. (I knew many vaccinated people who were repeatedly sick more than usual, although it's impossible to be certain of cause). Beyond the fears about vaids, there are many other side effects associated with the injection that we will never get studies on. But there are evidence points showing more widespread damage from neurological damage - peripheral neuropathy, pots, cognitive decline, central nervous system dysregulation. This was pfizers largest category of injury after immediate effects of the shot (like flu symptoms, fever, sore arm, etc) at over 25,000 neurological incidences from their report of only approx 44,000 people.. Blood clotting still may be a significant issue, as well as heart damage and intestinal issues. Also chronic inflammation causing flare up her new onset of inflammatory disease like arthritis. There are billions of nanoparticles to be accounted for in people's bodies, with no studies done that I'm aware of on if/how these are broken down or leave the body. There are evidence points for all of these toxic issues I've listed, but you won't see many study tackling the long-term side effects. Yale is studying "long vaccine" as well as long covid.
It's my understanding that antibodies aren't really specific per say, in that the classes of antibodies fight all of the bugs they come in contact with.
Take care! 💕
https://www.neurology.org/doi/10.1212/WNL.42.4.761
"Abstract
Severe (grade III) tetanus occurred in three immunized patients who had high serum levels of anti-tetanus antibody. The disease was fatal in one patient. One patient had been hyperimmunized to produce commercial tetanus immune globulin. Two patients had received immunizations 1 year before presentation. Anti-tetanus antibody titers on admission were 25 IU/ml to 0.15 IU/ml by hemagglutination and ELISA assays; greater than 0.01 IU/ml is considered protective."
Seems like, at least for the death, IgG4 neutralizing IgG1.
Can't speak w confidence without paying for the paper, but the molecular distinction between treated "toxoid" and actual Tetanus toxin seems to be relevant here - With toxoid vaccination you're supposed to somehow generate antibodies to the original toxin despite chemical alteration of the vaccine molecule. But mRNA vaccines if nothing else ensure immune system is exposed to a pristine "demo" version of spike, by inserting proline stabilization that reduces S1 cleavage. OTOH with tetanus toxoid, all you want is antibodies to bind to the toxin so it doesn't bind to nerves, obviously the use of chemically treated molecule in vaccine leaves a gap for that not to occur. In theory - but really I don't know if any reliable data for tetanus vaccine (and booster regimen) efficacy was ever produced after first roll-out in ~50s or if we're flying blind on that one.
This paper might help. Dunno. https://www.sciencedirect.com/science/article/pii/S2211124721004010
Seems like there are three possibilities:
1. Tetanus has become much less of an issue as people moved much further away from places where bovines etc live.
2. Tetanus was much less prevalent than the fear porn suggests
3. The vaccine works so it does bind to the right place so that the toxin no longer works, so the IgG4 Abs would likely neutralize many of the IgG1 Abs potentially causing that death.
Two big-picture thoughts on this:
1. The particular spike being used in the vaccines keeps changing each year as they are updated. Assuming the immune system is discerning enough to notice these differences, it could also conceivably cause a plateau in tolerance, vs. seven consecutive injections of the exact same spike mRNA.
2. High antibody titers are broadly neutralizing, regardless of antibody type, as you note. If the most abundant antibodies are effectively virus-neutralizing but also not particularly immune-activating, this could conceivably create a "vaccination treadmill" where tolerance effects become more noticeable in multi-boosted people who stop getting regular shots to keep their antibody titers high.
haven't seen you post in forever! thanks for the proof of life :)
Of course, the IgG4 scare is a farce. I have been saying so for 4 years now.
The presence is very natural.
At injection 2, the T-cells are primed and intervene very quickly, killing in-the-egg spike production, so much so that they are hardly detectable (see Ogata et al./ Yonker et al.). It's normal antibodies would be downregulated if spike proteins are no longer produced in large quantities.
But no one listens, no one studies... People are more interested. In showing off and scaring people. Thank you for this.
Exposure to the virus can also cause this IgG4-RD to flare.
https://journal.chestnet.org/article/S0012-3692(22)01422-2/fulltext
IgG4 is not tolerance, it is desensitization.
And IgG4 can cause IgG4-RD.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10258086/