Correction to "T.N.I.I.R.S."
Litters appear to have been serial, not sequential.
A Mousey Mistake
A correction has been made to yesterday’s post. Thanks to reader John (jc) Comeau, who writes at Iotecnotic, for pointing out the controversy over whether litters were sequential or serial. I have now come to believe that it is the latter.
Original Interpretation
Mice injected, bred → 1st litter → bred → 2nd litter → bred → etc
Current Interpretation
Mice injected
bred once →
bred a second time →
etc.
Implications
My elaborate non-genetic theory for how paternal immunity, if a result of seminal cytokines, was mysteriously passed on to a second generation is no longer necessary. It is now totally naturalistic to assume that paternal immunity, if a result of seminal cytokines, is short-term and therefor fades out after the second litter. Sorry, daddy mouse, you have lost your magic touch.
It is a good thing that, in the end, I did not grant credit to a “genetic incorporation” theory. However, the reader should note that the reason for this mistake is that the text of the study is very unclear regarding the mating schedule, and it’s still at least possible that the original interpretation of the setup is the correct one (multiple generations of mice showed immune effects). Presumably there will be an update to the text at biorxiv at some point to clarify this question.
This is a therefor minor revision, and so a re-read of yesterday’s post is not required for those who already kindly invested their time in my initial review. Nonetheless, as this journal prides itself first and foremost on accurately deciphering study setups, no matter how obscure the authors’ description, I hereby sentence myself to
A Million Years of Crushing Shame
Starting today and applying to all my progeny.
Thank you for subscribing to Unglossed (which is hereby renamed Earth’s Wrongest Blog)!
Correction notice, September 6, 2022: This post was obviously incorrectly titled Correction to "T.I.I.R.S." at the time of posting (as still shown in the url). Updated sentence: 1 million years + 1 minute of Crushing Shame.
If it's any consolation, my posts have turned out to be wrong almost 100% of the time. But I leave them up so nobody can take the Earth's Wrongest Blog title away from me!
I skimmed that paper after it was shared on Greer's Ecosophia forum. My impression was in line with your correction.
I thought that LNP injection leading to lower response to future LNP-mRNA injection could be simple drug tolerance: less of a response to a second exposure to the same stimulus.
To me the only big takeaway was the innate immune reprogramming, which was documented in humans more than a year ago:
https://www.medrxiv.org/content/10.1101/2021.05.03.21256520v1
We await results of what this actually means in terms of immune health and susceptibility to common infections.